Ammonium Monofluorophosphate

INCI: AMMONIUM MONOFLUOROPHOSPHATE

CAS Number
20859-38-5 / 66115-19-3
Function
Oral care (anticaries agent, antiplaque)
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
EU Max Conc. 0.15%
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes FDA recognizes monofluorophosphate salts as anticaries active ingredients in OTC oral care products (21 CFR 355). Regulated as an OTC drug active, not merely a cosmetic ingredient.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Restricted use in oral care products only. Systemic fluoride toxicity risk if ingested in excess; strict concentration and labeling requirements apply in the EU. Not permitted in leave-on or non-oral products.

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Concern Level: High

Frequently Asked Questions

Is Ammonium Monofluorophosphate safe in cosmetics?

Restricted use in oral care products only. Systemic fluoride toxicity risk if ingested in excess; strict concentration and labeling requirements apply in the EU. Not permitted in leave-on or non-oral products. The EU classifies Ammonium Monofluorophosphate as "restricted". Safety rating: GOOD.

Is Ammonium Monofluorophosphate allowed in the EU?

Ammonium Monofluorophosphate EU regulatory status: restricted. Maximum allowed concentration: 0.15%. This is based on EU Regulation 1223/2009 and its amendments.

What does Ammonium Monofluorophosphate do in cosmetics?

Ammonium Monofluorophosphate functions as: Oral care (anticaries agent, antiplaque). It is classified as a cosmetic ingredient in our database. CAS number: 20859-38-5 / 66115-19-3.

What is the Margin of Safety for Ammonium Monofluorophosphate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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