NOAEL Data Cosmetic Ingredient

(2~{R},4~{S},5~{S})-2-[(3~{S},4~{R},6~{R})-6-[(3~{S},4~{R},6~{S})-4,5-dihydroxy-2-(hydroxymethyl)-6-methoxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(methoxymethyl)oxane-3,4,5-triol

Also known as: Pullulan [NF], Pullulan

CAS 9057-02-7

(2~{R},4~{S},5~{S})-2-[(3~{S},4~{R},6~{R})-6-[(3~{S},4~{R},6~{S})-4,5-dihydroxy-2-(hydroxymethyl)-6-methoxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(methoxymethyl)oxane-3,4,5-triol (CAS 9057-02-7) is a chemical substance. Key regulatory status: 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.

View cosmetic safety profile for Pullulan →

SOURCE noael studies public
NOAEL studies
4
SOURCE chemical inventory jurisdictions
Regulatory lists
1
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 5 fields
Name
(2~{R},4~{S},5~{S})-2-[(3~{S},4~{R},6~{R})-6-[(3~{S},4~{R},6~{S})-4,5-dihydroxy-2-(hydroxymethyl)-6-methoxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(methoxymethyl)oxane-3,4,5-triol
CAS Number
9057-02-7
DTXSID
DTXSID301010857
Synonyms
Pullulan [NF]Pullulan

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 7 records
Film formerBinder

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 1 records
ListKeywordSource
Canada; Personal care; Substances in PCP - Canada (4/2014)Government of CanadaCPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 4 of 4 studies
ValueUnitEndpointRouteSpeciesSource
8ZQ0AYU1TTUNIIFDA UNII substance identifier--openFDA substances
8ZQ0AYU1TTUNIIFDA UNII substance identifier--openFDA substances
8ZQ0AYU1TTUNIIFDA UNII substance identifier--openFDA substances
8ZQ0AYU1TTUNIIFDA UNII substance identifier--openFDA substances

Showing 4 of 4 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed_with_terms
Conditions
Specific information requirements: An obligation to provide information applies. The obligation is: 1. A person introducing this chemical must tell us in writing within 28 calendar days if the polymer is imported or manufactured by them in a form that does not meet the polymer of low concern (PLC) criteria

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
0.5–5%
Category
thickener
View full cosmetic safety profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

E1204 — ADI: NOT SPECIFIED mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for (2~{R},4~{S},5~{S})-2-[(3~{S},4~{R},6~{R})-6-[(3~{S},4~{R},6~{S})-4,5-dihydroxy-2-(hydroxymethyl)-6-methoxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(methoxymethyl)oxane-3,4,5-triol?

(2~{R},4~{S},5~{S})-2-[(3~{S},4~{R},6~{R})-6-[(3~{S},4~{R},6~{S})-4,5-dihydroxy-2-(hydroxymethyl)-6-methoxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(methoxymethyl)oxane-3,4,5-triol has 4 NOAEL studies in the database. The lowest reported value is 8ZQ0AYU1TT UNII. Source: openFDA substances.

What regulatory lists include (2~{R},4~{S},5~{S})-2-[(3~{S},4~{R},6~{R})-6-[(3~{S},4~{R},6~{S})-4,5-dihydroxy-2-(hydroxymethyl)-6-methoxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(methoxymethyl)oxane-3,4,5-triol?

(2~{R},4~{S},5~{S})-2-[(3~{S},4~{R},6~{R})-6-[(3~{S},4~{R},6~{S})-4,5-dihydroxy-2-(hydroxymethyl)-6-methoxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(methoxymethyl)oxane-3,4,5-triol appears on 1 regulatory/inventory list including Canada; Personal care; Substances in PCP - Canada (4/2014). Source: EPA CPDat.

Is (2~{R},4~{S},5~{S})-2-[(3~{S},4~{R},6~{R})-6-[(3~{S},4~{R},6~{S})-4,5-dihydroxy-2-(hydroxymethyl)-6-methoxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(methoxymethyl)oxane-3,4,5-triol used in cosmetics?

Yes, (2~{R},4~{S},5~{S})-2-[(3~{S},4~{R},6~{R})-6-[(3~{S},4~{R},6~{S})-4,5-dihydroxy-2-(hydroxymethyl)-6-methoxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(methoxymethyl)oxane-3,4,5-triol is also indexed as a cosmetic ingredient under the name Pullulan. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for (2~{R},4~{S},5~{S})-2-[(3~{S},4~{R},6~{R})-6-[(3~{S},4~{R},6~{S})-4,5-dihydroxy-2-(hydroxymethyl)-6-methoxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(methoxymethyl)oxane-3,4,5-triol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is (2~{R},4~{S},5~{S})-2-[(3~{S},4~{R},6~{R})-6-[(3~{S},4~{R},6~{S})-4,5-dihydroxy-2-(hydroxymethyl)-6-methoxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(methoxymethyl)oxane-3,4,5-triol used outside industrial chemicals?

(2~{R},4~{S},5~{S})-2-[(3~{S},4~{R},6~{R})-6-[(3~{S},4~{R},6~{S})-4,5-dihydroxy-2-(hydroxymethyl)-6-methoxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(methoxymethyl)oxane-3,4,5-triol also appears in cosmetics, food safety, cannabis databases.