Acetyl Tripeptide-54 Amide

INCI: ACETYL TRIPEPTIDE-54 AMIDE (TRADE NAME: ADIPONIN)

CAS Number
Not publicly assigned / not available in major databases
Function
Skin Conditioning - promotes keratinocyte proliferation, increases ECM protein and GAG production, anti-wrinkle, barrier repair, moisturizing
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status restricted
US Notes Not specifically restricted; permitted under general cosmetic use. No CIR assessment

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Higher typical use concentration (1-5%) vs. most cosmetic peptides; limited independent peer-reviewed safety data; no SCCS or CIR opinion; lipo-peptide nature may enhance dermal penetration

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Concern Level: Low

Frequently Asked Questions

Is Acetyl Tripeptide-54 Amide safe in cosmetics?

Higher typical use concentration (1-5%) vs. most cosmetic peptides; limited independent peer-reviewed safety data; no SCCS or CIR opinion; lipo-peptide nature may enhance dermal penetration The EU classifies Acetyl Tripeptide-54 Amide as "permitted". Safety rating: GOOD.

Is Acetyl Tripeptide-54 Amide allowed in the EU?

Acetyl Tripeptide-54 Amide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Acetyl Tripeptide-54 Amide do in cosmetics?

Acetyl Tripeptide-54 Amide functions as: Skin Conditioning - promotes keratinocyte proliferation, increases ECM protein and GAG production, anti-wrinkle, barrier repair, moisturizing. It is classified as a cosmetic ingredient in our database. CAS number: Not publicly assigned / not available in major databases.

What is the Margin of Safety for Acetyl Tripeptide-54 Amide?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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