NOAEL Data REACH Registered Cosmetic Ingredient

Xylitol

Also known as: BRN 1720523, EINECS 201-788-0, UNII-VCQ006KQ1E, (2R,4S)-pentane-1,2,3,4,5-pentol, Eutrit (+6 more)

CAS 87-99-0

Xylitol (CAS 87-99-0) is a chemical substance. Key regulatory status: REACH registered, 11 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Xylitol →

SOURCE noael studies public
NOAEL studies
28
SOURCE chemical inventory jurisdictions
Regulatory lists
11
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 17 fields
Name
Xylitol
CAS Number
87-99-0
DTXSID
DTXSID7042514
Molecular Formula
C5H12O5
InChI Key
HEBKCHPVOIAQTA-SCDXWVJYSA-N
Monoisotopic Mass
152.068473
Synonyms
BRN 1720523EINECS 201-788-0UNII-VCQ006KQ1E(2R,4S)-pentane-1,2,3,4,5-pentolEutritKlinitKylitL-xylitolXylitXylite (sugar)xylite

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 14 records
HumectantSoftener and conditionerFlavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 11 records
ListKeywordSource
Canada; Personal care; Substances in PCP - Canada (4/2014)Government of CanadaCPCat
Canada; consumer_product; Substances in Products - Canada (4/2014)Government of CanadaCPCat
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal care - dental care - toothpasteDanish Environmental Protection AgencyDanish EPA
Europe; Personal careDanish Environmental Protection AgencyDanish EPA
Europe; Personal careDanish Environmental Protection AgencyDanish EPA
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)FDAUnited States Food and Drug Administration (FDA)
Canada; pharmaceuticalDrugBankDrugBank
Canada; pharmaceuticalDrugBankDrugBank
Europe; Personal care - oral and dental care - teeth whitenerDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - oral and dental care - teeth whitenerDanish Environmental Protection AgencyDanish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 28 of 28 studies
ValueUnitEndpointRouteSpeciesSource
VCQ006KQ1EUNIIFDA UNII substance identifier--openFDA substances
VCQ006KQ1EUNIIFDA UNII substance identifier--openFDA substances
VCQ006KQ1EUNIIFDA UNII substance identifier--openFDA substances
VCQ006KQ1EUNIIFDA UNII substance identifier--openFDA substances
>4000mg/kg bwLD50oralRatNTP_ICE_acute_oral
=14100mg/kg bwLD50oralRatNTP_ICE_acute_oral
=16500mg/kg bwLD50oralRatNTP_ICE_acute_oral
=17300mg/kg bwLD50oralRatNTP_ICE_acute_oral
680mg/kg bw/dayNOAELoralratCOSMOS_DB
1000mg/kg bw/dayNOAELoralmonkeyCOSMOS_DB
1250mg/kg bw/dayNOAELoraldogCOSMOS_DB
2200mg/kg bw/dayNOAELoralmouseCOSMOS_DB
2500mg/kg bw/dayNOAELoralratCOSMOS_DB
5000mg/kg bw/dayNOAELoralratCOSMOS_DB
6770mg/kg bw/dayNOAELoralrabbitCOSMOS_DB
=6770mg/kg bw/dayNOAELoralRabbitToxValDB_ECHA_IUCLID
7500mg/kg bw/dayNOAELoralmouseCOSMOS_DB
8500mg/kg bw/dayNOAELoralmouseCOSMOS_DB
9167mg/kg bw/dayNOAELoralratCOSMOS_DB
9847mg/kg bw/dayNOAELoralratCOSMOS_DB
10000mg/kg bw/dayNOAELoralratCOSMOS_DB
12100mg/kg bw/dayNOAELoralratCOSMOS_DB
15000mg/kg bw/dayNOAELoralmouseCOSMOS_DB
20100mg/kg bw/dayNOAELoralmouseCOSMOS_DB
25200mg/kg bw/dayNOAELoralmouseCOSMOS_DB
26667mg/kg bw/dayNOAELoralmouseCOSMOS_DB
27188mg/kg bw/dayNOAELoralmouseCOSMOS_DB
50000mg/kg bw/dayNOAELoralmouseCOSMOS_DB

Showing 28 of 28 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
RegisteredXylitol201-788-0ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
humectant
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL XYLITOL
ChEMBL Phase
3
Adverse Events
27
Bioactivity
2
View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

E967 — ADI: NOT SPECIFIED mg/kg bw

View full food safety profile →

Frequently Asked Questions

What is the NOAEL for Xylitol?

Xylitol has 28 NOAEL studies in the database. The lowest reported value is VCQ006KQ1E UNII. Source: openFDA substances.

What regulatory lists include Xylitol?

Xylitol appears on 8 regulatory/inventory lists including Canada; Personal care; Substances in PCP - Canada (4/2014), Canada; consumer_product; Substances in Products - Canada (4/2014), children; Europe; Personal care, and 5 more. Source: EPA CPDat.

Is Xylitol used in cosmetics?

Yes, Xylitol is also indexed as a cosmetic ingredient under the name Xylitol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Xylitol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.

Is Xylitol used outside industrial chemicals?

Xylitol also appears in cosmetics, pharmaceutical, food safety databases.