What is the NOAEL for Methyl benzoate?
Methyl benzoate has 53 NOAEL studies in the database. The lowest reported value is 39.3 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
Also known as: EINECS 202-259-7, Essence of niobe, FEMA No. 2683, Oil of niobe, Methylester kyseliny benzoove (+1 more)
CAS 93-58-3
Methyl benzoate (CAS 93-58-3) is a chemical substance. Key regulatory status: REACH registered, 14 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
CAS, identifiers, formula, and alternate names for the matched substance record.
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| GHS Signal Word | WARNING |
| GHS Hazard Statements | Combustible liquid Harmful to aquatic life |
| Short-term Effects | The substance may cause effects on the central nervous system. This may result in impaired functions. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its vapour. |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| artificial_saliva; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| air; Cleaning products and household care - laundry and fabric treatment; detected; emissions | Elsevier | CPCat |
| air; Cleaning products and household care - air freshener; detected; emissions | Elsevier | CPCat |
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| consumer_product | P&G | Proctor & Gamble |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =39.3 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 6618K1VJ9T | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6618K1VJ9T | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6618K1VJ9T | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6618K1VJ9T | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2592 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =1177 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =1625 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =3400 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| <4000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =1 | % | NOAEL | oral | rat | CIR_vision_codex |
| =1 | % | NOAEL | oral | rat | CIR_vision_codex |
| =1 | % | NOAEL | oral | rat | CIR_vision_codex |
| =1 | % | NOAEL | oral | rat | CIR_vision_codex |
| =125 | mg/kg/d | NOAEL | oral | rat | CIR_vision_codex |
| =125 | mg/kg/d | NOAEL | oral | rat | CIR_vision_codex |
| =125 | mg/kg/d | NOAEL | oral | rat | CIR_vision_codex |
| =125 | mg/kg/d | NOAEL | oral | rat | CIR_vision_codex |
| =130 | mg/kg/d | NOAEL | - | rat | CIR_vision_codex |
| =130 | mg/kg/d | NOAEL | - | rat | CIR_vision_codex |
| =130 | mg/kg/d | NOAEL | - | rat | CIR_vision_codex |
| =130 | mg/kg/d | NOAEL | - | rat | CIR_vision_codex |
| =175 | mg/kg | NOAEL | oral | rat | CIR_vision_codex |
| =175 | mg/kg | NOAEL | oral | rat | CIR_vision_codex |
| =175 | mg/kg | NOAEL | oral | rat | CIR_vision_codex |
| =175 | mg/kg | NOAEL | oral | rat | CIR_vision_codex |
| =200 | mg/kg/d | NOAEL | oral | rat | CIR_vision_codex |
| =200 | mg/kg/d | NOAEL | oral | rat | CIR_vision_codex |
| =200 | mg/kg/d | NOAEL | oral | rat | CIR_vision_codex |
| =200 | mg/kg/d | NOAEL | oral | rat | CIR_vision_codex |
| =850 | mg/m3 | NOAEL | oral | rat | CIR_vision_codex |
| =850 | mg/m3 | NOAEL | oral | rat | CIR_vision_codex |
| =850 | mg/m3 | NOAEL | oral | rat | CIR_vision_codex |
| =850 | mg/m3 | NOAEL | oral | rat | CIR_vision_codex |
| =1000 | mg/kg/d | NOAEL | oral | rat | CIR_vision_codex |
| =1000 | mg/kg/d | NOAEL | oral | rat | CIR_vision_codex |
| =1000 | mg/kg/d | NOAEL | oral | rat | CIR_vision_codex |
| =1000 | mg/kg/d | NOAEL | oral | rat | CIR_vision_codex |
| =1230 | mg/m3 | NOAEL | oral | rat | CIR_vision_codex |
| =1230 | mg/m3 | NOAEL | oral | rat | CIR_vision_codex |
| =1230 | mg/m3 | NOAEL | oral | rat | CIR_vision_codex |
| =1230 | mg/m3 | NOAEL | oral | rat | CIR_vision_codex |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
| 1 | % | developmental toxicity | oral | rat | UnifiedCodex:CIR:beta.noael_studies |
| 130 | mg/kg/d | developmental toxicity | - | rat | UnifiedCodex:CIR:beta.noael_studies |
| 175 | mg/kg | developmental toxicity | oral | rat | UnifiedCodex:CIR:beta.noael_studies |
| 850 | mg/m3 | developmental toxicity | oral | rat | UnifiedCodex:CIR:beta.noael_studies |
| 1230 | mg/m3 | inhalation toxicity | oral | rat | UnifiedCodex:CIR:beta.noael_studies |
Showing 50 of 53 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Methyl benzoate | 202-259-7 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Same-CAS cannabis compliance and lab records where available.
1 cannabis record found in efsa substances.
View full cannabis profile →Methyl benzoate has 53 NOAEL studies in the database. The lowest reported value is 39.3 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
Methyl benzoate appears on 13 regulatory/inventory lists including artificial_saliva; detected; emissions; Europe; Other direct contact consumer goods, air; detected; emissions; Europe; Other direct contact consumer goods, Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; Europe, and 10 more. Source: EPA CPDat.
Yes, Methyl benzoate is also indexed as a cosmetic ingredient under the name Methyl Benzoate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Methyl benzoate also appears in cosmetics, pharmaceutical, cannabis databases.