NOAEL Data IARC Group 2A Prop 65 REACH Registered Cosmetic Ingredient

Methyleugenol

Also known as: Benzene, 1,2-dimethoxy-4-(2-propenyl)-, 4-Allyl-1,2-dimethoxybenzene, BRN 1910871, Caswell No. 579AB, 1,2-Dimethoxy-4-(2-propen-1-yl)benzene (+6 more)

CAS 93-15-2

Methyleugenol (CAS 93-15-2) is a chemical substance; key hazard signal: IARC Group 2A. Key regulatory status: California Proposition 65, REACH registered, 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, CA Prop 65, EPA TRI.

View cosmetic safety profile for Methyl Eugenol →

Cross-Vertical Regulatory Divergence

Methyleugenol is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H317, H341, H351, H350, H316, H320, H373).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 17 fields

Name

Methyleugenol

CAS Number

93-15-2

DTXSID

DTXSID5025607

Molecular Formula

C11H14O2

InChI Key

ZYEMGPIYFIJGTP-UHFFFAOYSA-N

Monoisotopic Mass

178.09938

Synonyms

Benzene, 1,2-dimethoxy-4-(2-propenyl)-4-Allyl-1,2-dimethoxybenzeneBRN 1910871Caswell No. 579AB1,2-Dimethoxy-4-(2-propen-1-yl)benzeneEINECS 202-223-0EPA Pesticide Chemical Code 203900FEMA No. 2475FEMA Number 2475O-Methyl eugenolUNII-29T9VA6R7M

IARC Carcinogen Classification

Carcinogenic hazard classification from IARC monograph evaluations.

SOURCE IARC Monographs on the Identification of Carcinogenic Hazards to Humans 1 records

Group	Meaning	Evaluated	Volume
Group 2A	Probably carcinogenic	2023	101, 134

California Proposition 65

California OEHHA listing status and toxicity category.

SOURCE California OEHHA Proposition 65 List 1 records

Chemical	Toxicity Type	Cancer	Developmental	Listed
-	cancer	Yes	No	-

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 15 records

DeodorizerFragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 8 records

List	Keyword	Source
Europe; Personal care; restricted	European Commission	CosIng
IFRA Transparency	IFRA	IFRA
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
active_ingredient; Pesticides	California Department of Pesticide Regulation	State of California
active_ingredient; Australia	Australian Pesticides and Veterinary Medicines Authority	CPCat
detected; Europe; Personal care - make-up and related	Danish Environmental Protection Agency	Danish EPA
OEHHA Proposition 65 (3/2019)	STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY	OEHHA Proposition 65 List
OEHHA Proposition 65 (1/2023)	California Office of Environmental Health Hazard Assessment	OEHHA Proposition 65 List

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 62 studies

Value	Unit	Endpoint	Route	Species	Source
ABcancer	listing type	California Proposition 65 listing	-	-	California Proposition 65
ABcancer	listing type	California Proposition 65 listing	-	-	California Proposition 65
ABcancer	listing type	California Proposition 65 listing	-	-	California Proposition 65
ABcancer	listing type	California Proposition 65 listing	-	-	California Proposition 65
26.56	uL/min/10^6 cells	Clint	-	Human	NTP_ICE_adme_parameters
=9.87	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
4	unitless	EPA Classification	Ocular	Rabbit	NTP_ICE_eye_irritation
4	unitless	EPA classification	Dermal	Rat	NTP_ICE_acute_dermal
=4	Unitless	EPA classification	oral	Rat (Female)	NTP_ICE_acute_oral
4	unitless	EPA classification	Dermal	Rabbit	NTP_ICE_skin_irritation
29T9VA6R7M	UNII	FDA UNII substance identifier	-	-	openFDA substances
29T9VA6R7M	UNII	FDA UNII substance identifier	-	-	openFDA substances
29T9VA6R7M	UNII	FDA UNII substance identifier	-	-	openFDA substances
29T9VA6R7M	UNII	FDA UNII substance identifier	-	-	openFDA substances
0.1416	fraction	Fu	-	Human	NTP_ICE_adme_parameters
5	unitless	GHS classification	Dermal	Rat	NTP_ICE_acute_dermal
=5	Unitless	GHS classification	oral	Rat (Female)	NTP_ICE_acute_oral
2A	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs
2	unitless	IARC group	-	-	NTP_ICE_cancer
-	%	Incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
5184	ug/cm2	Induction dose per skin area	Dermal	Human	NTP_ICE_skin_sensitization
>4.8	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
>5000	mg/kg	LD50	Dermal	Rat	NTP_ICE_acute_dermal
>5000	mg/kg bw	LD50	oral	Rat (Female)	NTP_ICE_acute_oral
=10	mg/kg bw/day	LEL	oral	rat (fischer; Fischer 344)	ToxRefDB_ToxRefDB_v3_pod.csv
=30	mg/kg bw/day	LEL	oral	Mouse	ToxValDB_ToxRefDB
=30	mg/kg bw/day	LEL	oral	mouse (b6c3f1; B6C3F1)	ToxRefDB_ToxRefDB_v3_pod.csv
=37	mg/kg bw/day	LEL	oral	rat (fischer; Fischer 344)	ToxRefDB_ToxRefDB_v3_pod.csv
10	mg/kg bw/day	LOAEL	oral	rat	COSMOS_DB
30	mg/kg bw/day	LOAEL	oral	mouse	COSMOS_DB
=75	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ToxRefDB
=75	mg/kg bw/day	LOAEL	oral	rat (fischer; Fischer 344)	ToxRefDB_ToxRefDB_v3_pod.csv
=80	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=300	mg/kg bw/day	LOAEL	oral	Mouse	ToxValDB_ToxRefDB
=300	mg/kg bw/day	LOAEL	oral	rat (fischer; Fischer 344)	ToxRefDB_ToxRefDB_v3_pod.csv
=9	mg/kg bw/day	LOEL	oral	Mouse	ToxValDB_ECOTOX
=37	mg/kg bw/day	LOEL	oral	Rat	ToxValDB_ECHA_IUCLID
=37	mg/kg bw/day	LOEL	oral	Rat	ToxValDB_ECOTOX
=100	mg/kg bw/day	LOEL	injection	Rat	ToxValDB_ECOTOX
=300	mg/kg bw/day	LOEL	oral	Rat	ToxValDB_ECOTOX
-	unitless	Model Score	-	-	NTP_ICE_endocrine
>-	mg/kg bw/day	NEL	oral	rat (fischer; Fischer 344)	ToxRefDB_ToxRefDB_v3_pod.csv
=10	mg/kg bw/day	NEL	oral	mouse (b6c3f1; B6C3F1)	ToxRefDB_ToxRefDB_v3_pod.csv
10	mg/kg bw/day	NOAEL	oral	mouse	COSMOS_DB
18	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
30	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
37	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
=100	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ToxRefDB
=100	mg/kg bw/day	NOAEL	oral	rat (fischer; Fischer 344)	ToxRefDB_ToxRefDB_v3_pod.csv
300	mg/kg bw/day	NOAEL	oral	mouse	COSMOS_DB

Showing 50 of 62 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	4-allylveratrole	202-223-0	ECHA overview →

EPA Toxic Release Inventory (TRI)

TRI hazard and reporting flags for the matched chemical.

SOURCE EPA Toxics Release Inventory (TRI) chemical list 1 records

Chemical	Category	Flags
Methyleugenol	-	-

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL METHYLEUGENOL

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

1 food-safety record found.

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Methyleugenol?

Methyleugenol has 62 NOAEL studies in the database. The lowest reported value is cancer listing type. Source: California Proposition 65.

What regulatory lists include Methyleugenol?

Methyleugenol appears on 8 regulatory/inventory lists including Europe; Personal care; restricted, IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 5 more. Source: EPA CPDat.

Is Methyleugenol a carcinogen according to IARC?

Methyleugenol is classified by IARC as Group 2A — probably carcinogenic to humans (evaluated 2023). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.

Is Methyleugenol on the California Proposition 65 list?

Yes, Methyleugenol is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.

Is Methyleugenol used in cosmetics?

Yes, Methyleugenol is also indexed as a cosmetic ingredient under the name Methyl Eugenol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Methyleugenol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, California Proposition 65, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Methyleugenol have different safety status in cosmetics vs industrial chemicals?

Methyleugenol is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H317, H341, H351, H350, H316, H320, H373).

Is Methyleugenol used outside industrial chemicals?

Methyleugenol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.