What is the NOAEL for Propylparaben?
Propylparaben has 85 NOAEL studies in the database. The lowest reported value is -9 mg/kg bw/day. Source: Regulatory source.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Propylparaben
Also known as: Propyl-4-hydroxybenzoate, 4-10-00-00374, BRN 1103245, Caswell No. 714, EINECS 202-307-7 (+15 more)
CAS 94-13-3
Propylparaben (CAS 94-13-3) is a chemical substance. Key regulatory status: REACH registered, 43 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Propylparaben is classified GHS Danger (H315, H319, H335, H302, H317, H370, H373, H401) in the chemicals database but is restricted in EU cosmetics at max 0.14% (as acid).
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Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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NOAEL studies
NOAEL studies
85
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Chemical inventory jurisdictions
Regulatory lists
43
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EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
25 fields
Name
Propylparaben
CAS Number
94-13-3
Molecular Formula
C10H12O3
InChI Key
QELSKZZBTMNZEB-UHFFFAOYSA-N
Monoisotopic Mass
180.078644
Synonyms
Propyl-4-hydroxybenzoate4-10-00-00374BRN 1103245Caswell No. 714EINECS 202-307-7EPA Pesticide Chemical Code 061203FEMA No. 2951FEMA Number 2951p-OxybenzoesaurepropylesterPropylester kyseliny p-hydroxybenzooveUNII-Z8IX2SC1OHBayer D 206
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
PreservativeFragranceFood preservativeSoftener and conditioner
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
43 records
| List | Keyword | Source |
|---|---|---|
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe | Danish Environmental Protection Agency | Danish EPA |
| detected; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| detected; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| detected; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| detected; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| detected; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| detected; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| detected; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| Personal care; Southeast Asia | Asean | ASEAN Cosmetics |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
| children; WA Children's Safe Product Act (4/2020) | State of Washington Department of Ecology | State of Washington |
| children | Vermont Department of Health | State of Vermont |
| children | Maine Department of Environmental Protection | State of Maine |
| Europe; Food contact items | Danish Environmental Protection Agency | Danish EPA |
| Europe; restricted | Danish Environmental Protection Agency | Danish EPA |
| children | Oregon Health Authority | State of Oregon |
| artificial_sweat; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| Europe; pharmaceutical | Danish Environmental Protection Agency | Danish EPA |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| detected; Personal care; Southeast Asia | Asean | ASEAN Cosmetics |
| Europe; Personal care - body hygiene - hand soap | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bath salts | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - general moisturizing - hand/body lotion | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - body hygiene - body wash | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - hair styling and care - shampoo | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bubble bath | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - dental care - toothpaste | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| detected; Europe; Other direct contact consumer goods - apparel | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 85 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| -9 | - | - | - | - | Regulatory source |
| 0 | - | - | - | - | Regulatory source |
| 0.036 | - | - | - | - | Regulatory source |
| 1 | - | - | - | mouse | Regulatory source |
| 2 | - | - | - | - | Regulatory source |
| 6.5 | - | - | - | mouse | Regulatory source |
| 9 | - | - | - | - | Regulatory source |
| 12.4 | mg/kg/day | - | - | - | Regulatory source |
| 17 | mg/kg | - | - | - | Regulatory source |
| 17 | - | - | - | - | Regulatory source |
| 20 | mg/kg bw | - | - | rat | Regulatory source |
| 33 | mg/kg bw | - | - | - | Regulatory source |
| 38 | % | - | - | - | Regulatory source |
| 43 | mg/kg bw | - | - | mouse | Regulatory source |
| 50 | - | - | - | mouse | Regulatory source |
| 50 | - | - | - | rat | Regulatory source |
| 62.5 | mg/kg/day | - | - | rat | Regulatory source |
| 100 | mg/kg | - | oral | rat | Regulatory source |
| 100 | mg/kg | - | oral | mouse | Regulatory source |
| 195 | mg/kg | - | - | - | Regulatory source |
| 250 | mg/kg bw/day | - | - | - | Regulatory source |
| 1000 | mg/kg | - | - | - | Regulatory source |
| 1000 | mg/kg/day | - | oral | mouse | Regulatory source |
| 1000 | mg/kg/day | - | - | - | Regulatory source |
| 20.58 | uM | AC50 | - | - | NTP ICE endocrine |
| 3.900e+4 | nM | AC50/EC50/IC50 | - | - | NTP ICE endocrine |
| 7.010e+4 | nM | AC50/EC50/IC50 | - | - | NTP ICE endocrine |
| 8.600e+4 | nM | AC50/EC50/IC50 | - | - | NTP ICE endocrine |
| 3.100e+5 | nM | AC50/EC50/IC50 | - | - | NTP ICE endocrine |
| 9.700e+5 | nM | AC50/EC50/IC50 | - | - | NTP ICE endocrine |
| 4.28 | uM | ACC | - | - | NTP ICE endocrine |
| 70.8 | ug/mL | CD54, EC200 | Dermal | - | NTP ICE skin sensitization |
| 83 | ug/mL | CD54, EC200 | Dermal | - | NTP ICE skin sensitization |
| 23.91 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 54 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 61.4 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 121.7 | ug/mL | CV70 | Dermal | - | NTP ICE skin sensitization |
| 106.7 | ug/mL | CV75 | Dermal | - | NTP ICE skin sensitization |
| 132.6 | ug/mL | CV75 | Dermal | - | NTP ICE skin sensitization |
| 38 | uL/min/10^6 cells | Clint | - | Human | NTP ICE adme parameters |
| 246 | uL/min/10^6 cells | Clint | - | Rat | NTP ICE adme parameters |
| 30.63 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 6.25 | % | Concentration, one positive response | Dermal | Human | NTP ICE skin sensitization |
| =88.2 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| -1.5 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| 8.2 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| -1.3 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| -0.2 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 0.3 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 0 | % | Depletion Lys + Cys | Dermal | - | NTP ICE skin sensitization |
Showing 50 of 85 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Propyl 4-hydroxybenzoate | 202-307-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
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SCCS Opinion
1 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1623/20 | 30-31 March 2021 | Safe — safe at 0.14%; in mixtures sum of propyl+butyl not to exceed 0.14% | 0.14% (as acid); in mixtures: sum of propyl+butyl ≤0.14% | Endocrine disruption potential (some indications in vitro but not conclusive); not classified as endocrine disruptor; no reproductive toxicity at cosmetic-use concentrations |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
restricted
Max
0.14% (as acid)
Category
preservative
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
PROPYLPARABEN
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
3
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
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EFSA
1 records
E216 — ADI: 10 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
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Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Propylparaben?
Propylparaben appears on 31 regulatory/inventory lists including Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe, detected; Toys and children's products, active_ingredient; Europe; Pesticides, and 28 more. Source: EPA CPDat.
Is Propylparaben used in cosmetics?
Yes, Propylparaben is also indexed as a cosmetic ingredient under the name Propylparaben. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Propylparaben come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Propylparaben have different safety status in cosmetics vs industrial chemicals?
Propylparaben is classified GHS Danger (H315, H319, H335, H302, H317, H370, H373, H401) in the chemicals database but is restricted in EU cosmetics at max 0.14% (as acid).
Is Propylparaben used outside industrial chemicals?
Propylparaben also appears in cosmetics, pharmaceutical, food safety, cannabis databases.