What is the NOAEL for P-Synephrine?
P-Synephrine has 4 NOAEL studies in the database. The lowest reported value is PEG5DP7434 UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
P-Synephrine
Also known as: RS)-1-(4-Hydroxyphenyl)-2-(methylamino)ethanol, 4-(1-Hydroxy-2-(methylamino)ethyl)phenol, Benzenemethanol, 4-hydroxy-alpha-((methylamino)methyl)-, Benzyl alcohol, p-hydroxy-alpha-((methylamino)methyl)-, Analeptin (+15 more)
CAS 94-07-5
P-Synephrine (CAS 94-07-5) is a chemical substance. Key regulatory status: 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.
SOURCE
noael studies public
NOAEL studies
4
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
P-Synephrine
CAS Number
94-07-5
DTXSID
DTXSID0030588
Molecular Formula
C9H13NO2
InChI Key
YRCWQPVGYLYSOX-UHFFFAOYSA-N
Monoisotopic Mass
167.094629
Synonyms
RS)-1-(4-Hydroxyphenyl)-2-(methylamino)ethanol4-(1-Hydroxy-2-(methylamino)ethyl)phenolBenzenemethanol, 4-hydroxy-alpha-((methylamino)methyl)-Benzyl alcohol, p-hydroxy-alpha-((methylamino)methyl)-AnaleptinEINECS 202-300-9Ethaphene4-Hydroxy-alpha-((methylamino)methyl)benzenemethanolp-Hydroxy-alpha-((methylamino)methyl)benzyl alcoholp-Hydroxyphenylmethylaminoethanol1-(4-Hydroxyphenyl)-N-methylethanolaminep-Methylaminoethanolphenol
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
Humectant
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| PEG5DP7434 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| PEG5DP7434 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| PEG5DP7434 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| PEG5DP7434 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
OXEDRINE
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
7
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include P-Synephrine?
P-Synephrine appears on 1 regulatory/inventory list including Canada; pharmaceutical. Source: EPA CPDat.
Is P-Synephrine used in cosmetics?
Yes, P-Synephrine is also indexed as a cosmetic ingredient under the name Synephrine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for P-Synephrine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is P-Synephrine used outside industrial chemicals?
P-Synephrine also appears in cosmetics, pharmaceutical, food safety, cannabis databases.