What is the NOAEL for L-Tartaric acid?
L-Tartaric acid has 40 NOAEL studies in the database. The lowest reported value is -2 % via Dermal. Source: NTP ICE skin sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
L-Tartaric acid
Also known as: L-(+)-Tartaric acid, d-alpha,beta-Dihydroxysuccinic acid, EINECS 201-766-0, Kyselina 2,3-dihydroxybutandiova, Kyselina vinna (+15 more)
CAS 87-69-4
L-Tartaric acid (CAS 87-69-4) is a chemical substance. Key regulatory status: REACH registered, 16 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
L-Tartaric acid is classified GHS Danger (H302, H315, H317, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
40
SOURCE
Chemical inventory jurisdictions
Regulatory lists
16
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
L-Tartaric acid
CAS Number
87-69-4
Molecular Formula
C4H6O6
InChI Key
FEWJPZIEWOKRBE-JCYAYHJZSA-N
Monoisotopic Mass
150.016438
Synonyms
L-(+)-Tartaric acidd-alpha,beta-Dihydroxysuccinic acidEINECS 201-766-0Kyselina 2,3-dihydroxybutandiovaKyselina vinnaUNII-W4888I119H(+)-Weinsaeure(+)-tartarate(1R,2R)-1,2-Dihydroxyethane-1,2-dicarboxylic acid(2R,3R)-2,3-Dihydroxybernsteinsaeure(2R,3R)-2,3-dihydroxybutanedioate(2R,3R)-2,3-tartaric acid
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
37 records
pH regulating agentDeodorizerFragranceAnti-streaking agentProcessing aids not otherwise specifiedHumectantFlavouring and nutrientDrierLeavening agentStabilizing agentAnti-caking agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
16 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| IFRA Transparency | IFRA | IFRA |
| consumer_product | P&G | Proctor & Gamble |
| pharmaceutical | US International Trade Commission | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| active_ingredient; Australia | Australian Pesticides and Veterinary Medicines Authority | CPCat |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bath salts | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - general moisturizing - hand/body lotion | Danish Environmental Protection Agency | Danish EPA |
| animal_products | USDA | United States Department of Agriculture (USDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| consumer_product | P&G | Proctor & Gamble |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 40 of 40 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| <=30 | mg/kg | ADI | oral | Human | WHO/JECFA |
| <=30 | mg/kg bw/day | ADI (group) | - | Consumers | EFSA |
| =240 | mg/kg bw/day | ADI (group) | - | Consumers | EFSA |
| >1051 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 416.7 | ug/mL | CV75 | Dermal | - | NTP ICE skin sensitization |
| 3.8 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| 6.6 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| -2 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 1.2 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 2.3 | % | Depletion Lys + Cys | Dermal | - | NTP ICE skin sensitization |
| 2.5 | % | Depletion Lys + Cys | Dermal | - | NTP ICE skin sensitization |
| 3 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| >2000 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| W4888I119H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 70.2 | uM | IC50 | Dermal | - | NTP ICE skin sensitization |
| >2400 | uM | IC50 | Dermal | - | NTP ICE skin sensitization |
| 1.2 | ratio | Imax | Dermal | - | NTP ICE skin sensitization |
| 1.277 | ratio | Imax | Dermal | - | NTP ICE skin sensitization |
| 15.3 | ratio | Imax | Dermal | - | NTP ICE skin sensitization |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| <5000 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| ~181 | mg/kg bw/day | LEL | oral | Rat | ECHA |
| =310 | mg/kg bw/day | LEL | oral | Rat | ECHA |
| =2800 | mg/kg bw/day | LEL | oral | Rat | ECHA |
| ~3606 | mg/kg bw/day | LEL | oral | Mouse | ECHA |
| ~5000 | mg/kg bw/day | LEL | oral | Rabbit | ECHA |
| ~1.000e+4 | mg/kg bw/day | LEL | oral | Cat | ECHA |
| 0 | unitless | Model Score | - | - | NTP ICE endocrine |
| 181 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 215 | mg/kg bw/day | NOAEL | oral | rabbit | COSMOS DB |
| 225 | mg/kg bw/day | NOAEL | oral | hamster | COSMOS DB |
| ~225 | mg/kg bw/day | NOAEL | oral | Hamster | ECHA |
| 274 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS DB |
| ~274 | mg/kg bw/day | NOAEL | oral | Mouse | ECHA |
| 990 | mg/kg bw/day | NOAEL | oral | dog | COSMOS DB |
| 1200 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| ~3000 | mg/kg bw/day | NOAEL | oral | Mouse | ECHA |
| =3100 | mg/kg bw/day | NOAEL | oral | Rat | EFSA |
| =3100 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA |
| =96 | mg/L | NOEL | oral | Mouse | ToxValDB ECOTOX |
Showing 40 of 40 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | (+)-tartaric acid | 201-766-0 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
pH-adjuster
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
TARTARIC ACID
ChEMBL Phase
4
Adverse Events
0
Bioactivity
2
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
E334 — ADI: 30 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include L-Tartaric acid?
L-Tartaric acid appears on 14 regulatory/inventory lists including active_ingredient; Europe; Pesticides, IFRA Transparency, consumer_product, and 11 more. Source: EPA CPDat.
Is L-Tartaric acid used in cosmetics?
Yes, L-Tartaric acid is also indexed as a cosmetic ingredient under the name Tartaric Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for L-Tartaric acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does L-Tartaric acid have different safety status in cosmetics vs industrial chemicals?
L-Tartaric acid is classified GHS Danger (H302, H315, H317, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.
Is L-Tartaric acid used outside industrial chemicals?
L-Tartaric acid also appears in cosmetics, pharmaceutical, food safety, cannabis databases.