Is ACRYLAMIDE safe in cosmetics?
ACRYLAMIDE has a safety rating of "MODERATE" in our database. EU status: restricted. US status: restricted. 10 toxicological study endpoint(s) are available in our database.
ACRYLAMIDE
Also known as: 2-Propenamide, Acrylagel, Amresco Acryl-40, BRN 0605349, EINECS 201-173-7 (+8 more)
ACRYLAMIDE (CAS 79-06-1) is a cosmetic cosmetic ingredient functioning as Not Reported. NOAEL 0.5 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted, max II/681; GHS signal word DANGER. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 79-06-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
ACRYLAMIDE is classified GHS Danger (H301, H312, H315, H317, H319, H332, H340, H350) in the chemicals database but is restricted in EU cosmetics at max II/681.
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Not Reported
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
prop-2-enamide
InChIKey
HRPVXLWXLXDGHG-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
EU Max Conc.
II/681
US US Status
restricted
US Notes
CIR: SQ - IJT 24(Suppl. 2):21-50, 2005
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for ACRYLAMIDE.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for ACRYLAMIDE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.00023 mg/kg bw/day | - | Rat | Toxicology study | INCHEM_WHO_jecfa_jecmono_v63je01 |
| NOAEL | =0.00023 mg/kg bw/day | - | Rat | Toxicology study | INCHEM_WHO_jecfa_jecmono_v63je01 |
| NOAEL | =0.003 mg/kg bw/day | oral | - | Toxicology study | INCHEM_WHO_jecfa_jecmono_v63je01 |
| NOAEL | =0.003 mg/kg bw/day | oral | - | Toxicology study | INCHEM_WHO_jecfa_jecmono_v63je01 |
| NOAEL | =0.00428571428571429 mg/kg bw/day | - | - | Toxicology study | INCHEM_WHO_jecfa_jecmono_v63je01 |
| NOAEL | =0.00428571428571429 mg/kg bw/day | - | - | Toxicology study | INCHEM_WHO_jecfa_jecmono_v63je01 |
| NOAEL | =0.006 mg/kg bw/day | - | - | Toxicology study | INCHEM_WHO_jecfa_jecmono_v63je01 |
| NOAEL | =0.006 mg/kg bw/day | - | - | Toxicology study | INCHEM_WHO_jecfa_jecmono_v63je01 |
| NOAEL | =0.088 mg/kg bw/day | oral | - | Toxicology study | INCHEM_WHO_jecfa_jecmono_v63je01 |
| NOAEL | =0.088 mg/kg bw/day | oral | - | Toxicology study | INCHEM_WHO_jecfa_jecmono_v63je01 |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
DANGER
Pictograms
SkullToxicCancerHealth haz
Hazard Statements
Toxic if swallowed Harmful in contact with skin or if inhaled Causes skin irritation Causes serious eye irritation May cause an allergic skin reaction May cause genetic defects May cause cancer Suspected of damaging fertility or the unborn child Causes damage to nervous system Causes damage to the nervous system through prolonged or repeated exposure
Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the nervous system. The effects may be delayed.
Long-term Exposure Effects
Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the nervous system. This may result in peripheral nerve damage. This substance is probably carcinogenic to humans. May cause heritable genetic damage to human germ cells. May cause toxicity to human reproduction or development. Repeated or prolonged contact with skin may cause dermatitis. See Notes.
Routes of Exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for ACRYLAMIDE across SCCS product categories, with measured dermal absorption where available.
EPA ToxValDB — Toxicity Values
10 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| cancer slope factor | =4.5 (mg/kg-day)-1 | Human | inhalation | chronic | Cal OEHHA |
| cancer slope factor | =4.5 (mg/kg-day)-1 | Human | oral | chronic | Cal OEHHA |
| LOEL | =0.05 mg/kg-day | Rat | oral | short-term | ECOTOX |
| LOEL | =10 mg/kg-day | Rat | oral | short-term | ECOTOX |
| LOEL | =5 mg/kg-day | Rat | oral | short-term | ECOTOX |
| MRL | =0.01 mg/kg-day | Human | oral | - | ATSDR MRLs |
| MRL | =0.001 mg/kg-day | Human | oral | - | ATSDR MRLs |
| MRL | =0.001 mg/kg-day | Human | oral | - | ATSDR MRLs |
| LOEL | =1.05 mg/kg-day | Mouse | oral | chronic | WHO JECFA Tox Studies |
| NOAEL | =0.67 mg/kg-day | Rat | oral | chronic | WHO JECFA Tox Studies |
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
2A
Volume
60, Sup 7
Evaluation Year
1994
NB Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Health HazardAcute Toxicity
Hazard Class and Category
Carc. 1B; Muta. 1B; Repr. 2; Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 3 *; STOT RE 1; Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1
Hazard Statements
- H350 May cause cancer
- H340 May cause genetic defects
- H361f ***
- H332 Harmful if inhaled
- H312 Harmful in contact with skin
- H301 Toxic if swallowed
- H372 **
- H315 Causes skin irritation
- H319 Causes serious eye irritation
- H317 May cause an allergic skin reaction
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100,000 - 1,000,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
Yes (since 30-Mar-2010)
Hazard classification: Restricted (Annex XVII)
SVHC reason: Carcinogenic (Article 57a)
Substance of Very High Concern (SVHC)
Included: 30-Mar-2010
Carcinogenic (Article 57a); Mutagenic (Article 57b)
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 681
(EC) 2009/1223
CMR: Carcinogenic Cat. 1B(),Mutagenic Cat. 1B(),Reprotoxic Cat. 2()
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
ASEAN Cosmetic Directive (II)
Ref: 681
BRIN Brazil/India Cosmetics
Brazil: Prohibited
India: Prohibited (GNRAS)
Additional Jurisdictional Restrictions (2)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| BR | banned | - | Trace: rinse-off products 0.1 mg/kg residual; others 0.5 mg/kg |
| CA | banned | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (7)
Carcinogen Classification
2A, probably carcinogenic to humans. (L135)
Source: Toxin and Toxin Target Database (T3DB)
Carcinogen Classification
Acrylamide | Group 2A: Probably carcinogenic to humans | Volume 60: (1994) Some Industrial Chemicals | Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print) | NB Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
Source: International Agency for Research on Cancer (IARC)
Carcinogen Classification
Acrylamide | TR-575: Toxicology and Carcinogenesis Studies of Acrylamide (CASRN 79-06-1) in F344/N Rats and B6C3F1 Mice (Feed and Drinking Water Studies) (2012 ) | 04/05/11 | Clear Evidence | Clear Evidence | Clear Evidence | Clear Evidence | Under the conditions of these 2-year drinking water studies, there was clear evidence of carcinogenic activity of acrylamide in male F344/N rats bas
Source: NTP Technical Reports
Evidence for Carcinogenicity
Cancer Classification: Group B2 Probable Human Carcinogen | In accordance with the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005, 086237), acrylamide (AA) is characterized as "likely to be carcinogenic to humans." This characterization is based on the following findings: (1) chronic oral exposure of F344 rats to AA in drinking water induced statistically significant increased incidence
Source: Hazardous Substances Data Bank (HSDB)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Regulatory (1)
JECFA Evaluation
ACRYLAMIDE | 2011 | While adverse neurological effects are unlikely at the estimated average exposure, morphological changes in nerves cannot be excluded for individuals with a high dietary exposure to acrylamide. For a compound that is both genotoxic and carcinogenic, these MOEs indicate a health concern. The Committee noted that mitigation after 2003 has been reported for food types with high ac
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
No specific technical function
Regulatory List Membership (4)
California Proposition 65 (OEHHA)
EU Banned in Cosmetics
FDA Indirect Food Contact Additives
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for ACRYLAMIDE.
Regulatory Flags
cosing-sourced
eu-restricted
needs-enrichment
prop65
eu_banned_cosmetics
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to ACRYLAMIDE by CAS number or substance name.
Studies
38
Lowest NOAEL
0.00023 mg/kg bw/day
Highest NOAEL
15 mg/kg bw/day
INCHEM_WHO_jecfa_jecmono_v63je01
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
2-Propenamide
Acrylagel
Amresco Acryl-40
BRN 0605349
EINECS 201-173-7
Optimum
Propeneamide
Propenoic acid amide
RCRA waste number U007
Akrylamid
Amid kyseliny akrylove
UNII-20R035KLCI
prop-2-enamide
Chemical Function
No specific technical function
Regulatory Lists
Indirect additives food contact (10/2018)
OEHHA Proposition 65 (3/2019)
fracking; water
banned; Europe
air; drinking_water; Europe
Europe; Toys and children's products
children; Europe
Europe
Europe; Food contact items; Toys and children's products
Europe; Food contact items; Toys and children's products
OEHHA Proposition 65 (1/2023)
banned; Europe; Personal care
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ACRYLAMIDE
ChEMBL ID
CHEMBL348107
Frequently Asked Questions
Is ACRYLAMIDE allowed in the EU?
ACRYLAMIDE EU regulatory status: restricted. Maximum allowed concentration: II/681. This is based on EU Regulation 1223/2009 and its amendments.
What does ACRYLAMIDE do in cosmetics?
ACRYLAMIDE functions as: Not Reported. It is classified as a cosmetic ingredient in our database. CAS number: 79-06-1.
What is the NOAEL for ACRYLAMIDE?
The NOAEL (No Observed Adverse Effect Level) for ACRYLAMIDE is =0.00023 mg/kg bw/day based on a Toxicology study study via oral route in Rat. A total of 10 study endpoints are available. Source: INCHEM_WHO_jecfa_jecmono_v63je01.
Is ACRYLAMIDE classified as hazardous under GHS?
ACRYLAMIDE carries a GHS signal word of "DANGER". Hazard statements: Toxic if swallowed Harmful in contact with skin or if inhaled Causes skin irritation Causes serious eye irritation May cause an allergic skin reaction May cause genetic defects May cause cancer Suspected of damaging fertility or the unborn child Causes damage to nervous system Causes damage to the nervous system through prolonged or repeated exposure. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is ACRYLAMIDE used outside cosmetics?
ACRYLAMIDE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does ACRYLAMIDE have different safety status in cosmetics vs industrial chemicals?
ACRYLAMIDE is classified GHS Danger (H301, H312, H315, H317, H319, H332, H340, H350) in the chemicals database but is restricted in EU cosmetics at max II/681.
Compliance Tools
Check ACRYLAMIDE compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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