Excellent Cosmetic Ingredient NOAEL Data

Algin

INCI: ALGIN

CAS Number
9005-38-3
Function
gelling agent, thickener, film-forming agent, emulsion stabilizer
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes GRAS for food (FDA); widely used in cosmetics. No US restrictions.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Algin. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 7500 mg/kg bw/day oral mouse Chronic COSMOS_DB
NOAEL 5000 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 2000 mg/kg bw/day oral guinea pig Chronic COSMOS_DB
NOAEL 2500 mg/kg bw/day oral cat Subchronic COSMOS_DB
NOAEL 11250 mg/kg bw/day oral dog Chronic COSMOS_DB
NOAEL 37500 mg/kg bw/day oral mouse Carcinogenicity COSMOS_DB
dose_tested 7500 mg/kg bw/day oral mouse Chronic COSMOS_DB
dose_tested 5000 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
dose_tested 2000 mg/kg bw/day oral guinea pig Chronic COSMOS_DB
dose_tested 2500 mg/kg bw/day oral cat Subchronic COSMOS_DB

Expert Verdict

INCI name for Sodium Alginate. Marine-derived biopolymer with ionotropic gelation via calcium crosslinking. Key ingredient for cold-processable emulsions, silky serums, and jelly mask textures as a synthetic polymer replacement. Fully biodegradable and exempt from EU REACH SPM restriction. COSMOS-eligible.

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Concern Level: None

Regulatory Flags

eu-compliant biodegradable reach-spm-exempt natural-polymer marine-sourced cosmos-eligible gras ionotropic-gelation acrylate-replacement carbomer-alternative eu_children_restricted ifra_fragrance fda_food_additive

Frequently Asked Questions

Is Algin safe in cosmetics?

INCI name for Sodium Alginate. Marine-derived biopolymer with ionotropic gelation via calcium crosslinking. Key ingredient for cold-processable emulsions, silky serums, and jelly mask textures as a synthetic polymer replacement. Fully biodegradable and exempt from EU REACH SPM restriction. COSMOS-eligible. The EU classifies Algin as "permitted". Safety rating: EXCELLENT. 10 toxicological study endpoint(s) are available in our database.

Is Algin allowed in the EU?

Algin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Algin do in cosmetics?

Algin functions as: gelling agent, thickener, film-forming agent, emulsion stabilizer. It is classified as a cosmetic ingredient in our database. CAS number: 9005-38-3.

What is the Margin of Safety for Algin?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Algin?

The NOAEL (No Observed Adverse Effect Level) for Algin is 7500 mg/kg bw/day based on a Chronic study via oral route in mouse. A total of 10 study endpoints are available. Source: COSMOS_DB.

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