NOAEL Data REACH Registered Cosmetic Ingredient

O-Cresol

Also known as: 2-Methylphenol, EINECS 202-423-8, FEMA No. 3480, UNII-YW84DH5I7U, 2-cresol (+2 more)

CAS 95-48-7

O-Cresol (CAS 95-48-7) is a chemical substance. Key regulatory status: REACH registered, 14 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, EPA TRI.

View cosmetic safety profile for O-Cresol →

Cross-Vertical Regulatory Divergence

O-Cresol is classified GHS Danger (H301, H311, H314, H412, H318, H335, H361, H372) in the chemicals database but is restricted in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

100

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 13 fields

Name

O-Cresol

CAS Number

95-48-7

DTXSID

DTXSID8021808

Molecular Formula

C7H8O

InChI Key

QWVGKYWNOKOFNN-UHFFFAOYSA-N

Monoisotopic Mass

108.057515

Synonyms

2-MethylphenolEINECS 202-423-8FEMA No. 3480UNII-YW84DH5I7U2-cresolo-cresylic acidorthocresol

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
GHS Signal Word	DANGER
GHS Hazard Statements	Toxic if swallowed or in contact with skin Causes severe skin burns and eye damage Causes damage to central nervous system and blood Causes damage to the nervous system and the blood through prolonged or repeated exposure Toxic to aquatic life
Short-term Effects	The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause lung oedema, but only after initial corrosive effects on eyes and/or airways have become manifest. The substance may cause effects on the central nervous system. This may result in lowering of consciousness. The substance may cause effects on the blood. This may result in destruction of blood cells. Exposure far above the OEL could cause death. Medical observation is indicated.
Long-term Effects	Repeated or prolonged contact with skin may cause dermatitis. The substance may have effects on the nervous system. This may result in impaired functions. The substance may have effects on the blood. This may result in anaemia.
Routes of Exposure	The substance can be absorbed into the body by inhalation, through the skin and by ingestion. Serious local effects by all routes of exposure.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 7 records

BiocideFragranceFlavouring and nutrientSolvent

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 14 records

List	Keyword	Source
air; Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
Cleaning products and household care - air freshener; Europe	Danish Environmental Protection Agency	Danish EPA
air; Cleaning products and household care - air freshener; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
Europe	European Commission	Fl@vis
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
IFRA Transparency	IFRA	IFRA
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
consumer_product	P&G	Proctor & Gamble

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies

Value	Unit	Endpoint	Route	Species	Source
=0.17	mg/kg bw/day	ADI	-	-	INCHEM_WHO_hsg_hsg_hsg100
=0.17	mg/kg bw/day	ADI	-	-	INCHEM_WHO_hsg_hsg_hsg100
=6.9	mg/kg bw/day	BMDL (10 HED)	oral	Rat	ToxValDB_PPRTV_(CPHEA)
-	uL/min/10^6 cells	Clint	-	Rat	NTP_ICE_adme_parameters
27.48	uL/min/10^6 cells	Clint	-	Human	NTP_ICE_adme_parameters
=2.47	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
YW84DH5I7U	UNII	FDA UNII substance identifier	-	-	openFDA substances
YW84DH5I7U	UNII	FDA UNII substance identifier	-	-	openFDA substances
YW84DH5I7U	UNII	FDA UNII substance identifier	-	-	openFDA substances
YW84DH5I7U	UNII	FDA UNII substance identifier	-	-	openFDA substances
0.38	fraction	Fu	-	Human	NTP_ICE_adme_parameters
0.525	fraction	Fu	-	Rat	NTP_ICE_adme_parameters
0.029	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
>1.22	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
=121	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=1350	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=129	mg/kg bw/day	LEL	oral	Rat	ToxValDB_ToxRefDB
=129	mg/kg bw/day	LEL	oral	rat (fischer; Fischer 344)	ToxRefDB_ToxRefDB_v3_pod.csv
=510	mg/kg bw/day	LEL	oral	Rat	ToxValDB_ToxRefDB
=510	mg/kg bw/day	LEL	oral	rat (fischer; Fischer 344)	ToxRefDB_ToxRefDB_v3_pod.csv
=513	mg/kg bw/day	LEL	oral	Rat	ToxValDB_ToxRefDB
=513	mg/kg bw/day	LEL	oral	rat (fischer; Fischer 344)	ToxRefDB_ToxRefDB_v3_pod.csv
=150	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_IRIS
175	mg/kg bw/day	LOAEL	oral	rat	COSMOS_DB
510	mg/kg bw/day	LOAEL	oral	rat	COSMOS_DB
=1017	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ToxRefDB
=1017	mg/kg bw/day	LOAEL	oral	rat (fischer; Fischer 344)	ToxRefDB_ToxRefDB_v3_pod.csv
=1021	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ToxRefDB
=1021	mg/kg bw/day	LOAEL	oral	rat (fischer; Fischer 344)	ToxRefDB_ToxRefDB_v3_pod.csv
=30	mg/kg bw/day	LOEL	oral	Rat	ToxValDB_ECOTOX
=35	mg/kg bw/day	LOEL	injection	Rat	ToxValDB_ECOTOX
=50	mg/kg bw/day	LOEL	oral	European Rabbit	ToxValDB_ECOTOX
=3940	mg/kg bw/day	LOEL	oral	Mouse	ToxValDB_ECOTOX
-	unitless	Model Score	-	-	NTP_ICE_endocrine
>-	mg/kg bw/day	NEL	oral	rat (fischer; Fischer 344)	ToxRefDB_ToxRefDB_v3_pod.csv
=247	mg/kg bw/day	NEL	oral	Rat	ToxValDB_ToxRefDB
=247	mg/kg bw/day	NEL	oral	rat (fischer; Fischer 344)	ToxRefDB_ToxRefDB_v3_pod.csv
=256	mg/kg bw/day	NEL	oral	Rat	ToxValDB_ToxRefDB
=256	mg/kg bw/day	NEL	oral	rat (fischer; Fischer 344)	ToxRefDB_ToxRefDB_v3_pod.csv
=27	mg/kg bw/day	NOAEL	-	-	INCHEM_WHO_kemi_kemi_ah1998_27
=27	mg/kg bw/day	NOAEL	-	-	INCHEM_WHO_kemi_kemi_ah1998_27
=27	mg/kg bw/day	NOAEL	-	-	INCHEM_WHO_kemi_kemi_ah1998_27
=27	mg/kg bw/day	NOAEL	-	-	INCHEM_WHO_kemi_kemi_ah1998_27
=30	mg/kg bw/day	NOAEL	-	-	INCHEM_WHO_kemi_kemi_ah1998_27
=30	mg/kg bw/day	NOAEL	-	-	INCHEM_WHO_kemi_kemi_ah1998_27
=30	mg/kg bw/day	NOAEL	-	-	INCHEM_WHO_kemi_kemi_ah1998_27
=30	mg/kg bw/day	NOAEL	-	-	INCHEM_WHO_kemi_kemi_ah1998_27
50	mg/kg bw/day	NOAEL	oral	rabbit	COSMOS_DB
=50	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_Cal_OEHHA_REL_derivations
=50	mg/kg/day	NOAEL	oral	-	EPA_IRIS_iris_rfd_systems.csv

Showing 50 of 100 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	o-cresol	202-423-8	ECHA overview →

EPA Toxic Release Inventory (TRI)

TRI hazard and reporting flags for the matched chemical.

SOURCE EPA Toxics Release Inventory (TRI) chemical list 1 records

Chemical	Category	Flags
o-Cresol	-	-

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL ORTHOCRESOL

ChEMBL Phase

-1

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for O-Cresol?

O-Cresol has 100 NOAEL studies in the database. The lowest reported value is 0 uL/min/10^6 cells in Rat. Source: NTP_ICE_adme_parameters.

What regulatory lists include O-Cresol?

O-Cresol appears on 9 regulatory/inventory lists including air; Cons electronics mech appliances and machinery; detected; emissions; Europe, Cleaning products and household care - air freshener; Europe, air; Cleaning products and household care - air freshener; detected; emissions; Europe, and 6 more. Source: EPA CPDat.

Is O-Cresol used in cosmetics?

Yes, O-Cresol is also indexed as a cosmetic ingredient under the name O-Cresol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for O-Cresol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does O-Cresol have different safety status in cosmetics vs industrial chemicals?

O-Cresol is classified GHS Danger (H301, H311, H314, H412, H318, H335, H361, H372) in the chemicals database but is restricted in EU cosmetics.

Is O-Cresol used outside industrial chemicals?

O-Cresol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.