What is the NOAEL for Methylparaben?
Methylparaben has 100 NOAEL studies in the database. The lowest reported value is 0 % via Dermal. Source: NTP ICE skin sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Methylparaben
Also known as: Methyl paraben (Benzoic acid, 4-hydroxy-, methyl ester), Aseptoform, BRN 0509801, Caswell No. 573PP, EINECS 202-785-7 (+15 more)
CAS 99-76-3
Methylparaben (CAS 99-76-3) is a chemical substance. Key regulatory status: REACH registered, 49 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.
SOURCE
NOAEL studies
NOAEL studies
100
SOURCE
Chemical inventory jurisdictions
Regulatory lists
49
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Methylparaben
CAS Number
99-76-3
DTXSID
DTXSID4022529
Molecular Formula
C8H8O3
InChI Key
LXCFILQKKLGQFO-UHFFFAOYSA-N
Monoisotopic Mass
152.047344
Synonyms
Methyl paraben (Benzoic acid, 4-hydroxy-, methyl ester)AseptoformBRN 0509801Caswell No. 573PPEINECS 202-785-7EPA Pesticide Chemical Code 061201FEMA Number 2710Methylester kyseliny p-hydroxybenzooveUNII-A2I8C7HI9TE 218E218FEMA No. 2710
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
PreservativeFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
49 records
| List | Keyword | Source |
|---|---|---|
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| Personal care; Southeast Asia | Asean | ASEAN Cosmetics |
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
| inert_ingredient; Pesticides | EPA | CPCat |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| children; WA Children's Safe Product Act (4/2020) | State of Washington Department of Ecology | State of Washington |
| children | Vermont Department of Health | State of Vermont |
| children | Maine Department of Environmental Protection | State of Maine |
| detected; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| detected; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| detected; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| detected; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| detected; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| detected; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| detected; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| children | Oregon Health Authority | State of Oregon |
| artificial_sweat; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; Europe | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; Europe | Danish Environmental Protection Agency | Danish EPA |
| detected; Personal care; Southeast Asia | Asean | ASEAN Cosmetics |
| Europe; Personal care - body hygiene - hand soap | Danish Environmental Protection Agency | Danish EPA |
| Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bath salts | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - general moisturizing - hand/body lotion | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - body hygiene - body wash | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - hair styling and care - shampoo | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bubble bath | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - dental care - toothpaste | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 100 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 0.1 | % | - | oral | rat | Regulatory source |
| 0.1 | % | - | oral | rat | Regulatory source |
| 0.105 | mg/kg bw/day | - | - | rat | Regulatory source |
| 0.105 | mg/kg bw/day | - | - | rat | Regulatory source |
| 24 | - | - | - | - | Regulatory source |
| 24 | - | - | - | - | Regulatory source |
| 67.8 | mg/kg/d | - | - | rat | Regulatory source |
| 250 | mg/kg bw/day | - | - | rat | Regulatory source |
| 250 | mg/kg bw/day | - | - | rat | Regulatory source |
| 250 | mg/kg bw/day | - | - | rat | Regulatory source |
| 250 | mg/kg bw/day | - | - | rat | Regulatory source |
| 1000 | mg/kg bw/day | - | - | - | Regulatory source |
| 1000 | mg/kg bw/d | - | oral | rat | Regulatory source |
| 1000 | mg/kg/day | - | oral | rat | Regulatory source |
| 1000 | mg/kg bw/day | - | - | rat | Regulatory source |
| 1000 | mg/kg bw/day | - | - | rat | Regulatory source |
| 1000 | mg/kg bw/day | - | - | - | Regulatory source |
| 1000 | mg/kg bw | - | - | - | Regulatory source |
| 1000 | mg/kg bw/day | - | - | - | Regulatory source |
| 1000 | mg/kg bw/d | - | oral | rat | Regulatory source |
| 1000 | mg/kg/day | - | oral | rat | Regulatory source |
| 1000 | mg/kg bw/day | - | - | rat | Regulatory source |
| 1000 | mg/kg bw/day | - | - | rat | Regulatory source |
| 1000 | mg/kg bw/day | - | - | - | Regulatory source |
| 1000 | mg/kg bw | - | - | - | Regulatory source |
| 64.1358560333104 | uM | AC50 | - | - | NTP ICE endocrine |
| 7800 | nM | AC50/EC50/IC50 | - | - | NTP ICE endocrine |
| 10200 | nM | AC50/EC50/IC50 | - | - | NTP ICE endocrine |
| 100000 | nM | AC50/EC50/IC50 | - | - | NTP ICE endocrine |
| 208000 | nM | AC50/EC50/IC50 | - | - | NTP ICE endocrine |
| 58.830885379248 | uM | ACC | - | - | NTP ICE endocrine |
| 52 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 86.2 | uL/min/10^6 cells | Clint | - | Rat | NTP ICE adme parameters |
| 107.5 | uL/min/10^6 cells | Clint | - | Human | NTP ICE adme parameters |
| 30.625 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 6.25 | % | Concentration, one positive response | Dermal | Human | NTP ICE skin sensitization |
| =176.3 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 3.6 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| - | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| <381.78 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 805.4 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| A2I8C7HI9T | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| A2I8C7HI9T | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| A2I8C7HI9T | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| A2I8C7HI9T | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.07056 | fraction | Fu | - | Human | NTP ICE adme parameters |
| 0.174 | fraction | Fu | - | Rat | NTP ICE adme parameters |
| 26900 | nM | IC01 | - | - | NTP ICE endocrine |
| >950 | uM | IC50 | Dermal | - | NTP ICE skin sensitization |
| >2000 | uM | IC50 | Dermal | - | NTP ICE skin sensitization |
Showing 50 of 100 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Methyl 4-hydroxybenzoate | 202-785-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
SCCS Opinion
1 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1652/23 | 14 December 2023 | Safe — safe as preservative at current EU-authorised concentrations | 0.4% as individual ester; 0.8% in mixtures of esters | Endocrine disruption potential evaluated; estrogenic potency very low; no additional restrictions required beyond existing Annex V limits |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
0.4% (as acid); mixture cap all parabens 0.8%
Category
preservative
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
METHYLPARABEN
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
12
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
E218 — ADI: 10 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Methylparaben?
Methylparaben appears on 31 regulatory/inventory lists including Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe, inert_ingredient; non_food_use; Pesticides, active_ingredient; Europe; Pesticides, and 28 more. Source: EPA CPDat.
Is Methylparaben used in cosmetics?
Yes, Methylparaben is also indexed as a cosmetic ingredient under the name Methylparaben. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Methylparaben come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Methylparaben used outside industrial chemicals?
Methylparaben also appears in cosmetics, pharmaceutical, food safety, cannabis databases.