What is the NOAEL for Xylitol?
Xylitol has 25 NOAEL studies in the database. The lowest reported value is VCQ006KQ1E UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Xylitol
Also known as: BRN 1720523, EINECS 201-788-0, UNII-VCQ006KQ1E, (2R,4S)-pentane-1,2,3,4,5-pentol, Eutrit (+6 more)
CAS 87-99-0
Xylitol (CAS 87-99-0) is a chemical substance. Key regulatory status: REACH registered, 11 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
NOAEL studies
NOAEL studies
25
SOURCE
Chemical inventory jurisdictions
Regulatory lists
11
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
16 fields
Name
Xylitol
CAS Number
87-99-0
Molecular Formula
C5H12O5
InChI Key
HEBKCHPVOIAQTA-SCDXWVJYSA-N
Monoisotopic Mass
152.068473
Synonyms
BRN 1720523EINECS 201-788-0UNII-VCQ006KQ1E(2R,4S)-pentane-1,2,3,4,5-pentolEutritKlinitKylitL-xylitolXylitXylite (sugar)xylite
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
14 records
HumectantSoftener and conditionerFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
11 records
| List | Keyword | Source |
|---|---|---|
| Canada; Personal care; Substances in PCP - Canada (4/2014) | Government of Canada | CPCat |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - dental care - toothpaste | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Europe; Personal care - oral and dental care - teeth whitener | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - oral and dental care - teeth whitener | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 25 of 25 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| VCQ006KQ1E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >4000 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =1.410e+4 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =1.650e+4 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =1.730e+4 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| 680 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 1000 | mg/kg bw/day | NOAEL | oral | monkey | COSMOS DB |
| 1250 | mg/kg bw/day | NOAEL | oral | dog | COSMOS DB |
| 2200 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS DB |
| 2500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 5000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 6770 | mg/kg bw/day | NOAEL | oral | rabbit | COSMOS DB |
| =6770 | mg/kg bw/day | NOAEL | oral | Rabbit | ECHA |
| 7500 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS DB |
| 8500 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS DB |
| 9167 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 9847 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 1.000e+4 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 1.210e+4 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 1.500e+4 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS DB |
| 2.010e+4 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS DB |
| 2.520e+4 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS DB |
| 2.667e+4 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS DB |
| 2.719e+4 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS DB |
| 5.000e+4 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS DB |
Showing 25 of 25 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Xylitol | 201-788-0 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
humectant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
XYLITOL
ChEMBL Phase
3
Adverse Events
27
Bioactivity
2
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
E967 — ADI: NOT SPECIFIED mg/kg bw
View full food safety profile →Frequently Asked Questions
What regulatory lists include Xylitol?
Xylitol appears on 8 regulatory/inventory lists including Canada; Personal care; Substances in PCP - Canada (4/2014), Canada; consumer_product; Substances in Products - Canada (4/2014), children; Europe; Personal care, and 5 more. Source: EPA CPDat.
Is Xylitol used in cosmetics?
Yes, Xylitol is also indexed as a cosmetic ingredient under the name Xylitol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Xylitol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Is Xylitol used outside industrial chemicals?
Xylitol also appears in cosmetics, pharmaceutical, food safety databases.