NOAEL Data REACH Registered Cosmetic Ingredient

Methyl benzoate

Also known as: EINECS 202-259-7, Essence of niobe, FEMA No. 2683, Oil of niobe, Methylester kyseliny benzoove (+1 more)

CAS 93-58-3

Methyl benzoate (CAS 93-58-3) is a chemical substance. Key regulatory status: REACH registered, 14 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.

View cosmetic safety profile for Methyl Benzoate →

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 11 fields

Name

Methyl benzoate

CAS Number

93-58-3

Molecular Formula

C8H8O2

InChI Key

QPJVMBTYPHYUOC-UHFFFAOYSA-N

Monoisotopic Mass

136.052429

Synonyms

EINECS 202-259-7Essence of niobeFEMA No. 2683Oil of niobeMethylester kyseliny benzooveUNII-6618K1VJ9T

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE WHO/JECFA 1 records

Field	Value
GHS Signal Word	WARNING
GHS Hazard Statements	Combustible liquid Harmful to aquatic life
Short-term Effects	The substance may cause effects on the central nervous system. This may result in impaired functions.
Routes of Exposure	The substance can be absorbed into the body by inhalation of its vapour.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records

SolventPreservativeSoftener and conditionerFragranceNo specific technical functionFlavouring and nutrientBiocide

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 14 records

List	Keyword	Source
artificial_saliva; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; Europe	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - sexual wellness	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - sexual wellness	Danish Environmental Protection Agency	Danish EPA
air; Cleaning products and household care - laundry and fabric treatment; detected; emissions	Elsevier	CPCat
air; Cleaning products and household care - air freshener; detected; emissions	Elsevier	CPCat
Australia; Food and drug - smoking-related products	New Zealand ESR	CPCat
IFRA Transparency	IFRA	IFRA
Europe	European Commission	Fl@vis
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
SCIL (9/2019)	USEPA	Safer Chemical Ingredients List
consumer_product	P&G	Proctor & Gamble
active_ingredient; animal_products; Europe; pharmaceutical; residue	EU	CPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 26 of 26 studies

Value	Unit	Endpoint	Route	Species	Source
=39.3	mg/m3	DNEL systemic	inhalation	Human	ToxValDB GESTIS DNEL
6618K1VJ9T	UNII	FDA UNII substance identifier	-	-	openFDA substances
0	%	Incidence of positive responses	Dermal	Human	NTP ICE skin sensitization
2592	ug/cm2	Induction dose per skin area	Dermal	Human	NTP ICE skin sensitization
=1177	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
=1625	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
=2000	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
=3400	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
<4000	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
=1	%	NOAEL	oral	rat	CIR Safety Assessment
=125	mg/kg/d	NOAEL	oral	rat	CIR Safety Assessment
=130	mg/kg/d	NOAEL	-	rat	CIR Safety Assessment
=175	mg/kg	NOAEL	oral	rat	CIR Safety Assessment
=200	mg/kg/d	NOAEL	oral	rat	CIR Safety Assessment
=850	mg/m3	NOAEL	oral	rat	CIR Safety Assessment
=1000	mg/kg/d	NOAEL	oral	rat	CIR Safety Assessment
=1230	mg/m3	NOAEL	oral	rat	CIR Safety Assessment
3	unitless	Relative reliability score	Dermal	Human	NTP ICE skin sensitization
1	%	developmental toxicity	oral	rat	Regulatory source
130	mg/kg/d	developmental toxicity	-	rat	Regulatory source
175	mg/kg	developmental toxicity	oral	rat	Regulatory source
850	mg/m3	developmental toxicity	oral	rat	Regulatory source
1230	mg/m3	inhalation toxicity	oral	rat	Regulatory source
1000	mg/kg/d	oral toxicity	oral	rat	Regulatory source
125	mg/kg/d	repeated dose toxicity	oral	rat	Regulatory source
200	mg/kg/d	repeated dose toxicity	oral	rat	Regulatory source

Showing 26 of 26 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records

Status	Name	EC Number	Link
Registered	Methyl benzoate	202-259-7	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed METHYL BENZOATE

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Methyl benzoate?

Methyl benzoate has 26 NOAEL studies in the database. The lowest reported value is 39.3 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.

What regulatory lists include Methyl benzoate?

Methyl benzoate appears on 13 regulatory/inventory lists including artificial_saliva; detected; emissions; Europe; Other direct contact consumer goods, air; detected; emissions; Europe; Other direct contact consumer goods, Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; Europe, and 10 more. Source: EPA CPDat.

Is Methyl benzoate used in cosmetics?

Yes, Methyl benzoate is also indexed as a cosmetic ingredient under the name Methyl Benzoate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Methyl benzoate come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is Methyl benzoate used outside industrial chemicals?

Methyl benzoate also appears in cosmetics, pharmaceutical, cannabis databases.