What is the NOAEL for 4-(1-Phenylethyl)benzene-1,3-diol?
4-(1-Phenylethyl)benzene-1,3-diol has 5 NOAEL studies in the database. The lowest reported value is 1.1 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
4-(1-Phenylethyl)benzene-1,3-diol
CAS 85-27-8
4-(1-Phenylethyl)benzene-1,3-diol (CAS 85-27-8) is a chemical substance. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
Cross-Vertical Regulatory Divergence
4-(1-Phenylethyl)benzene-1,3-diol is classified GHS Danger (H302, H314, H315, H318, H319, H411) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
5
SOURCE
chemical inventory jurisdictions
Regulatory lists
0
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
6 fields
Name
4-(1-Phenylethyl)benzene-1,3-diol
CAS Number
85-27-8
DTXSID
DTXSID501005319
Molecular Formula
C14H14O2
InChI Key
PQSXNIMHIHYFEE-UHFFFAOYSA-N
Monoisotopic Mass
214.09938
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
Antioxidant
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 5 of 5 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =1.1 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| G37UFG162O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| G37UFG162O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| G37UFG162O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| G37UFG162O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 5 of 5 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 4-(1-Phenylethyl)-benzene-1,3-diol | 480-070-0 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Active — Depigmenting
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3961037
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
2
Frequently Asked Questions
Is 4-(1-Phenylethyl)benzene-1,3-diol used in cosmetics?
Yes, 4-(1-Phenylethyl)benzene-1,3-diol is also indexed as a cosmetic ingredient under the name Phenylethyl Resorcinol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 4-(1-Phenylethyl)benzene-1,3-diol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 4-(1-Phenylethyl)benzene-1,3-diol have different safety status in cosmetics vs industrial chemicals?
4-(1-Phenylethyl)benzene-1,3-diol is classified GHS Danger (H302, H314, H315, H318, H319, H411) in the chemicals database but is allowed in EU cosmetics.
Is 4-(1-Phenylethyl)benzene-1,3-diol used outside industrial chemicals?
4-(1-Phenylethyl)benzene-1,3-diol also appears in cosmetics, pharmaceutical databases.