What is the NOAEL for Amaranth?
Amaranth has 29 NOAEL studies in the database. The lowest reported value is 0.15 mg/kg bw/day in Consumers. Source: EFSA.
NOAEL Data
IARC Group 3
REACH Registered
Cosmetic Ingredient
Amaranth
Also known as: FD & C Red No. 2, C.I. Acid Red 27, trisodium salt, 2,7-Naphthalenedisulfonic acid, 3-hydroxy-4-((4-sulfo-1-naphthyl)azo)-, trisodium salt, D and C Red 2, Acetacid Red 2BR (+15 more)
CAS 915-67-3
Amaranth (CAS 915-67-3) is a chemical substance; key hazard signal: IARC Group 3. Key regulatory status: REACH registered, 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH.
SOURCE
NOAEL studies
NOAEL studies
29
SOURCE
Chemical inventory jurisdictions
Regulatory lists
8
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Amaranth
CAS Number
915-67-3
DTXSID
DTXSID2021232
Molecular Formula
C20H14N2O10S3.3Na
InChI Key
WLDHEUZGFKACJH-FAIYXUOWSA-K
Monoisotopic Mass
606.950366
Synonyms
FD & C Red No. 2C.I. Acid Red 27, trisodium salt2,7-Naphthalenedisulfonic acid, 3-hydroxy-4-((4-sulfo-1-naphthyl)azo)-, trisodium saltD and C Red 2Acetacid Red 2BRAcid Leather Red I 2BWAcid Leather Rubine SAcilan Red SEAmaranth ExtraAzo Rubine S.FQAzorubine SBordeaux S Extra Conc. A Export
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1987 | 8, Sup 7 |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
59 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
8 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bath salts | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - hair styling and care - shampoo | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bubble bath | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| banned; Europe; Personal care | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 29 of 29 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =0.15 | mg/kg bw/day | ADI | - | Consumers | EFSA |
| =0.15 | mg/kg bw/day | ADI | - | Consumers | EFSA |
| <=0.5 | mg/kg | ADI | oral | Human | WHO/JECFA |
| 37RBV3X49K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 37RBV3X49K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 37RBV3X49K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 37RBV3X49K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP ICE cancer |
| =6000 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =10 | mg/kg bw/day | LOEL | oral | Mouse | ToxValDB ECOTOX |
| =47 | mg/kg bw/day | LOEL | oral | Rat | ECHA |
| =15 | mg/kg bw/day | NOAEL | oral | Rabbit | ECHA |
| =15 | mg/kg bw/day | NOAEL | oral | Rat | EFSA |
| =15 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA |
| =15 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA |
| =47 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =50 | mg/kg bw/day | NOAEL | oral | Mouse | ECHA |
| =100 | mg/kg bw/day | NOAEL | oral | Mouse | ECHA |
| =150 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =1250 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =1260 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =1850 | mg/kg bw/day | NOAEL | oral | Mouse | ECHA |
| =2462 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =3120 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =3700 | mg/kg bw/day | NOAEL | oral | Mouse | ECHA |
| =1 | mg/kg bw/day | NOEL | oral | Mouse | ToxValDB ECOTOX |
| =50 | mg/kg bw/day | NOEL | oral | Mouse | ECHA |
| =1000 | mg/L | NOEL | environmental | Rat | ToxValDB ECOTOX |
Showing 29 of 29 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Trisodium 3-hydroxy-4-(4'-sulphonatonaphthylazo)naphthalene-2,7-disulphonate | 213-022-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Colorants
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
E123 — ADI: 0.15 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Amaranth?
Amaranth appears on 7 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, children; Europe; Personal care, children; Europe; Personal care - specialized bath products - bath salts, and 4 more. Source: EPA CPDat.
Is Amaranth a carcinogen according to IARC?
Amaranth is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1987). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Is Amaranth used in cosmetics?
Yes, Amaranth is also indexed as a cosmetic ingredient under the name CI 16185. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Amaranth come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Amaranth used outside industrial chemicals?
Amaranth also appears in cosmetics, food safety, cannabis databases.