Moderate Cosmetic Ingredient

3-Hexyloxycarbonyl-4,4'-Diaminodiphenylamine HCl

INCI: 3-HEXYLOXYCARBONYL-4,4'-DIAMINODIPHENYLAMINE HCL

CAS Number
Not widely published in public databases — this is a specialty oxidative hair dye intermediate
Function
Hair dyeing (oxidative hair dye coupler/developer)
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status permitted
US Notes Hair dyes are exempt from FD&C premarket approval under the coal-tar hair dye exemption (21 USC §361(a)), but must carry the statutory caution/patch test warning

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
high
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Aromatic amine hair dye with potential mutagenicity/genotoxicity concern; cross-reactivity with p-phenylenediamine (PPD) class allergens; verify current EU Annex II/III status before formulation.

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Concern Level: High

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is 3-Hexyloxycarbonyl-4,4'-Diaminodiphenylamine HCl safe in cosmetics?

Aromatic amine hair dye with potential mutagenicity/genotoxicity concern; cross-reactivity with p-phenylenediamine (PPD) class allergens; verify current EU Annex II/III status before formulation. The EU classifies 3-Hexyloxycarbonyl-4,4'-Diaminodiphenylamine HCl as "prohibited". Safety rating: MODERATE.

Is 3-Hexyloxycarbonyl-4,4'-Diaminodiphenylamine HCl allowed in the EU?

3-Hexyloxycarbonyl-4,4'-Diaminodiphenylamine HCl EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does 3-Hexyloxycarbonyl-4,4'-Diaminodiphenylamine HCl do in cosmetics?

3-Hexyloxycarbonyl-4,4'-Diaminodiphenylamine HCl functions as: Hair dyeing (oxidative hair dye coupler/developer). It is classified as a cosmetic ingredient in our database. CAS number: Not widely published in public databases — this is a specialty oxidative hair dye intermediate.

What is the Margin of Safety for 3-Hexyloxycarbonyl-4,4'-Diaminodiphenylamine HCl?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check 3-Hexyloxycarbonyl-4,4'-Diaminodiphenylamine HCl compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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