5-Methyl-2-Hepten-4-One

INCI: TRANS-5-METHYL-2-HEPTEN-4-ONE

CAS Number
81925-81-7 (trans-isomer: 102322-83-8)
Function
Perfuming
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted — no FDA restriction; RIFM-assessed

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Identified skin sensitizer with NESIL of 250 µg/cm²; α,β-unsaturated carbonyl structure presents Michael-addition reactivity risk with skin proteins; not phototoxic, not PBT, with PEC/PNEC ratio below 1.

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Concern Level: High

Regulatory Flags

potential-allergen fragrance-component jecfa_safe

Frequently Asked Questions

Is 5-Methyl-2-Hepten-4-One safe in cosmetics?

Identified skin sensitizer with NESIL of 250 µg/cm²; α,β-unsaturated carbonyl structure presents Michael-addition reactivity risk with skin proteins; not phototoxic, not PBT, with PEC/PNEC ratio below 1. The EU classifies 5-Methyl-2-Hepten-4-One as "permitted". Safety rating: MODERATE.

Is 5-Methyl-2-Hepten-4-One allowed in the EU?

5-Methyl-2-Hepten-4-One EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does 5-Methyl-2-Hepten-4-One do in cosmetics?

5-Methyl-2-Hepten-4-One functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 81925-81-7 (trans-isomer: 102322-83-8).

What is the Margin of Safety for 5-Methyl-2-Hepten-4-One?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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