NOAEL Data REACH Registered Cosmetic Ingredient

1-Phenyl-3-methyl-5-pyrazolone

Also known as: BRN 0609575, CI Developer 1, EINECS 201-891-0, NCI-C03952, 1-Phenyl-3-methyl-5-oxo-2-pyrazoline (+8 more)

CAS 89-25-8

1-Phenyl-3-methyl-5-pyrazolone (CAS 89-25-8) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for Phenyl Methyl Pyrazolone →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 19 fields

Name

1-Phenyl-3-methyl-5-pyrazolone

CAS Number

89-25-8

DTXSID

DTXSID9021130

Molecular Formula

C10H10N2O

InChI Key

QELUYTUMUWHWMC-UHFFFAOYSA-N

Monoisotopic Mass

174.079313

Synonyms

BRN 0609575CI Developer 1EINECS 201-891-0NCI-C039521-Phenyl-3-methyl-5-oxo-2-pyrazoline1-Phenyl-3-methylpyrazolone1-Phenyl-3-methylpyrazolone-55-Pyrazolone, 3-methyl-1-phenyl-1-Fenyl-3-methyl-2-pyrazolin-5-onUNII-S798V6YJRPC.I. developer 1phenyl methyl pyrazolone

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 3 records

Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 4 records

List	Keyword	Source
Europe; Personal care; restricted	European Commission	CosIng
Canada; pharmaceutical	DrugBank	DrugBank
Canada; pharmaceutical	DrugBank	DrugBank
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 55 studies

Value	Unit	Endpoint	Route	Species	Source
20	mg/kg/day	-	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
417	ug/mL	CV75	Dermal	-	NTP_ICE_skin_sensitization
2	uL/min/10^6 cells	Clint	-	Human	NTP_ICE_adme_parameters
4000	uM	EC1.5	Dermal	-	NTP_ICE_skin_sensitization
8.3	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
8.3	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
8.3	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
8.3	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
8.5	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
S798V6YJRP	UNII	FDA UNII substance identifier	-	-	openFDA substances
S798V6YJRP	UNII	FDA UNII substance identifier	-	-	openFDA substances
S798V6YJRP	UNII	FDA UNII substance identifier	-	-	openFDA substances
S798V6YJRP	UNII	FDA UNII substance identifier	-	-	openFDA substances
0.89	fraction	Fu	-	Human	NTP_ICE_adme_parameters
1.2	ratio	Imax	Dermal	-	NTP_ICE_skin_sensitization
=1915	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=0.003	mg/kg bw	NOAEL	dermal	rat	SCCS_vision_codex
=0.003	mg/kg bw	NOAEL	dermal	rat	SCCS_vision_codex
=0.003	mg/kg bw	NOAEL	dermal	rat	SCCS_vision_codex
=0.003	mg/kg bw	NOAEL	dermal	rat	SCCS_vision_codex
=20	mg/kg/day	NOAEL	-	-	SCCS_vision_codex
=20	mg/kg bw	NOAEL	-	rat	SCCS_vision_codex
=20	mg/kg/day	NOAEL	-	-	SCCS_vision_codex
=20	mg/kg bw	NOAEL	-	rat	SCCS_vision_codex
=20	mg/kg/day	NOAEL	-	-	SCCS_vision_codex
=20	mg/kg bw	NOAEL	-	rat	SCCS_vision_codex
=20	mg/kg/day	NOAEL	-	-	SCCS_vision_codex
=20	mg/kg bw	NOAEL	-	rat	SCCS_vision_codex
=100	mg/kg bw	NOAEL	oral	rat	SCCS_vision_codex
=100	mg/kg/day	NOAEL	oral	rat	SCCS_vision_codex
=100	mg/kg bw	NOAEL	oral	rat	SCCS_vision_codex
=100	mg/kg/day	NOAEL	oral	rat	SCCS_vision_codex
=100	mg/kg bw	NOAEL	oral	rat	SCCS_vision_codex
=100	mg/kg/day	NOAEL	oral	rat	SCCS_vision_codex
=100	mg/kg bw	NOAEL	oral	rat	SCCS_vision_codex
=100	mg/kg/day	NOAEL	oral	rat	SCCS_vision_codex
=200	mg/kg/day	NOAEL	-	human	SCCS_vision_codex
=200	mg/kg/day	NOAEL	-	human	SCCS_vision_codex
=200	mg/kg/day	NOAEL	-	human	SCCS_vision_codex
=200	mg/kg/day	NOAEL	-	human	SCCS_vision_codex
=1000	mg/kg/day	NOAEL	dermal	rat	SCCS_vision_codex
=1000	mg/kg/day	NOAEL	dermal	rat	SCCS_vision_codex
=1000	mg/kg/day	NOAEL	dermal	rat	SCCS_vision_codex
=1000	mg/kg/day	NOAEL	dermal	rat	SCCS_vision_codex
5000	ppm	Top dose	-	Rat	NTP_ICE_cancer
15000	ppm	Top dose	-	Mouse	NTP_ICE_cancer
0.003	mg/kg bw	dermal absorption	dermal	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
=100	mg/kg bw	dermal absorption	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
=100	mg/kg bw	dermal absorption	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
100	mg/kg/day	developmental toxicity	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies

Showing 50 of 55 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	3-methyl-1-phenyl-5-pyrazolone	201-891-0	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 1 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCP/1003/06	19 December 2006	safe	0.25%	sensitisation not excluded

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

0.25%

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL EDARAVONE

ChEMBL Phase

Adverse Events

155

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for 1-Phenyl-3-methyl-5-pyrazolone?

1-Phenyl-3-methyl-5-pyrazolone has 55 NOAEL studies in the database. The lowest reported value is 0.003 mg/kg bw via dermal in rat. Source: SCCS_vision_codex.

What regulatory lists include 1-Phenyl-3-methyl-5-pyrazolone?

1-Phenyl-3-methyl-5-pyrazolone appears on 3 regulatory/inventory lists including Europe; Personal care; restricted, Canada; pharmaceutical, Europe; Personal care - hair coloring. Source: EPA CPDat.

Is 1-Phenyl-3-methyl-5-pyrazolone used in cosmetics?

Yes, 1-Phenyl-3-methyl-5-pyrazolone is also indexed as a cosmetic ingredient under the name Phenyl Methyl Pyrazolone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 1-Phenyl-3-methyl-5-pyrazolone come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Is 1-Phenyl-3-methyl-5-pyrazolone used outside industrial chemicals?

1-Phenyl-3-methyl-5-pyrazolone also appears in cosmetics, pharmaceutical databases.