Regulatory Status
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Safety Data
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Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
d palmitoyl tetrapeptide-7 as used in cosmetics.2 The Panel concluded that these ingredients are safe in cosmetics in the present practices of use and concentration, as described in that safety assessment. (This report is available on the Cosmetic Ingredient Review (CIR) website: https://cir-reports.
Expert Verdict
Acetyl Hexapeptide-8 (Argireline) is a neurotransmitter-inhibiting peptide that competitively binds to SNAP-25 binding sites on the SNARE complex to inhibit acetylcholine exocytosis, with wrinkle depth reduction up to 30% at 10% concentration over 30 days and reported toxicity 4,000 times lower than botulinum toxin, though ocular surface impact via blink disruption has been documented.
Regulatory Flags
Frequently Asked Questions
Is Acetyl Hexapeptide-8 safe in cosmetics?
Acetyl Hexapeptide-8 (Argireline) is a neurotransmitter-inhibiting peptide that competitively binds to SNAP-25 binding sites on the SNARE complex to inhibit acetylcholine exocytosis, with wrinkle depth reduction up to 30% at 10% concentration over 30 days and reported toxicity 4,000 times lower than botulinum toxin, though ocular surface impact via blink disruption has been documented. The EU classifies Acetyl Hexapeptide-8 as "permitted". Safety rating: MODERATE. This ingredient has been reviewed by cir.
Is Acetyl Hexapeptide-8 allowed in the EU?
Acetyl Hexapeptide-8 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Acetyl Hexapeptide-8 do in cosmetics?
Acetyl Hexapeptide-8 functions as: Skin-conditioning agent; neuromodulating peptide. It is classified as a Active Ingredient in our database. CAS number: 616204-22-9.
What is the Margin of Safety for Acetyl Hexapeptide-8?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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