Danger GHS07GHS05 NOAEL Data REACH Registered Cosmetic Ingredient

1-Naphthol

Also known as: 1-naphthalenol, NAPHTHOL, CI Oxidation Base 33, EINECS 201-969-4, UNII-2A71EAQ389 (+6 more)

CAS 90-15-3

1-Naphthol (CAS 90-15-3) is a chemical substance with GHS signal word Danger; key hazard signal: H312; H302; H335; H315; H318. Key regulatory status: REACH registered, 58 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for 1-Naphthol →

Cross-Vertical Regulatory Divergence

1-Naphthol is classified GHS Danger (H312, H302, H335, H315, H318) in the chemicals database but is restricted in EU cosmetics at max 2.0%.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status/eu_max; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 16 fields

Name

1-Naphthol

CAS Number

90-15-3

Molecular Formula

C10H8O

InChI Key

KJCVRFUGPWSIIH-UHFFFAOYSA-N

Monoisotopic Mass

144.057515

Synonyms

1-naphthalenolNAPHTHOLCI Oxidation Base 33EINECS 201-969-4UNII-2A71EAQ389Naphthol-1Naphthyl-1-olTertral ERNalpha-Naphtholalpha-Naphthyl alcoholalpha-hydroxynaphthalene

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Acute Tox. 4 ; Acute Tox. 4 ; STOT SE 3; Skin Irrit. 2; Eye Dam. 1	H312; H302; H335; H315; H318	GHS07; GHS05	Danger

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 54 records

DyeIntermediateDegradant/impurity

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 58 records

List	Keyword	Source
Europe; Personal care; restricted	European Commission	CosIng
Europe; Personal care; restricted	European Commission	CosIng
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - hair coloring - hair color - professional	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - hair coloring - hair color - professional	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
agricultural; animal_products; detected; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; animal_products; detected; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; animal_products; detected; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; animal_products; detected; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 61 studies

Value	Unit	Endpoint	Route	Species	Source
20	mg/kg	-	oral	rat	Regulatory source
20	mg/kg bw	-	dermal	-	Regulatory source
130	mg/kg bw/day	-	-	rat	Regulatory source
130	mg/kg bw	-	-	rat	Regulatory source
41.63	uM	AC50	-	-	NTP ICE endocrine
26.3	uM	ACC	-	-	NTP ICE endocrine
12.7	ug/mL	CD54, EC200	Dermal	-	NTP ICE skin sensitization
1.4	ug/mL	CD86, EC150	Dermal	-	NTP ICE skin sensitization
18.3	ug/mL	CD86, EC150	Dermal	-	NTP ICE skin sensitization
57.2	ug/mL	CV75	Dermal	-	NTP ICE skin sensitization
0	uL/min/10^6 cells	Clint	-	Human	NTP ICE adme parameters
=4.58	mg/m3	DNEL systemic	inhalation	Human	ToxValDB GESTIS DNEL
21.8	%	Depletion Cys	Dermal	-	NTP ICE skin sensitization
68.2	%	Depletion Cys	Dermal	-	NTP ICE skin sensitization
12.4	%	Depletion Lys	Dermal	-	NTP ICE skin sensitization
17.4	%	Depletion Lys	Dermal	-	NTP ICE skin sensitization
20	%	Depletion Lys + Cys	Dermal	-	NTP ICE skin sensitization
40.3	%	Depletion Lys + Cys	Dermal	-	NTP ICE skin sensitization
129.6	uM	EC1.5	Dermal	-	NTP ICE skin sensitization
1.3	%	EC3	Dermal	Mouse	NTP ICE skin sensitization
2A71EAQ389	UNII	FDA UNII substance identifier	-	-	openFDA substances
0.0682	fraction	Fu	-	Human	NTP ICE adme parameters
541	uM	IC50	Dermal	-	NTP ICE skin sensitization
1.78	ratio	Imax	Dermal	-	NTP ICE skin sensitization
1.89	ratio	Imax	Dermal	-	NTP ICE skin sensitization
>0.42	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
=1870	mg/kg bw	LD50	oral	Rat (Male)	NTP ICE acute oral
=2380	mg/kg bw	LD50	oral	Rat (Male)	NTP ICE acute oral
=2590	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
=1000	mg/kg bw/day	LEL	oral	Rat	ECHA
100	mg/kg bw/day	LOAEL	oral	rat	COSMOS DB
~400	mg/kg bw/day	LOAEL	oral	Rat	ECHA
~600	mg/kg bw/day	LOAEL	oral	Rat	ECHA
=1	mg/kg bw/day	LOEL	oral	Rat	ToxValDB ECOTOX
0	unitless	Model Score	-	-	NTP ICE endocrine
0.0232	unitless	Model Score	-	-	NTP ICE endocrine
20	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
=20	mg/kg bw	NOAEL	dermal	-	SCCS Opinion
=20	mg/kg bw/day	NOAEL	-	human	SCCS Opinion
=20	mg/kg bw/day	NOAEL	-	rat	SCCNFP Opinion
=20	mg/kg	NOAEL	oral	rat	SCCNFP Opinion
=65	mg/kg bw/day	NOAEL	-	rat	SCCS Opinion
~100	mg/kg bw/day	NOAEL	oral	Mouse	ECHA
=100	mg/kg bw/day	NOAEL	oral	rat	SCCS Opinion
=100	mg/kg bw/day	NOAEL	-	rat	SCCNFP Opinion
~120	mg/kg bw/day	NOAEL	oral	Rat	ECHA
~130	mg/kg bw/day	NOAEL	oral	Rat	ECHA
=130	mg/kg bw/day	NOAEL	-	rat	SCCS Opinion
=130	mg/kg bw	NOAEL	-	rat	SCCS Opinion
>200	mg/kg bw/day	NOAEL	oral	Mouse	ECHA

Showing 50 of 61 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records

Status	Name	EC Number	Link
Registered	1-naphthol	201-969-4	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 1 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCP/1123/07	2008-04-15	The SCCP is of the opinion that, apart from the risks associated with the use of a strong sensitiser, the use of 1-naphthol itself in oxidative hair dye formulations at a maximum concentration of 2.0% on the head, does not pose any other risk to the health of the consumer.	2.0% on the head	Strong sensitiser. 1-Naphthol itself has no mutagenic potential, but genotoxicity/mutagenicity studies in finished hair dye formulations should be undertaken per SCCNFP/SCCP opinions and Notes of Guidance.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

2.0%

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed 1-NAPHTHOL

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for 1-Naphthol?

1-Naphthol (CAS 90-15-3) is classified under EU CLP Annex VI as Acute Tox. 4 *; Acute Tox. 4 *; STOT SE 3; Skin Irrit. 2; Eye Dam. 1 with signal word Danger. Hazard statements: H312; H302; H335; H315; H318. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 1-Naphthol?

1-Naphthol has 61 NOAEL studies in the database. The lowest reported value is 0 uL/min/10^6 cells in Human. Source: NTP ICE adme parameters.

What regulatory lists include 1-Naphthol?

1-Naphthol appears on 10 regulatory/inventory lists including Europe; Personal care; restricted, Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe, Europe; Personal care - hair coloring, and 7 more. Source: EPA CPDat.

Is 1-Naphthol used in cosmetics?

Yes, 1-Naphthol is also indexed as a cosmetic ingredient under the name 1-Naphthol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 1-Naphthol come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does 1-Naphthol have different safety status in cosmetics vs industrial chemicals?

1-Naphthol is classified GHS Danger (H312, H302, H335, H315, H318) in the chemicals database but is restricted in EU cosmetics at max 2.0%.

Is 1-Naphthol used outside industrial chemicals?

1-Naphthol also appears in cosmetics, pharmaceutical databases.