What is the NOAEL for Benzyl 4-hydroxybenzoate?
Benzyl 4-hydroxybenzoate has 20 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP_ICE_endocrine.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Benzyl 4-hydroxybenzoate
Also known as: Benzylparaben, Benzoic acid, 4-hydroxy-, phenylmethyl ester, Benzyl Parasept, Benzyl Tegosept, Benzyl-Parasept (+8 more)
CAS 94-18-8
Benzyl 4-hydroxybenzoate (CAS 94-18-8) is a chemical substance. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Benzyl 4-hydroxybenzoate is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319, H335).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
20
SOURCE
chemical inventory jurisdictions
Regulatory lists
6
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
19 fields
Name
Benzyl 4-hydroxybenzoate
CAS Number
94-18-8
DTXSID
DTXSID9022526
Molecular Formula
C14H12O3
InChI Key
MOZDKDIOPSPTBH-UHFFFAOYSA-N
Monoisotopic Mass
228.078644
Synonyms
BenzylparabenBenzoic acid, 4-hydroxy-, phenylmethyl esterBenzyl ParaseptBenzyl TegoseptBenzyl-ParaseptEINECS 202-311-9p-Hydroxybenzoic acid benzyl esterNipabenzylNSC 8080ParoseptSolbrol ZUNII-8Y41DYV4VG
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
BiocideFood preservative
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
6 records
| List | Keyword | Source |
|---|---|---|
| banned; Europe; Personal care | European Commission | CosIng |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| detected; Personal care; Southeast Asia | Asean | ASEAN Cosmetics |
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 20 of 20 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 5.84189349377303 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 1.761544913204 | uM | ACC | - | - | NTP_ICE_endocrine |
| 633 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| 639.1 | uL/min/10^6 cells | Clint | - | Rat | NTP_ICE_adme_parameters |
| =0.33 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 8Y41DYV4VG | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8Y41DYV4VG | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8Y41DYV4VG | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8Y41DYV4VG | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.00674 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| =0.16 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =0.16 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_Uterotrophic_Hershberger_DB |
| =100 | mg/day | LEL | dermal | Mouse | ToxValDB_Uterotrophic_Hershberger_DB |
| =33 | mg/kg bw/day | LOAEL | dermal | Mouse | ToxValDB_ECHA_IUCLID |
| 0.16 | mg/kg bw/day | LOEL | Oral | Rat | NTP_ICE_endocrine |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.234 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =10 | mg/kg bw/day | NOAEL | dermal | Mouse | ToxValDB_ECHA_IUCLID |
| =3000 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| 120 | % | Uterine weight increase vs control | Oral | Rat | NTP_ICE_endocrine |
Showing 20 of 20 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Benzyl 4-hydroxybenzoate | 202-311-9 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Preservative
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL447861
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
4
Frequently Asked Questions
What regulatory lists include Benzyl 4-hydroxybenzoate?
Benzyl 4-hydroxybenzoate appears on 5 regulatory/inventory lists including banned; Europe; Personal care, active_ingredient; animal_products; Europe; pharmaceutical; residue, detected; Personal care; Southeast Asia, and 2 more. Source: EPA CPDat.
Is Benzyl 4-hydroxybenzoate used in cosmetics?
Yes, Benzyl 4-hydroxybenzoate is also indexed as a cosmetic ingredient under the name Benzylparaben. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Benzyl 4-hydroxybenzoate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Benzyl 4-hydroxybenzoate have different safety status in cosmetics vs industrial chemicals?
Benzyl 4-hydroxybenzoate is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319, H335).
Is Benzyl 4-hydroxybenzoate used outside industrial chemicals?
Benzyl 4-hydroxybenzoate also appears in cosmetics, pharmaceutical databases.