What is the NOAEL for Niacinamide?
Niacinamide has 14 NOAEL studies in the database. The lowest reported value is 43.75 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Niacinamide
Also known as: Nicotinamide, 3-Pyridinecarboxamide, Nam, EINECS 202-713-4, Pyridine, 3-carbamoyl- (+15 more)
CAS 98-92-0
Niacinamide (CAS 98-92-0) is a chemical substance. Key regulatory status: REACH registered, 9 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
SOURCE
noael studies public
NOAEL studies
14
SOURCE
chemical inventory jurisdictions
Regulatory lists
9
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Niacinamide
CAS Number
98-92-0
DTXSID
DTXSID2020929
Molecular Formula
C6H6N2O
InChI Key
DFPAKSUCGFBDDF-UHFFFAOYSA-N
Monoisotopic Mass
122.048013
Synonyms
Nicotinamide3-PyridinecarboxamideNamEINECS 202-713-4Pyridine, 3-carbamoyl-NicotinsaureamidUNII-25X51I8RD4Acid amideAmid kyseliny nikotinoveAmide PPAmixicotynAmnicotin
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| GHS Signal Word | WARNING |
| GHS Hazard Statements | Causes eye irritation |
| Short-term Effects | The substance is irritating to the eyes. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
36 records
HumectantSoftener and conditionerFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
9 records
| List | Keyword | Source |
|---|---|---|
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
| Europe; supplements | EU | CPCat |
| Europe; food_additive; supplements | EU | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 14 of 14 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =43.75 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 25X51I8RD4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 25X51I8RD4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 25X51I8RD4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 25X51I8RD4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =3500 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =5500 | mg/kg bw | LD50 | oral | Rat (Male/Female) | NTP_ICE_acute_oral |
| <7100 | mg/kg bw | LD50 | oral | Rat (Male/Female) | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =215 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HESS |
| 400 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 600 | mg/kg bw/day | NOAEL | oral | rabbit | COSMOS_DB |
| 800 | mg/kg bw/day | NOAEL | oral | guinea pig | COSMOS_DB |
| 1000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
Showing 14 of 14 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Nicotinamide | 202-713-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
active
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
NIACINAMIDE
ChEMBL Phase
4
Adverse Events
3772
Bioactivity
18
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Niacinamide?
Niacinamide appears on 7 regulatory/inventory lists including food_additive; Substances Added to Food (formerly EAFUS) (2/2019), Canada; consumer_product; Substances in Products - Canada (4/2014), inert_ingredient; non_food_use; Pesticides, and 4 more. Source: EPA CPDat.
Is Niacinamide used in cosmetics?
Yes, Niacinamide is also indexed as a cosmetic ingredient under the name Niacinamide. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Niacinamide come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Niacinamide used outside industrial chemicals?
Niacinamide also appears in cosmetics, pharmaceutical, food safety, cannabis databases.