Also known as: CI Oxidation Base 17, EINECS 202-431-1, 2-Hydroxyanaline, Nako Yellow ga, Questiomycin B (+1 more)
CAS 95-55-6
2-Aminophenol (CAS 95-55-6) is a chemical substance with GHS signal word Warning; key hazard signal: H341; H332; H302. Key regulatory status: REACH registered, 11 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH, ILO ICSC.
2-Aminophenol is classified GHS CMR hazard (H341, H332, H302) in the chemicals database but is restricted in EU cosmetics at max 2.0%.
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Muta. 2; Acute Tox. 4 *; Acute Tox. 4 * | H341; H332; H302 | GHS08; GHS07 | Warning |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| Short-term Effects | The substance may cause effects on the blood. This may result in the formation of methaemoglobin. The effects may be delayed. Medical observation is indicated. |
| Long-term Effects | Repeated or prolonged contact may cause skin sensitization. |
| Routes of Exposure | The substance can be absorbed into the body by ingestion, through the skin and by inhalation of its aerosol. |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| Canada; pharmaceutical | DrugBank | DrugBank |
| detected; Europe; Personal care - hair coloring - hair color - professional | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - hair coloring - hair color - professional | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - hair coloring - hair color - professional | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| - | Danish Environmental Protection Agency | Danish EPA |
| - | Danish Environmental Protection Agency | Danish EPA |
| - | Danish Environmental Protection Agency | Danish EPA |
| - | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 70 | mg/kg bw/d | - | - | human | Regulatory source |
| <0.1 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 0.32 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 1.1 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 8.02 | ug/mL | CV70 | Dermal | - | NTP ICE skin sensitization |
| 6 | ug/mL | CV75 | Dermal | - | NTP ICE skin sensitization |
| 96.2 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| 18.1 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 57.15 | % | Depletion Lys + Cys | Dermal | - | NTP ICE skin sensitization |
| 1.1 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 1.451 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 0.4 | % | EC3 | Dermal | Mouse | NTP ICE skin sensitization |
| 0.5 | % | EC3 | Dermal | Mouse | NTP ICE skin sensitization |
| 5.367 | uM | EC3 | Dermal | - | NTP ICE skin sensitization |
| 23RH73DZ65 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 94.78 | uM | IC50 | Dermal | - | NTP ICE skin sensitization |
| 138.2 | uM | IC50 | Dermal | - | NTP ICE skin sensitization |
| 13.1 | ratio | Imax | Dermal | - | NTP ICE skin sensitization |
| 13.53 | ratio | Imax | Dermal | - | NTP ICE skin sensitization |
| =951 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =1300 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| 2 | mg/kg bw/day | LOAEL | oral | rat | COSMOS DB |
| =0.5 | % | NOAEL | oral | rat | SCCS Opinion |
| =1.7 | mg/kg bw/d | NOAEL | oral | rat | SCCS Opinion |
| =5 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =5 | mg/kg bw/d | NOAEL | oral | rat | SCCS Opinion |
| =15 | mg/kg bw/d | NOAEL | oral | rat | SCCS Opinion |
| =70 | mg/kg bw/d | NOAEL | - | human | SCCS Opinion |
| =250 | mg/kg | NOAEL | oral | rat | SCCS Opinion |
| =0.004 | mg/kg bw/day | RfD | oral | Human | ToxValDB RSL |
| =0.04 | mg/kg bw/day | RfD | oral | Human | ToxValDB RSL |
| 250 | mg/kg | developmental toxicity | oral | rat | Regulatory source |
| 0.5 | % | repeated dose toxicity | oral | rat | Regulatory source |
| 1.7 | mg/kg bw/d | repeated dose toxicity | oral | rat | Regulatory source |
| 5 | mg/kg bw/d | repeated dose toxicity | oral | rat | Regulatory source |
| 15 | mg/kg bw/d | repeated dose toxicity | oral | rat | Regulatory source |
Showing 36 of 36 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-aminophenol | 202-431-1 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
EU Scientific Committee opinions tied to the matched substance.
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1398/10 | 22 June 2010 | safe | 1.5% | strong sensitiser; MoS adequate |
| SCCS/1291/10 | 2010-06-22 | Based on the submitted data, no final conclusion on the safety of o-aminophenol can be drawn. | - | Insufficient/inadequate physico-chemical data; inadequate skin sensitisation information; dermal absorption studies had shortcomings; mutagenic potential cannot be excluded (classified mutagen category 3). Requires complete physico-chemical set, skin sensitisation study, dermal absorption study, and gene mutation + chromosomal aberration/micronucleus tests. |
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
2-Aminophenol (CAS 95-55-6) is classified under EU CLP Annex VI as Muta. 2; Acute Tox. 4 *; Acute Tox. 4 * with signal word Warning. Hazard statements: H341; H332; H302. Source: EU CLP Annex VI (ECHA).
2-Aminophenol has 36 NOAEL studies in the database. The lowest reported value is 0.004 mg/kg bw/day via oral in Human. Source: ToxValDB RSL.
2-Aminophenol appears on 4 regulatory/inventory lists including Canada; pharmaceutical, detected; Europe; Personal care - hair coloring - hair color - professional, detected; Europe; Personal care - hair coloring, and 1 more. Source: EPA CPDat.
Yes, 2-Aminophenol is also indexed as a cosmetic ingredient under the name O-Aminophenol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
2-Aminophenol is classified GHS CMR hazard (H341, H332, H302) in the chemicals database but is restricted in EU cosmetics at max 2.0%.
2-Aminophenol also appears in cosmetics, pharmaceutical databases.