Also known as: 2,2'-Methylene-bis (4-chlorophenol), Anthiphen, Antifen, Antiphen, Bis(chlorohydroxyphenyl)methane (+15 more)
CAS 97-23-4
Dichlorophen (CAS 97-23-4) is a chemical substance with GHS signal word Warning; key hazard signal: H302; H319; H400; H410. Key regulatory status: California Proposition 65, 13 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, CA Prop 65, EPA TRI.
Dichlorophen is prohibited in EU cosmetics at max 0.5% but has active industrial GHS classifications (H302, H319, H400, H410).
CAS, identifiers, formula, and alternate names for the matched substance record.
California OEHHA listing status and toxicity category.
| Chemical | Toxicity Type | Cancer | Developmental | Listed |
|---|---|---|---|---|
| - | developmental | No | Yes | - |
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 4 *; Eye Irrit. 2; Aquatic Acute 1; Aquatic Chronic 1 | H302; H319; H400; H410 | GHS07; GHS09 | Warning |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
| active_ingredient; Australia | Australian Pesticides and Veterinary Medicines Authority | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| Europe; Personal care; restricted | European Commission | CosIng |
| Europe; nondetect; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| Canada; pharmaceutical | DrugBank | DrugBank |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| OEHHA Proposition 65 (3/2019) | STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY | OEHHA Proposition 65 List |
| OEHHA Proposition 65 (1/2023) | California Office of Environmental Health Hazard Assessment | OEHHA Proposition 65 List |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 1 | mg/kg/day | - | dermal | rabbit | Regulatory source |
| 25 | mg/kg/day | - | dermal | rabbit | Regulatory source |
| 15.48 | uM | AC50 | - | - | NTP ICE endocrine |
| 17.2 | uM | AC50 | - | - | NTP ICE endocrine |
| 14.85 | uM | ACC | - | - | NTP ICE endocrine |
| 16.02 | uM | ACC | - | - | NTP ICE endocrine |
| ABdevelopmental | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| 13.2 | uL/min/10^6 cells | Clint | - | Human | NTP ICE adme parameters |
| 37.5 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 110 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 5 | % | Concentration, one positive response | Dermal | Human | NTP ICE skin sensitization |
| 20 | % | Concentration, one positive response | Dermal | Human | NTP ICE skin sensitization |
| T1J0JOU64O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.0045 | fraction | Fu | - | Human | NTP ICE adme parameters |
| 0 | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 0.6667 | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 0.9091 | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 3488 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| 5625 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| 1.395e+4 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| 4.219e+4 | ug/cm2 | Induction dose per skin area, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 7.673e+4 | ug/cm2 | Induction dose per skin area, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| =1506 | mg/kg bw | LD50 | oral | Rat (Male) | NTP ICE acute oral |
| =1683 | mg/kg bw | LD50 | oral | Rat (Female) | NTP ICE acute oral |
| 0 | unitless | Model Score | - | - | NTP ICE endocrine |
| 0.0058 | unitless | Model Score | - | - | NTP ICE endocrine |
| 0.0643 | unitless | Model Score | - | - | NTP ICE endocrine |
| 0.337 | unitless | Model Score | - | - | NTP ICE endocrine |
| =1 | mg/kg/day | NOAEL | dermal | rabbit | CIR Safety Assessment |
| =25 | mg/kg/day | NOAEL | dermal | rabbit | CIR Safety Assessment |
| =30 | mg/kg/day | NOAEL | - | rat | CIR Safety Assessment |
| =75 | mg/kg/day | NOAEL | - | rat | CIR Safety Assessment |
| <100 | mg/kg/day | NOAEL | oral | rat | CIR Safety Assessment |
| =120 | mg/kg/day | NOAEL | oral | rat | CIR Safety Assessment |
| =240 | mg/kg/day | NOAEL | oral | rat | CIR Safety Assessment |
| >900 | mg/kg/day | NOAEL | oral | rat | CIR Safety Assessment |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
| 30 | mg/kg/day | developmental toxicity | - | rat | Regulatory source |
| 75 | mg/kg/day | developmental toxicity | - | rat | Regulatory source |
| 75 | mg/kg/day | developmental toxicity | dermal | rat | Regulatory source |
| <100 | mg/kg/day | developmental toxicity | oral | rat | Regulatory source |
| >100 | mg/kg/day | developmental toxicity | - | rat | Regulatory source |
| >900 | mg/kg/day | developmental toxicity | oral | rat | Regulatory source |
| 120 | mg/kg/day | oral toxicity | oral | rat | Regulatory source |
| 240 | mg/kg/day | oral toxicity | oral | rat | Regulatory source |
| 120 | mg/kg/day | repeated dose toxicity | - | rat | Regulatory source |
Showing 46 of 46 studies
TRI hazard and reporting flags for the matched chemical.
| Chemical | Category | Flags |
|---|---|---|
| Dichlorophene | - | - |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Dichlorophen (CAS 97-23-4) is classified under EU CLP Annex VI as Acute Tox. 4 *; Eye Irrit. 2; Aquatic Acute 1; Aquatic Chronic 1 with signal word Warning. Hazard statements: H302; H319; H400; H410. Source: EU CLP Annex VI (ECHA).
Dichlorophen has 46 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP ICE skin sensitization.
Dichlorophen appears on 11 regulatory/inventory lists including Indirect additives food contact (10/2018), active_ingredient; Europe; Pesticides, active_ingredient; Australia, and 8 more. Source: EPA CPDat.
Yes, Dichlorophen is listed under California Proposition 65 for developmental. Source: California OEHHA Proposition 65.
Yes, Dichlorophen is also indexed as a cosmetic ingredient under the name Dichlorophene. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, California Proposition 65, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Dichlorophen is prohibited in EU cosmetics at max 0.5% but has active industrial GHS classifications (H302, H319, H400, H410).
Dichlorophen also appears in cosmetics, pharmaceutical databases.