What is the NOAEL for Phenyl benzoate?
Phenyl benzoate has 89 NOAEL studies in the database. The lowest reported value is 1.2 % via Dermal in Mouse. Source: NTP_ICE_skin_sensitization.
NOAEL Data
Cosmetic Ingredient
Phenyl benzoate
Also known as: Benzoic acid, phenyl ester, Phenol, benzoate, Phenyl ester benzoic acid, 4-09-00-00303, BRN 1566346 (+4 more)
CAS 93-99-2
Phenyl benzoate (CAS 93-99-2) is a chemical substance. Key regulatory status: 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
SOURCE
noael studies public
NOAEL studies
89
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
15 fields
Name
Phenyl benzoate
CAS Number
93-99-2
DTXSID
DTXSID0048210
Molecular Formula
C13H10O2
InChI Key
FCJSHPDYVMKCHI-UHFFFAOYSA-N
Monoisotopic Mass
198.06808
Synonyms
Benzoic acid, phenyl esterPhenol, benzoatePhenyl ester benzoic acid4-09-00-00303BRN 1566346EINECS 202-293-2UNII-B8A3WVZ590benzoic acid phenyl esterdiphenylcarboxylate
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
PreservativeFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| detected; Europe; Personal care - nails | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| artificial_sweat; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 89 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 236.4 | ug/mL | CD54, EC200 | Dermal | - | NTP_ICE_skin_sensitization |
| 12.468 | ug/mL | CD86, EC120 | Dermal | - | NTP_ICE_skin_sensitization |
| 82 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 100.73 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 137.8 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 166.2 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| >200 | ug/mL | CV70 | Dermal | - | NTP_ICE_skin_sensitization |
| 231.8 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| >500 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 42.8 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 8 | % | Concentration, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| 34.2 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 64.9 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 2.2 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 17 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 33.55 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 203.1 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| >250 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 619.15 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 690.75 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| >2000 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 1.2 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 1.2 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 1.2 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 1.2 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 13.6 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 17.1 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 20 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 20 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 20 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 20 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| B8A3WVZ590 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| B8A3WVZ590 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| B8A3WVZ590 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| B8A3WVZ590 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 160.7 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 181.48 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 185.2 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 185.33 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 188.77 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 191.21 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 191.44 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 191.62 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 195.91 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 196.49 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 210.34 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 239.9 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 263.3 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 299.2 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 309.6 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
Showing 50 of 89 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL1885870
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What regulatory lists include Phenyl benzoate?
Phenyl benzoate appears on 4 regulatory/inventory lists including detected; Europe; Personal care - nails, detected; Europe; Toys and children's products, artificial_sweat; detected; emissions; Europe; Toys and children's products, and 1 more. Source: EPA CPDat.
Is Phenyl benzoate used in cosmetics?
Yes, Phenyl benzoate is also indexed as a cosmetic ingredient under the name Phenyl Benzoate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Phenyl benzoate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Phenyl benzoate used outside industrial chemicals?
Phenyl benzoate also appears in cosmetics, pharmaceutical databases.