Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization Profile
Contact sensitization data for 6-Hydroxyindole based on clinical patch test studies and IFRA standards.
Source: SCCS; IVDK
Expert Verdict
Restricted in EU to 0.5% maximum in oxidative hair dye formulations with labeling requirements per Annex III. Permitted in US for oxidative hair dye use.
Regulatory Flags
Frequently Asked Questions
Is 6-Hydroxyindole safe in cosmetics?
Restricted in EU to 0.5% maximum in oxidative hair dye formulations with labeling requirements per Annex III. Permitted in US for oxidative hair dye use. The EU classifies 6-Hydroxyindole as "restricted". Safety rating: GOOD.
Is 6-Hydroxyindole allowed in the EU?
6-Hydroxyindole EU regulatory status: restricted. Maximum allowed concentration: 0.5%. This is based on EU Regulation 1223/2009 and its amendments.
What does 6-Hydroxyindole do in cosmetics?
6-Hydroxyindole functions as: Hair colorant (oxidative hair dye). It is classified as a cosmetic ingredient in our database. CAS number: 2380-86-1 (per CIR/SCCP records).
What is the Margin of Safety for 6-Hydroxyindole?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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