What is the NOAEL for Butoxypolypropylene glycol?
Butoxypolypropylene glycol has 39 NOAEL studies in the database. The lowest reported value is 2.9 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Butoxypolypropylene glycol
Also known as: Poly[oxy(methyl-1,2-ethanediyl)], .alpha.-butyl-.omega.-hydroxy-, Poly(oxy(methyl-1,2-ethanediyl)),alpha-butyl-omega-hydroxy-, Polyoxypropylene monobutyl ether, Ambiflo L-317, Butoxy polypropylene glycol (+14 more)
CAS 9003-13-8
Butoxypolypropylene glycol (CAS 9003-13-8) is a chemical substance. Key regulatory status: REACH registered, 35 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
NOAEL studies
NOAEL studies
39
SOURCE
Chemical inventory jurisdictions
Regulatory lists
35
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
23 fields
Name
Butoxypolypropylene glycol
CAS Number
9003-13-8
Molecular Formula
C7H16O2
Monoisotopic Mass
132.11503
Synonyms
Poly[oxy(methyl-1,2-ethanediyl)], .alpha.-butyl-.omega.-hydroxy-Poly(oxy(methyl-1,2-ethanediyl)),alpha-butyl-omega-hydroxy-Polyoxypropylene monobutyl etherAmbiflo L-317Butoxy polypropylene glycolButoxypolypropylene glycol 400Butoxypolypropylene glycol 800Butoxypropanediol polymerCaswell No. 122Crag fly repellentEPA Pesticide Chemical Code 011901Exp. miticide No. 7
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
SolventSoftener and conditionerFragranceSurfactant (surface active agent)
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
35 records
| List | Keyword | Source |
|---|---|---|
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 39 of 39 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =2.9 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 4 | unitless | EPA Classification | Inhalation | - | NTP ICE acute inhalation |
| 4 | unitless | EPA Classification | Ocular | Rabbit | NTP ICE eye irritation |
| =3 | Unitless | EPA classification | oral | Rat (Male) | NTP ICE acute oral |
| 4 | unitless | EPA classification | Dermal | Rabbit | NTP ICE skin irritation |
| 18HJT78S09 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 400G2Q040G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5532T1CST6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5P40RLJ3YU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6A70KLA0NP | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 80JPU34G30 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| C0MP061QDX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| K0N34Z34O8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| PBU1N1UU7E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| R199TJT95T | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| V2Z8NAZ8T1 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1 | unitless | GHS Classification | Dermal | Guinea pig | NTP ICE skin sensitization |
| 5 | unitless | GHS classification | Dermal | Rat | NTP ICE acute dermal |
| =5 | Unitless | GHS classification | oral | Rat (Female) | NTP ICE acute oral |
| >2.06 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| >2000 | mg/kg bw | LD50 | oral | Rat (Female) | NTP ICE acute oral |
| >5000 | mg/kg | LD50 | Dermal | Rat | NTP ICE acute dermal |
| ~115 | mg/kg bw/day | LEL | oral | Rabbit | ECHA |
| =150 | mg/kg bw/day | LEL | oral | Rabbit | ECHA |
| =50 | mg/kg bw/day | LOAEL | dermal | Rat | ECHA |
| =250 | mg/kg bw/day | LOAEL | dermal | Rat | ECHA |
| =10 | mg/kg bw/day | NOAEL | dermal | Rat | ECHA |
| =30 | mg/kg bw/day | NOAEL | dermal | Rat | ECHA |
| =50 | mg/kg bw/day | NOAEL | oral | Rabbit | ECHA |
| =80 | mg/kg bw/day | NOAEL | dermal | Rat | ECHA |
| =100 | mg/kg bw/day | NOAEL | dermal | Rat | ECHA |
| =115 | mg/kg bw/day | NOAEL | oral | Rabbit | ECHA |
| =150 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| >=250 | mg/kg bw/day | NOAEL | dermal | Rat | ECHA |
| =300 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =350 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =450 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =600 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =1.2 | mg/kg bw/day | PAD (RfD) | oral | Human | ToxValDB EPA OPP |
Showing 39 of 39 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Poly[oxy(methyl-1,2-ethanediyl)],α-butyl-ω-hydroxy- | 500-003-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Skin Conditioning
Frequently Asked Questions
What regulatory lists include Butoxypolypropylene glycol?
Butoxypolypropylene glycol appears on 6 regulatory/inventory lists including Indirect additives food contact (10/2018), active_ingredient; Pesticides, active_ingredient; Europe; Pesticides, and 3 more. Source: EPA CPDat.
Is Butoxypolypropylene glycol used in cosmetics?
Yes, Butoxypolypropylene glycol is also indexed as a cosmetic ingredient under the name PPG-12 Butyl Ether. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Butoxypolypropylene glycol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Is Butoxypolypropylene glycol used outside industrial chemicals?
Butoxypolypropylene glycol also appears in cosmetics databases.