Moderate Cosmetic Ingredient NOAEL Data GHS Classified

ACRYLAMIDE

CAS Number
79-06-1
Function
Not Reported
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status Restricted
EU Max Conc. II/681
๐Ÿ‡บ๐Ÿ‡ธ US Status restricted
US Notes CIR: SQ - IJT 24(Suppl. 2):21-50, 2005

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
NOAEL: No definitive NOAEL โ€“ EFSA 2015 opinion treats acrylamide as a genotoxic carcinogen and uses BMDL10 values (0.17โ€“0.43 mg/kg bw/day) rather than a NOAEL | Source: EFSA Panel on Contaminants in the Food Chain (CONTAM), Scientific opinion on acrylamide in food (...

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for ACRYLAMIDE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 0.5 mg/kg bw/day oral rat oral REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word
DANGER
Pictograms
skull;toxic; cancer;health haz
Hazard Statements
Toxic if swallowed Harmful in contact with skin or if inhaled Causes skin irritation Causes serious eye irritation May cause an allergic skin reaction May cause genetic defects May cause cancer Suspected of damaging fertility or the unborn child Causes damage to nervous system Causes damage to the nervous system through prolonged or repeated exposure
Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the nervous system. The effects may be delayed.
Long-term Exposure Effects
Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the nervous system. This may result in peripheral nerve damage. This substance is probably carcinogenic to humans. May cause heritable genetic damage to human germ cells. May cause toxicity to human reproduction or development. Repeated or prolonged contact with skin may cause dermatitis. See Notes.
Routes of Exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

Expert Verdict

ACRYLAMIDE is listed in the EU CosIng database with functions: Not Reported It is restricted under EU Cosmetics Regulation. Restriction: II/681.

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Concern Level: Medium

Regulatory Flags

cosing-sourced eu-restricted needs-enrichment prop65 eu_banned_cosmetics eu_cosing_listed

Frequently Asked Questions

Is ACRYLAMIDE safe in cosmetics?

ACRYLAMIDE is listed in the EU CosIng database with functions: Not Reported It is restricted under EU Cosmetics Regulation. Restriction: II/681. The EU classifies ACRYLAMIDE as "Restricted". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.

Is ACRYLAMIDE allowed in the EU?

ACRYLAMIDE EU regulatory status: Restricted. Maximum allowed concentration: II/681. This is based on EU Regulation 1223/2009 and its amendments.

What does ACRYLAMIDE do in cosmetics?

ACRYLAMIDE functions as: Not Reported. It is classified as a cosmetic ingredient in our database. CAS number: 79-06-1.

What is the Margin of Safety for ACRYLAMIDE?

NOAEL: No definitive NOAEL โ€“ EFSA 2015 opinion treats acrylamide as a genotoxic carcinogen and uses BMDL10 values (0.17โ€“0.43 mg/kg bw/day) rather than a NOAEL | Source: EFSA Panel on Contaminants in the Food Chain (CONTAM), Scientific opinion on acrylamide in food (... The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for ACRYLAMIDE?

The NOAEL (No Observed Adverse Effect Level) for ACRYLAMIDE is 0.5 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.

Is ACRYLAMIDE classified as hazardous under GHS?

ACRYLAMIDE carries a GHS signal word of "DANGER". Hazard statements: Toxic if swallowed Harmful in contact with skin or if inhaled Causes skin irritation Causes serious eye irritation May cause an allergic skin reaction May cause genetic defects May cause cancer Suspected of damaging fertility or the unborn child Causes damage to nervous system Causes damage to the nervous system through prolonged or repeated exposure. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance โ€” at cosmetic use concentrations, hazard thresholds may not be met.

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