NOAEL Data REACH Registered Cosmetic Ingredient

HC Orange no. 2

Also known as: UNII-86WS98470U, 2-(4-((2-Aminoethyl)amino)-3-nitrophenoxy)ethanol, Ethanol, 2-(4-((2-aminoethyl)amino)-3-nitrophenoxy)-, HC Orange 2, Imexine FAB

CAS 85765-48-6

HC Orange no. 2 (CAS 85765-48-6) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, SCCS, ECHA REACH.

View cosmetic safety profile for HC Orange No. 2 →

Cross-Vertical Regulatory Divergence

HC Orange no. 2 is classified GHS Danger (H317, H318) in the chemicals database but is restricted in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 10 fields

Name

HC Orange no. 2

CAS Number

85765-48-6

Molecular Formula

C10H15N3O4

InChI Key

WXGKXLXGYOYZMX-UHFFFAOYSA-N

Monoisotopic Mass

241.106256

Synonyms

UNII-86WS98470U2-(4-((2-Aminoethyl)amino)-3-nitrophenoxy)ethanolEthanol, 2-(4-((2-aminoethyl)amino)-3-nitrophenoxy)-HC Orange 2Imexine FAB

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records

Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 4 records

List	Keyword	Source
Europe; Personal care; restricted	European Commission	CosIng
Canada; Personal care; Substances in PCP - Canada (4/2014)	Government of Canada	CPCat
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 23 of 23 studies

Value	Unit	Endpoint	Route	Species	Source
20	mg/kg/day	-	-	-	Regulatory source
100	mg/kg bw/day	-	-	-	Regulatory source
150	mg/kg bw	-	-	-	Regulatory source
500	mg/kg/day	-	-	-	Regulatory source
86WS98470U	UNII	FDA UNII substance identifier	-	-	openFDA substances
5	mg/kg bw/day	LOAEL	oral	rat	COSMOS DB
=0.016	mg/kg	NOAEL	oral	rat	SCCS Opinion
=20	mg/kg/day	NOAEL	-	-	SCCS Opinion
=20	mg/kg bw	NOAEL	oral	rat	SCCS Opinion
=100	mg/kg/day	NOAEL	oral	rat	SCCS Opinion
=100	mg/kg bw/day	NOAEL	-	-	SCCS Opinion
=150	mg/kg/day	NOAEL	oral	rat	SCCS Opinion
=150	mg/kg bw	NOAEL	-	-	SCCS Opinion
=500	mg/kg/day	NOAEL	-	-	SCCS Opinion
=500	mg/kg bw/day	NOAEL	-	rabbit	SCCS Opinion
=0.016	mg/kg	dermal absorption	oral	rat	Regulatory source
=20	mg/kg bw	dermal absorption	oral	rat	Regulatory source
150	mg/kg/day	dermal absorption	oral	rat	Regulatory source
20	mg/kg/day	developmental toxicity	-	rabbit	Regulatory source
100	mg/kg/day	developmental toxicity	oral	rat	Regulatory source
100	mg/kg bw/day	developmental toxicity	-	rabbit	Regulatory source
500	mg/kg bw/day	developmental toxicity	-	rabbit	Regulatory source
500	mg/kg/day	genotoxicity	-	-	Regulatory source

Showing 23 of 23 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records

Status	Name	EC Number	Link
Registered	2-(4-((2-Aminoethyl)amino)-3-nitrophenoxy)ethanol	416-410-1	ECHA overview →

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 1 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCP/1103/07	18 December 2007	The SCCP is of the opinion that, apart from the risks associated with the use of a strong sensitiser, the use of HC Orange n° 2, at a maximum concentration of 1.0% on the head, does not pose any other risk to the health of the consumer.	1.0% on the head	Strong skin sensitiser (per EC3-value); secondary amine prone to nitrosation, should not be used with nitrosating substances, nitrosamine content should be < 50 ppb.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

Frequently Asked Questions

What is the NOAEL for HC Orange no. 2?

HC Orange no. 2 has 23 NOAEL studies in the database. The lowest reported value is 0.016 mg/kg via oral in rat. Source: SCCS Opinion.

What regulatory lists include HC Orange no. 2?

HC Orange no. 2 appears on 3 regulatory/inventory lists including Europe; Personal care; restricted, Canada; Personal care; Substances in PCP - Canada (4/2014), children; Europe; Personal care. Source: EPA CPDat.

Is HC Orange no. 2 used in cosmetics?

Yes, HC Orange no. 2 is also indexed as a cosmetic ingredient under the name HC Orange No. 2. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for HC Orange no. 2 come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does HC Orange no. 2 have different safety status in cosmetics vs industrial chemicals?

HC Orange no. 2 is classified GHS Danger (H317, H318) in the chemicals database but is restricted in EU cosmetics.

Is HC Orange no. 2 used outside industrial chemicals?

HC Orange no. 2 also appears in cosmetics databases.