Also known as: Oxirane, phenyl-, 5-17-01-00577, Benzene, (1,2-epoxyethyl)-, BRN 0108582, EINECS 202-476-7 (+11 more)
CAS 96-09-3
Styrene oxide (CAS 96-09-3) is a chemical substance with GHS signal word Danger; key hazard signal: H350; H312; H319. Key regulatory status: California Proposition 65, REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, CA Prop 65, ILO ICSC, OSHA, EPA TRI.
Styrene oxide is prohibited in EU cosmetics but has active industrial GHS classifications (H350, H312, H319).
CAS, identifiers, formula, and alternate names for the matched substance record.
Carcinogenic hazard classification from IARC monograph evaluations.
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 2A | Probably carcinogenic | 2018 | Sup 7, 60, 121 |
California OEHHA listing status and toxicity category.
| Chemical | Toxicity Type | Cancer | Developmental | Listed |
|---|---|---|---|---|
| - | cancer | Yes | No | - |
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Carc. 1B; Acute Tox. 4 *; Eye Irrit. 2 | H350; H312; H319 | GHS08; GHS07 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Combustible liquid Harmful if swallowed Causes skin irritation Causes eye irritation Suspected of causing genetic defects May cause cancer |
| Short-term Effects | The substance is irritating to the eyes and skin. The substance may cause effects on the central nervous system. Exposure could cause lowering of consciousness. |
| Long-term Effects | This substance is probably carcinogenic to humans. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation, through the skin and by ingestion. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| ACGIH | TWA | 1 ppm (4.9 mg/m³) [2020] | 1 | 4.9 | N |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| banned; Europe; Personal care | European Commission | CosIng |
| IFRA Transparency | IFRA | IFRA |
| Cons electronics mech appliances and machinery; Europe | Danish Environmental Protection Agency | Danish EPA |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| OEHHA Proposition 65 (3/2019) | STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY | OEHHA Proposition 65 List |
| OEHHA Proposition 65 (1/2023) | California Office of Environmental Health Hazard Assessment | OEHHA Proposition 65 List |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| SQE4 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| SQE4 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| SQE4 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| SQE4 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| SQEcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| SQEcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| SQEcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| SQEcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| 9QH06NGT6O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9QH06NGT6O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9QH06NGT6O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9QH06NGT6O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2A | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2 | unitless | IARC group | - | - | NTP_ICE_cancer |
| =2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =3000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =4290 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =26 | mg/kg bw/day | LOEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =60 | mg/kg bw/day | LOEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =77 | mg/kg bw/day | LOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =180 | mg/kg bw/day | LOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| >=50 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =128 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =300 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| >=375 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
Showing 26 of 26 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | (epoxyethyl)benzene | 202-476-7 | ECHA overview → |
TRI hazard and reporting flags for the matched chemical.
| Chemical | Category | Flags |
|---|---|---|
| Styrene oxide | - | - |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Styrene oxide (CAS 96-09-3) is classified under EU CLP Annex VI as Carc. 1B; Acute Tox. 4 *; Eye Irrit. 2 with signal word Danger. Hazard statements: H350; H312; H319. Source: EU CLP Annex VI (ECHA).
Styrene oxide has 26 NOAEL studies in the database. The lowest reported value is 4 ug/day. Source: California Proposition 65.
Styrene oxide appears on 6 regulatory/inventory lists including banned; Europe; Personal care, IFRA Transparency, Cons electronics mech appliances and machinery; Europe, and 3 more. Source: EPA CPDat.
Styrene oxide is classified by IARC as Group 2A — probably carcinogenic to humans (evaluated 2018). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Yes, Styrene oxide is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.
Occupational exposure limits for Styrene oxide are set by ACGIH. 1 limit value from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Yes, Styrene oxide is also indexed as a cosmetic ingredient under the name Styrene Oxide. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, California Proposition 65, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Styrene oxide is prohibited in EU cosmetics but has active industrial GHS classifications (H350, H312, H319).
Styrene oxide also appears in cosmetics, pharmaceutical databases.