Australian industrial chemicals inventory status and applicable conditions.
SOURCEAICIS inventory1 records
Inventory Status
listed_with_terms
Conditions
Specific information requirements: Obligations to provide information apply. These obligations are: 1. If the assessment report about the chemical recommends secondary notification of the chemical in particular circumstances and any of the circumstances occur in relation to the introduction (importation or manufacture) of the chemical by a person, then the person introducing this chemical must tell us in writing within 28 calendar days that the circumstances have occurred. 2. A person who introduces this chemical must tell us in writing within 28 calendar days if they become aware of any of the following circumstances, namely, that since the assessment under the Industrial Chemicals (Notification and Assessment) Act 1989: a. the function or use of the chemical has changed, or is likely to change, significantly; b. the amount of the chemical being introduced has increased, or is likely to increase, significantly; c. in the case of a chemical not manufactured, or proposed to be manufactured, in Australia at the time of the assessment—it has begun to be manufactured in Australia; d. the method of manufacture of the chemical in Australia has changed, or is likely to change, in a way that may result in an increased risk of an adverse effect of the chemical on occupational health and safety, public health or the environment; e. additional information has become available to the person as to an adverse effect of the chemical on occupational health and safety, public health or the environment.
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
What is the GHS hazard classification for Subtilisin?
Subtilisin (CAS 9014-01-1) is classified under EU CLP Annex VI as STOT SE 3; Skin Irrit. 2; Eye Dam. 1; Resp. Sens. 1 with signal word Danger. Hazard statements: H335; H315; H318; H334. Source: EU CLP Annex VI (ECHA).
What is the NOAEL for Subtilisin?
Subtilisin has 6 NOAEL studies in the database. The lowest reported value is 0ZP13EBC5Y UNII. Source: openFDA substances.
What regulatory lists include Subtilisin?
Subtilisin appears on 5 regulatory/inventory lists including Canada; consumer_product; Substances in Products - Canada (4/2014), inert_ingredient; non_food_use; Pesticides, Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe, and 2 more. Source: EPA CPDat.
Is Subtilisin used in cosmetics?
Yes, Subtilisin is also indexed as a cosmetic ingredient under the name Subtilisin. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Subtilisin come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Does Subtilisin have different safety status in cosmetics vs industrial chemicals?
Subtilisin is classified GHS Danger (H335, H315, H318, H334) in the chemicals database but is allowed in EU cosmetics.