NOAEL Studies
Cosmetic Ingredient
1-Naphthol NOAEL Studies
INCI: 1-NAPHTHOL
CAS: 90-15-3
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS DB 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | LOAEL | 100 | mg/kg bw/day | rat | oral | 7-17 Gestation day | Developmental | SCCP; Oral (Gavage) Developmental Toxicity Study of RE-1141.02 in Rats, P&G Study # BTS 0704/02 (Protocol 916-020), May 2003 |
| COSMOS DB | NOAEL | 20 | mg/kg bw/day | rat | oral | 7-17 Gestation day | Developmental | SCCP; Oral (Gavage) Developmental Toxicity Study of RE-1141.02 in Rats, P&G Study # BTS 0704/02 (Protocol 916-020), May 2003 |
NTP ICE acute inhalation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | LC50 | >0.42 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3345; Record_ID=acute_inhalation_2838; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6021793; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=0.42; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021793 |
NTP ICE acute oral 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =2380 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_11282; row=10069; data_type=In Vivo; mixture=Chemical; chemical_name=1-Naphthol; preferred_name=1-Naphthol; dtxsid=DTXSID6021793; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021793; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =1870 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_11280; row=10070; data_type=In Vivo; mixture=Chemical; chemical_name=1-Naphthol; preferred_name=1-Naphthol; dtxsid=DTXSID6021793; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021793; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =2590 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_11284; row=10071; data_type=In Vivo; mixture=Chemical; chemical_name=1-Naphthol; preferred_name=1-Naphthol; dtxsid=DTXSID6021793; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021793; source_file=acute_oral.xlsx |
NTP ICE adme parameters 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE adme parameters | Clint | 0 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=2376; Record_ID=adme_parameters_800; Data_Type=Measured; DTXSID=DTXSID6021793; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=0.0; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021793 |
| NTP ICE adme parameters | Fu | 0.0682 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=2377; Record_ID=adme_parameters_800; Data_Type=Measured; DTXSID=DTXSID6021793; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.0682; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021793 |
NTP ICE endocrine 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | AC50 | 41.6250028012423 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=1240; RecordID=ERPathway2016_328; DatasetName=ERPathway2016; DTXSID=DTXSID6021793; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=41.6250028012423; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021793 |
| NTP ICE endocrine | ACC | 26.3047473279735 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=1241; RecordID=ERPathway2016_328; DatasetName=ERPathway2016; DTXSID=DTXSID6021793; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=26.3047473279735; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021793 |
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=1236; RecordID=ARPathway2016_1700; DatasetName=ARPathway2016; DTXSID=DTXSID6021793; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021793 |
| NTP ICE endocrine | Model Score | 0.0232 | unitless | - | - | - | ERPathway2016; ER Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=1242; RecordID=ERPathway2016_328; DatasetName=ERPathway2016; DTXSID=DTXSID6021793; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.0232; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021793 |
NTP ICE skin sensitization 16 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | CD54, EC200 | 12.7 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3589; Record_ID=skin_sensitization_invitro_824; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID6021793; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=12.7; Reported_Response_Unit=ug/mL; Response=12.7; Response_Unit=ug/mL; Reference=Ashikaga et al. 2010; 20822320; 10.1177/026119291003800403|Nukada et al. 2012; 22796097; 10.1016/j.tiv.2012.07.001|Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021793 |
| NTP ICE skin sensitization | CD86, EC150 | 18.3 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3592; Record_ID=skin_sensitization_invitro_824; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID6021793; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=18.3; Reported_Response_Unit=ug/mL; Response=18.3; Response_Unit=ug/mL; Reference=Ashikaga et al. 2010; 20822320; 10.1177/026119291003800403|Nukada et al. 2012; 22796097; 10.1016/j.tiv.2012.07.001|Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021793 |
| NTP ICE skin sensitization | CD86, EC150 | 1.4 | ug/mL | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; U-SENS | sheet=Data_invitro; excel_row=8271; Record_ID=skin_sensitization_invitro_2294; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID6021793; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=9.710556068; Reported_Response_Unit=uM; Conversion_Factor_Value=144.173; Conversion_Factor_Source=EPA Dashboard; Converted_Response=1.4; Converted_Response_Unit=ug/mL; Response=1.4; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021793 |
| NTP ICE skin sensitization | CV75 | 57.2 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3595; Record_ID=skin_sensitization_invitro_824; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID6021793; Assay=h-CLAT; Endpoint=CV75; Reported_Response=57.2; Reported_Response_Unit=ug/mL; Response=57.2; Response_Unit=ug/mL; Reference=Ashikaga et al. 2010; 20822320; 10.1177/026119291003800403|Nukada et al. 2012; 22796097; 10.1016/j.tiv.2012.07.001|Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021793 |
| NTP ICE skin sensitization | Depletion Cys | 21.8 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=269; Record_ID=skin_sensitization_invitro_90; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6021793; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=21.8; Reported_Response_Unit=%; Response=21.8; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021793 |
| NTP ICE skin sensitization | Depletion Cys | 68.2 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1440; Record_ID=skin_sensitization_invitro_384; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6021793; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=68.2; Reported_Response_Unit=%; Response=68.2; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021793 |
| NTP ICE skin sensitization | Depletion Lys | 17.4 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=267; Record_ID=skin_sensitization_invitro_90; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6021793; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=17.399999999999999; Reported_Response_Unit=%; Response=17.4; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021793 |
| NTP ICE skin sensitization | Depletion Lys | 12.4 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1439; Record_ID=skin_sensitization_invitro_384; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6021793; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=12.4; Reported_Response_Unit=%; Response=12.4; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021793 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 20 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=272; Record_ID=skin_sensitization_invitro_90; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6021793; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=20; Reported_Response_Unit=%; Response=20; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021793 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 40.3 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1441; Record_ID=skin_sensitization_invitro_384; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6021793; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=40.299999999999997; Reported_Response_Unit=%; Response=40.3; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021793 |
| NTP ICE skin sensitization | EC1.5 | 129.6 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; KeratinoSens | sheet=Data_invitro; excel_row=6895; Record_ID=skin_sensitization_invitro_1633; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID6021793; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=129.6176795; Reported_Response_Unit=uM; Response=129.6; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021793 |
| NTP ICE skin sensitization | EC1.5 | 129.62 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6897; Record_ID=skin_sensitization_invitro_1632; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6021793; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=129.62; Reported_Response_Unit=uM; Response=129.62; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021793 |
| NTP ICE skin sensitization | EC3 | 1.3 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13472; Record_ID=skin_sensitization_invivo_3641; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID6021793; Assay=LLNA; Endpoint=EC3; Response=1.3; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021793 |
| NTP ICE skin sensitization | IC50 | 541 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6898; Record_ID=skin_sensitization_invitro_1632; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6021793; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=541; Reported_Response_Unit=uM; Response=541; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021793 |
| NTP ICE skin sensitization | Imax | 1.78 | ratio | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; KeratinoSens | sheet=Data_invitro; excel_row=6902; Record_ID=skin_sensitization_invitro_1633; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID6021793; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.780006546; Reported_Response_Unit=Unitless; Response=1.78; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021793 |
| NTP ICE skin sensitization | Imax | 1.89 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6904; Record_ID=skin_sensitization_invitro_1632; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6021793; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.89; Reported_Response_Unit=Unitless; Response=1.89; Response_Unit=Ratio; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021793 |
SCCNFP Opinion 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCNFP Opinion | NOAEL | =20 | mg/kg bw/day | rat | - | 30-day | developmental toxicity | p.2 |
| SCCNFP Opinion | NOAEL | =20 | mg/kg | rat | oral | 90 day | dermal absorption | p.11 |
| SCCNFP Opinion | NOAEL | =100 | mg/kg bw/day | rat | - | 30-day | developmental toxicity | p.2 |
SCCS Opinion 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCS Opinion | NOAEL | =20 | mg/kg bw | - | dermal | 90 day | NOAEL study | p.5 |
| SCCS Opinion | NOAEL | =20 | mg/kg bw/day | human | - | developmental | developmental toxicity | p.23 |
| SCCS Opinion | NOAEL | =65 | mg/kg bw/day | rat | - | developmental | developmental toxicity | p.24 |
| SCCS Opinion | NOAEL | =100 | mg/kg bw/day | rat | oral | Sub-chronic | repeated dose toxicity | p.14 |
| SCCS Opinion | NOAEL | =130 | mg/kg bw/day | rat | - | 90-days | NOAEL study | p.15 |
| SCCS Opinion | NOAEL | =130 | mg/kg bw | rat | - | developmental | developmental toxicity | p.24 |
| SCCS Opinion | NOAEL | =400 | mg/kg bw/day | human | - | developmental | developmental toxicity | p.23 |
ECHA 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LEL | =1000 | mg/kg bw/day | Rat | oral | - | acute | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22250/7/3/2?documentUUID=20e738e1-012b-4bbe-86fe-dbfa9c4ef8c2; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID:15809458:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_042ad43296d6032eedf9bf07a19d17c0 |
| ECHA | LOAEL | ~600 | mg/kg bw/day | Rat | oral | short-term; 15 days | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cc0de4b0a7c65d228cb0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22250/7/6/2?documentUUID=20e738e1-012b-4bbe-86fe-dbfa9c4ef8c2; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical signs|gross pathology|mortality; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|gross pathology|mortality/survival; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15829977_15850929:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_81c7bebef19c2f7ab4bba6645fe896b3 |
| ECHA | LOAEL | ~400 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf50e4b0a7c65d1cd676; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22250/7/6/2?documentUUID=20e738e1-012b-4bbe-86fe-dbfa9c4ef8c2; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=stomach: clinical signs|histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15830132_15848825:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9ebbe43756423ec78f13560395c7a31c |
| ECHA | NOAEL | ~400 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac86e4b0a7c65d1bf98b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22250/7/9/3?documentUUID=20e738e1-012b-4bbe-86fe-dbfa9c4ef8c2; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=fetus: changes in litter size and weights; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15825283:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1cc5c5eb035b3b70e54776b3d7ce4438 |
| ECHA | NOAEL | >200 | mg/kg bw/day | Mouse | oral | short-term; 30 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf50e4b0a7c65d1cd67f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22250/7/6/2?documentUUID=20e738e1-012b-4bbe-86fe-dbfa9c4ef8c2; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID:15848565:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_41bc418f4e7740fbf8212b46157f2a46 |
| ECHA | NOAEL | ~130 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf50e4b0a7c65d1cd676; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22250/7/6/2?documentUUID=20e738e1-012b-4bbe-86fe-dbfa9c4ef8c2; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15830132_15848825:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_bdf8a001f2bbb4a702a60dbd2e43bc65 |
| ECHA | NOAEL | ~100 | mg/kg bw/day | Mouse | oral | short-term; 30 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf50e4b0a7c65d1cd67f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22250/7/6/2?documentUUID=20e738e1-012b-4bbe-86fe-dbfa9c4ef8c2; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=gross pathology; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology; STUDY_GROUP=ECHA IUCLID:15849004:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_bc9568748a4880aeec0af6f435e476aa |
| ECHA | NOAEL | ~120 | mg/kg bw/day | Rat | oral | short-term; 15 days | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cc0de4b0a7c65d228cb0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22250/7/6/2?documentUUID=20e738e1-012b-4bbe-86fe-dbfa9c4ef8c2; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15829977_15850929:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_625502277c6a5c11aa0cdcc96524212f |
| ECHA | NOEL | ~20 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac86e4b0a7c65d1bf98b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22250/7/9/3?documentUUID=20e738e1-012b-4bbe-86fe-dbfa9c4ef8c2; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=maternal: clinical signs; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECHA IUCLID:15825284:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_39cf60adf86823f6d27ac94e4b2835fb |
ToxValDB ECOTOX 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =1 | mg/kg bw/day | Rat | oral | acute; 1 days | acute | LONG_REF=EPA/OTS Doc.#86-920000742:1534 p. Union Carbide Chemical and Plastics Co. Letter Submitting Multiple Enclosed Studies on Multiple Chemicals with Attachments 1991; TITLE=Letter Submitting Multiple Enclosed Studies on Multiple Chemicals with Attachments; AUTHOR=Union Carbide Chemical and Plastics Co.; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75195; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15604322_15604323:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5063000c3945917fde14e2480cceb5b1 |
| ToxValDB ECOTOX | NOEL | =1000 | mg/kg bw/day | Rat | oral | short-term; 7 days | short-term | LONG_REF=EPA/OTS Doc.#86-920000269S:264 p. EPA/OTS Letter to U.S.EPA Regarding Information on the Enclosed Health and Safety Studies on Alpha-Naphthol with Attachments (Sanitized) 1991; TITLE=Letter to U.S.EPA Regarding Information on the Enclosed Health and Safety Studies on Alpha-Naphthol with Attachments (Sanitized); AUTHOR=EPA/OTS; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=88959; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=Enzyme(s): Cholinesterase|Feeding behavior: Food consumption|Growth: Weight|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|neurotransmitter|other; STUDY_GROUP=ECOTOX:15594942:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=fd32395f366a21a734652199948d5ff7 |
| ToxValDB ECOTOX | NOEL | =1 | mg/kg bw/day | Rat | oral | short-term; 8 days | short-term | LONG_REF=EPA/OTS Doc.#86-920000742:1534 p. Union Carbide Chemical and Plastics Co. Letter Submitting Multiple Enclosed Studies on Multiple Chemicals with Attachments 1991; TITLE=Letter Submitting Multiple Enclosed Studies on Multiple Chemicals with Attachments; AUTHOR=Union Carbide Chemical and Plastics Co.; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75195; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=Enzyme(s): Acetylcholinesterase|Feeding behavior: Food consumption|Morphology: Organ weight in relationship to body weight|Mortality: Mortality; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption|mortality/survival|neurotransmitter|organ weight; STUDY_GROUP=ECOTOX:15599806:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3ce443b92c809ceef1a49df2938dc832 |
| ToxValDB ECOTOX | NOEL | =0.25 | mg/kg bw/day | Rat | oral | short-term; 30 days | short-term | LONG_REF=EPA/OTS Doc.#86-920000742:1534 p. Union Carbide Chemical and Plastics Co. Letter Submitting Multiple Enclosed Studies on Multiple Chemicals with Attachments 1991; TITLE=Letter Submitting Multiple Enclosed Studies on Multiple Chemicals with Attachments; AUTHOR=Union Carbide Chemical and Plastics Co.; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75195; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=Accumulation: Residue|Growth: Weight|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|organ weight|other; STUDY_GROUP=ECOTOX:15602317:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1e27943af08522beb9844c0d1fb71945 |
| ToxValDB ECOTOX | NOEL | =6500 | ppm | Rat | oral | short-term; 28 days | short-term | LONG_REF=EPA/OTS Doc.#86-920000514S:7 p. Industrial Bio-Test Laboratories Summary Results Concerning an Acute Oral LD50, Acute Eye Irritation, Primary Skin & Eye Irritation Indexes & 28-Day Subacute Feeding Studies with Cover Sheet & Letter (Sanitized) 1991; TITLE=Summary Results Concerning an Acute Oral LD50, Acute Eye Irritation, Primary Skin & Eye Irritation Indexes & 28-Day Subacute Feeding Studies with Cover Sheet & Letter (Sanitized); AUTHOR=Industrial Bio-Test Laboratories; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=88884; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15603242_15604212_15604213:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=9c60786f54249d47a11e33cbe559a3ad |
| ToxValDB ECOTOX | NOEL | =3250 | ppm | Rat | oral | short-term; 28 days | short-term | LONG_REF=EPA/OTS Doc.#86-920000514S:7 p. Industrial Bio-Test Laboratories Summary Results Concerning an Acute Oral LD50, Acute Eye Irritation, Primary Skin & Eye Irritation Indexes & 28-Day Subacute Feeding Studies with Cover Sheet & Letter (Sanitized) 1991; TITLE=Summary Results Concerning an Acute Oral LD50, Acute Eye Irritation, Primary Skin & Eye Irritation Indexes & 28-Day Subacute Feeding Studies with Cover Sheet & Letter (Sanitized); AUTHOR=Industrial Bio-Test Laboratories; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=88884; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15603242_15604212_15604213:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=706f9e0f827a575ae6b3b0cb6fe6a31e |
| ToxValDB ECOTOX | NOEL | =0.5 | mg/kg bw/day | Rat | oral | acute; 1 days | acute | LONG_REF=EPA/OTS Doc.#86-920000742:1534 p. Union Carbide Chemical and Plastics Co. Letter Submitting Multiple Enclosed Studies on Multiple Chemicals with Attachments 1991; TITLE=Letter Submitting Multiple Enclosed Studies on Multiple Chemicals with Attachments; AUTHOR=Union Carbide Chemical and Plastics Co.; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75195; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15604322_15604323:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2b2ccebf191efaf10d6f1001852ceae8 |
| ToxValDB ECOTOX | NOEL | =200 | mg/kg bw/day | Mouse | oral | subchronic; 31 days | subchronic | LONG_REF=- | Food Chem. Toxicol.27(4): 233-238 Poole,A., and P. Buckley 1-Naphthol-Single and Repeated Dose (30-Day) Oral Toxicity Studies in the Mouse 1989; TITLE=1-Naphthol-Single and Repeated Dose (30-Day) Oral Toxicity Studies in the Mouse; AUTHOR=Poole,A., and P. Buckley; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=53242; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Histology: Lesions|Biochemistry: ALT, ALP, GLDH, TP,ALB,BUN,CREA, GLU| Haematology: Hgh, RBC, Hct,Plt,WBC, Nuetro, Lymph, Mono, Eosin; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|hematology|nonneoplastic histopathology; STUDY_GROUP=ECOTOX:15613593:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=5493dfc01157ac5a42d8c4b3cb9bbfcb |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =4.58 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15633718:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_eb7952f73286b10e2f4f1c3bbfbe8cc8 |
Regulatory source 14 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | - | 20 | mg/kg | rat | oral | 90 day | - | p.11 |
| Regulatory source | dermal absorption | =20 | mg/kg | rat | oral | 90 day | dermal absorption | p.11 |
| Regulatory source | developmental toxicity | 20 | mg/kg bw/day | rat | - | 30-day | developmental toxicity | p.2 |
| Regulatory source | developmental toxicity | 100 | mg/kg bw/day | rat | - | 30-day | developmental toxicity | p.2 |
| Regulatory source | - | 20 | mg/kg bw | - | dermal | 90 day | - | p.5 |
| Regulatory source | - | 130 | mg/kg bw/day | rat | - | 90-days | - | p.15 |
| Regulatory source | - | 130 | mg/kg bw | rat | - | 90-days | - | p.15 |
| Regulatory source | dermal absorption | =20 | mg/kg bw | rat | oral | - | dermal absorption | p.24 |
| Regulatory source | developmental toxicity | 20 | mg/kg bw/day | human | - | developmental | developmental toxicity | p.23 |
| Regulatory source | developmental toxicity | 65 | mg/kg bw/day | rat | - | developmental | developmental toxicity | p.24 |
| Regulatory source | developmental toxicity | 130 | mg/kg bw | rat | - | developmental | developmental toxicity | p.24 |
| Regulatory source | developmental toxicity | 400 | mg/kg bw/day | human | - | developmental | developmental toxicity | p.23 |
| Regulatory source | developmental toxicity | 400 | mg/kg bw/day | rat | - | developmental | developmental toxicity | p.24 |
| Regulatory source | repeated dose toxicity | 100 | mg/kg bw/day | rat | oral | Sub-chronic | repeated dose toxicity | p.14 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 2A71EAQ389 | UNII | - | - | - | chemical | - |