What is the NOAEL for N,N-Dimethyl-p-phenylenediamine?
N,N-Dimethyl-p-phenylenediamine has 7 NOAEL studies in the database. The lowest reported value is 7GZH2FMK7X UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
N,N-Dimethyl-p-phenylenediamine
Also known as: NSC 1493, p-Dimethylaminophenylamine, 4-(Dimethylamino)phenylamine, Dimethyl-para-phenylenediamine, EINECS 202-807-5 (+7 more)
CAS 99-98-9
N,N-Dimethyl-p-phenylenediamine (CAS 99-98-9) is a chemical substance. Key regulatory status: 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
View cosmetic safety profile for N,N-DIMETHYL-P-PHENYLENEDIAMINE →
Cross-Vertical Regulatory Divergence
N,N-Dimethyl-p-phenylenediamine is classified GHS Danger (H301, H311, H331, H300, H310) in the chemicals database but is restricted in EU cosmetics at max II/1312.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
7
SOURCE
Chemical inventory jurisdictions
Regulatory lists
2
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
18 fields
Name
N,N-Dimethyl-p-phenylenediamine
CAS Number
99-98-9
DTXSID
DTXSID6025149
Molecular Formula
C8H12N2
InChI Key
BZORFPDSXLZWJF-UHFFFAOYSA-N
Monoisotopic Mass
136.100048
Synonyms
NSC 1493p-Dimethylaminophenylamine4-(Dimethylamino)phenylamineDimethyl-para-phenylenediamineEINECS 202-807-5N,N-Dimethyl-p-fenylendiaminUNII-7GZH2FMK7XDimethyl-4-phenylenediamineDMPDDMPPDA202-807-5EC No.: 202-807-5
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| - | Mutation Research/Reviews in Genetic Toxicology | Published Articles |
| banned; Europe; Personal care | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 7GZH2FMK7X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7GZH2FMK7X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7GZH2FMK7X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7GZH2FMK7X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =50 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =67 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =171 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
Showing 7 of 7 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
II/1312
Category
Hair Dyes
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
CHEMBL36296
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What regulatory lists include N,N-Dimethyl-p-phenylenediamine?
N,N-Dimethyl-p-phenylenediamine appears on 1 regulatory/inventory list including banned; Europe; Personal care. Source: EPA CPDat.
Is N,N-Dimethyl-p-phenylenediamine used in cosmetics?
Yes, N,N-Dimethyl-p-phenylenediamine is also indexed as a cosmetic ingredient under the name N,N-DIMETHYL-P-PHENYLENEDIAMINE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for N,N-Dimethyl-p-phenylenediamine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does N,N-Dimethyl-p-phenylenediamine have different safety status in cosmetics vs industrial chemicals?
N,N-Dimethyl-p-phenylenediamine is classified GHS Danger (H301, H311, H331, H300, H310) in the chemicals database but is restricted in EU cosmetics at max II/1312.
Is N,N-Dimethyl-p-phenylenediamine used outside industrial chemicals?
N,N-Dimethyl-p-phenylenediamine also appears in cosmetics, pharmaceutical databases.