NOAEL Studies Cosmetic Ingredient

2,7-Naphthalenediol NOAEL Studies

INCI: 2,7-NAPHTHALENEDIOL

CAS: 582-17-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 195 mg/kg bw/day rat oral 5-19 Gestation day Developmental SCCS; Patel, M.V. Prenatal developmental toxicity study of A 019 in rats. Jai Research Foundation, Valvada, India, internal study code: 4745. Archive code at Henkel KGaA, Düsseldorf, Report No. R 0500011
COSMOS DB NOAEL 65 mg/kg bw/day rat oral 5-19 Gestation day Developmental SCCS; Patel, M.V. Prenatal developmental toxicity study of A 019 in rats. Jai Research Foundation, Valvada, India, internal study code: 4745. Archive code at Henkel KGaA, Düsseldorf, Report No. R 0500011
SCCS Opinion 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =60 mg/kg/day rat oral 5 weeks NOAEL study p.15
SCCS Opinion NOAEL =70 mg/kg bw/day rat - 90 days NOAEL study p.16
SCCS Opinion NOAEL =65 mg/kg bw/day human - - NOAEL study p.22
SCCS Opinion NOAEL =585 mg/kg bw/day human - - NOAEL study p.22
SCCS Opinion NOAEL =0.06 mg/kg bw/d rat oral - dermal absorption p.22
SCCS Opinion NOAEL =65 mg/kg bw/d rat oral - dermal absorption p.22
SCCS Opinion NOAEL =0.04 mg/kg bw/d rat oral - dermal absorption p.22
Regulatory source 16 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 60 mg/kg/day rat oral 5 weeks - p.15
Regulatory source - 70 mg/kg bw/day rat - 90 days - p.16
Regulatory source - 60 mg/kg rat oral 11 week - p.21
Regulatory source - 65 mg/kg bw/day human - - - p.22
Regulatory source - 585 mg/kg bw/day human - - - p.22
Regulatory source - 60 mg/kg bw/day rat oral 5 weeks - p.14
Regulatory source - 60 mg/kg bw rat oral 11 week - p.20
Regulatory source dermal absorption 70 mg/kg bw/day rat dermal 90 day dermal absorption p.23
Regulatory source dermal absorption 65 mg/kg bw/day rat dermal 90 day dermal absorption p.23
Regulatory source dermal absorption =0.06 mg/kg bw/d rat oral - dermal absorption p.22
Regulatory source dermal absorption =65 mg/kg bw/d rat oral - dermal absorption p.22
Regulatory source dermal absorption =0.04 mg/kg bw/d rat oral - dermal absorption p.22
Regulatory source irritation 70 mg/kg bw/day rat oral 90 day irritation p.23
Regulatory source irritation 70 mg/kg bw/day rat dermal 90 day irritation p.23
Regulatory source irritation 70 mg/kg bw/day rat - 90 day irritation p.22
Regulatory source irritation 65 mg/kg bw/day rat - 90 day irritation p.22
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 0TO8E448UD UNII - - - chemical -