What is the NOAEL for (-)-Epigallocatechin gallate?
(-)-Epigallocatechin gallate has 7 NOAEL studies in the database. The lowest reported value is 135 uL/min/10^6 cells in Human. Source: NTP ICE adme parameters.
NOAEL Data
REACH Registered
Cosmetic Ingredient
(-)-Epigallocatechin gallate
Also known as: EGCG, (-)-Epigallocatechin-3-o-gallate, (-)-Epigallocatechol gallate, Tea catechin, Teavigo (+7 more)
CAS 989-51-5
(-)-Epigallocatechin gallate (CAS 989-51-5) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
View cosmetic safety profile for EGCG (Epigallocatechin Gallate) →
SOURCE
NOAEL studies
NOAEL studies
7
SOURCE
Chemical inventory jurisdictions
Regulatory lists
1
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
18 fields
Name
(-)-Epigallocatechin gallate
CAS Number
989-51-5
DTXSID
DTXSID1029889
Molecular Formula
C22H18O11
InChI Key
WMBWREPUVVBILR-WIYYLYMNSA-N
Monoisotopic Mass
458.084911
Synonyms
EGCG(-)-Epigallocatechin-3-o-gallate(-)-Epigallocatechol gallateTea catechinTeavigoNVP-XAA 723L-Epigallocatechin gallateEpigallocatechin-3-monogallateUNII-BQM438CTELEpigallocatechin 3-gallate[(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate(-)-epigallocatechin 3-gallate
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Antioxidant
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 135 | uL/min/10^6 cells | Clint | - | Human | NTP ICE adme parameters |
| BQM438CTEL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| BQM438CTEL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| BQM438CTEL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| BQM438CTEL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =60 | mg/org | LOEL | oral | Rat | ToxValDB ECOTOX |
| =50 | mg/kg bw/day | NOAEL | oral | Dog | ECHA |
Showing 7 of 7 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate | 479-560-7 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
sunscreen
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
EPIGALOCATECHIN GALLATE
ChEMBL Phase
3
Adverse Events
0
Bioactivity
10
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include (-)-Epigallocatechin gallate?
(-)-Epigallocatechin gallate appears on 1 regulatory/inventory list including Canada; pharmaceutical. Source: EPA CPDat.
Is (-)-Epigallocatechin gallate used in cosmetics?
Yes, (-)-Epigallocatechin gallate is also indexed as a cosmetic ingredient under the name EGCG (Epigallocatechin Gallate). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for (-)-Epigallocatechin gallate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is (-)-Epigallocatechin gallate used outside industrial chemicals?
(-)-Epigallocatechin gallate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.