What is the NOAEL for Dl-Menthone?
Dl-Menthone has 10 NOAEL studies in the database. The lowest reported value is 6.99 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Dl-Menthone
Also known as: Cyclohexanone, 5-methyl-2-(1-methylethyl)-, (2R,5S)-rel-, (2R,5S)-5-Methyl-2-(propan-2-yl)cyclohexanone, Cyclohexan-1-one, 2-isopropyl-5-methyl-, racemic, EINECS 201-941-1, EINECS 214-049-2 (+5 more)
CAS 89-80-5
Dl-Menthone (CAS 89-80-5) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
10
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
16 fields
Name
Dl-Menthone
CAS Number
89-80-5
DTXSID
DTXSID2044478
Molecular Formula
C10H18O
InChI Key
NFLGAXVYCFJBMK-DTWKUNHWSA-N
Monoisotopic Mass
154.135765
Synonyms
Cyclohexanone, 5-methyl-2-(1-methylethyl)-, (2R,5S)-rel-(2R,5S)-5-Methyl-2-(propan-2-yl)cyclohexanoneCyclohexan-1-one, 2-isopropyl-5-methyl-, racemicEINECS 201-941-1EINECS 214-049-2FEMA No. 2667p-Menthan-3-one racemicMenthone racemic5-Methyl-2-(1-methylethyl)cyclohexanone, trans-UNII-9NH5J4V8FN
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
46 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
| Europe | European Commission | Fl@vis |
| IFRA Transparency | IFRA | IFRA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =6.99 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =39.5 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 9NH5J4V8FN | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9NH5J4V8FN | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9NH5J4V8FN | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9NH5J4V8FN | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 5184 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =500 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 10 of 10 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | trans-menthone | 201-941-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Dl-Menthone?
Dl-Menthone appears on 4 regulatory/inventory lists including IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), consumer_product, and 1 more. Source: EPA CPDat.
Is Dl-Menthone used in cosmetics?
Yes, Dl-Menthone is also indexed as a cosmetic ingredient under the name MENTHONE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Dl-Menthone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Dl-Menthone used outside industrial chemicals?
Dl-Menthone also appears in cosmetics, food safety, cannabis databases.