NOAEL Data Cosmetic Ingredient

Sorbitan, monohexadecanoate, poly(oxy-1,2-ethanediyl) derivs.

Also known as: Polysorbate 40, Tween 40, Polyoxyethylene sorbitan monopalmitate, Polyethylene glycol-sorbitan monopalmitate adduct, Ethoxylated sorbitan monopalmitate (+14 more)

CAS 9005-66-7

Sorbitan, monohexadecanoate, poly(oxy-1,2-ethanediyl) derivs. (CAS 9005-66-7) is a chemical substance. Key regulatory status: 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.

View cosmetic safety profile for Polysorbate 40 →

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 22 fields

Name

Sorbitan, monohexadecanoate, poly(oxy-1,2-ethanediyl) derivs.

CAS Number

9005-66-7

DTXSID

DTXSID70897060

Synonyms

Polysorbate 40Tween 40Polyoxyethylene sorbitan monopalmitatePolyethylene glycol-sorbitan monopalmitate adductEthoxylated sorbitan monopalmitateSorbitan polyethoxy monopalmitateSorbimacrogol palmitate 300Sorbitan monopalmitate polyethylene glycol etherPolyoxyethylene sorbitan monohexadecanoatePolyethylene sorbitan monopalmitatePolyethylene glycol sorbitan monohexadecanoatePolyoxyethylene sorbitol monopalmitate

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 11 records

Surfactant (surface active agent)EmulsifierLubricating agentAnti-static agentDispersing agent

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 5 records

List	Keyword	Source
inert_ingredient; Pesticides	EPA	CPCat
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
pharmaceutical	US International Trade Commission	CPCat
Indirect additives food contact (10/2018)	FDA	United States Food and Drug Administration (FDA)
SCIL (9/2019)	USEPA	Safer Chemical Ingredients List

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 8 of 8 studies

Value	Unit	Endpoint	Route	Species	Source
4NR71FN0IA	UNII	FDA UNII substance identifier	-	-	openFDA substances
4NR71FN0IA	UNII	FDA UNII substance identifier	-	-	openFDA substances
4NR71FN0IA	UNII	FDA UNII substance identifier	-	-	openFDA substances
4NR71FN0IA	UNII	FDA UNII substance identifier	-	-	openFDA substances
STI11B5A2X	UNII	FDA UNII substance identifier	-	-	openFDA substances
STI11B5A2X	UNII	FDA UNII substance identifier	-	-	openFDA substances
STI11B5A2X	UNII	FDA UNII substance identifier	-	-	openFDA substances
STI11B5A2X	UNII	FDA UNII substance identifier	-	-	openFDA substances

Showing 8 of 8 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed

ChEMBL Phase

Not listed

Adverse Events

100

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA 1 records

E434 — ADI: 25 mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Sorbitan, monohexadecanoate, poly(oxy-1,2-ethanediyl) derivs.?

Sorbitan, monohexadecanoate, poly(oxy-1,2-ethanediyl) derivs. has 8 NOAEL studies in the database. The lowest reported value is 4NR71FN0IA UNII. Source: openFDA substances.

What regulatory lists include Sorbitan, monohexadecanoate, poly(oxy-1,2-ethanediyl) derivs.?

Sorbitan, monohexadecanoate, poly(oxy-1,2-ethanediyl) derivs. appears on 5 regulatory/inventory lists including inert_ingredient; Pesticides, inert_ingredient; non_food_use; Pesticides, pharmaceutical, and 2 more. Source: EPA CPDat.

Is Sorbitan, monohexadecanoate, poly(oxy-1,2-ethanediyl) derivs. used in cosmetics?

Yes, Sorbitan, monohexadecanoate, poly(oxy-1,2-ethanediyl) derivs. is also indexed as a cosmetic ingredient under the name Polysorbate 40. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Sorbitan, monohexadecanoate, poly(oxy-1,2-ethanediyl) derivs. come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is Sorbitan, monohexadecanoate, poly(oxy-1,2-ethanediyl) derivs. used outside industrial chemicals?

Sorbitan, monohexadecanoate, poly(oxy-1,2-ethanediyl) derivs. also appears in cosmetics, pharmaceutical, food safety, cannabis databases.