What is the NOAEL for C.I. Acid Blue 74?
C.I. Acid Blue 74 has 29 NOAEL studies in the database. The lowest reported value is 5 mg/kg via oral in Human. Source: ToxValDB_WHO_JECFA_ADI.
NOAEL Data
REACH Registered
Cosmetic Ingredient
C.I. Acid Blue 74
Also known as: Indigo carmine, FD & C Blue No. 2, Disodium 3-oxo-2-(3-oxo-5-sulfonato-1,3-dihydro-2H-indol-2-ylidene)-2,3-dihydro-1H-indole-5-sulfonate, 12070 Blue, 1311 Blue (+15 more)
CAS 860-22-0
C.I. Acid Blue 74 (CAS 860-22-0) is a chemical substance. Key regulatory status: REACH registered, 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
29
SOURCE
chemical inventory jurisdictions
Regulatory lists
8
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
C.I. Acid Blue 74
CAS Number
860-22-0
DTXSID
DTXSID1020190
Molecular Formula
C16H10N2O8S2.2Na
InChI Key
KHLVKKOJDHCJMG-UHFFFAOYSA-L
Monoisotopic Mass
467.967396
Synonyms
Indigo carmineFD & C Blue No. 2Disodium 3-oxo-2-(3-oxo-5-sulfonato-1,3-dihydro-2H-indol-2-ylidene)-2,3-dihydro-1H-indole-5-sulfonate12070 Blue1311 BlueAniline Carmine PowderBasovit Blue 665EBlue 2Blue No. 2C.I. 73015C.I. 75781Carmine Blue
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
8 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
8 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| inert_ingredient; Pesticides | EPA | CPCat |
| general_foods | FDA | United States Food and Drug Administration (FDA) |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| Medical/dental | FDA | United States Food and Drug Administration (FDA) |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 29 of 29 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| <=5 | mg/kg | ADI | oral | Human | ToxValDB_WHO_JECFA_ADI |
| =5 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =5 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| D3741U8K7L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| D3741U8K7L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| D3741U8K7L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| D3741U8K7L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| L06K8R7DQK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| L06K8R7DQK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| L06K8R7DQK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| L06K8R7DQK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 250 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =250 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 500 | mg/kg bw/day | NOAEL | oral | dog | COSMOS_DB |
| =500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =500 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =500 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 1000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =1282 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 1350 | mg/kg bw/day | NOAEL | oral | swine | COSMOS_DB |
| =1592 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 2400 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 2500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 7500 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| =8259 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =9456 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =2000 | mg/kg bw/day | NOEL | oral | Mouse | ToxValDB_ECOTOX |
Showing 29 of 29 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Disodium 5,5'-(2-(1,3-dihydro-3-oxo-2H-indazol-2-ylidene)-1,2-dihydro-3H-indol-3-one)disulphonate | 212-728-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Colorants
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
INDIGOTINDISULFONATE SODIUM
ChEMBL Phase
4
Adverse Events
0
Bioactivity
5
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E132 — ADI: 5 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include C.I. Acid Blue 74?
C.I. Acid Blue 74 appears on 7 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, inert_ingredient; Pesticides, general_foods, and 4 more. Source: EPA CPDat.
Is C.I. Acid Blue 74 used in cosmetics?
Yes, C.I. Acid Blue 74 is also indexed as a cosmetic ingredient under the name CI 73015. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for C.I. Acid Blue 74 come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is C.I. Acid Blue 74 used outside industrial chemicals?
C.I. Acid Blue 74 also appears in cosmetics, pharmaceutical, food safety, cannabis databases.