Is Arctigenin safe in cosmetics?
Arctigenin has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Arctigenin
Also known as: 2(3H)-Furanone, 4-((3,4-dimethoxyphenyl)methyl)dihydro-3-((4-hydroxy-3-methoxyphenyl)methyl)-, (3R,4R)-, 2(3H)-Furanone, 4-((3,4-dimethoxyphenyl)methyl)dihydro-3-((4-hydroxy-3-methoxyphenyl)methyl)-, (3R-trans)-, 4-[(3,4-Dimethoxyphenyl)methyl]-3-[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one
INCI: ARCTIGENIN
Arctigenin (CAS 7770-78-7) is a cosmetic cosmetic ingredient functioning as Skin Conditioning; antioxidant, anti-inflammatory, and skin-lightening activity. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 7770-78-7 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Conditioning; antioxidant, anti-inflammatory, and skin-lightening activity
Safety Rating
MODERATE
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not specifically regulated by FDA; no CIR safety assessment published
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Arctigenin.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Expert Verdict
Expert safety assessment and concern-level summary for Arctigenin.
Known Synonyms
2(3H)-Furanone, 4-((3,4-dimethoxyphenyl)methyl)dihydro-3-((4-hydroxy-3-methoxyphenyl)methyl)-, (3R,4R)-
2(3H)-Furanone, 4-((3,4-dimethoxyphenyl)methyl)dihydro-3-((4-hydroxy-3-methoxyphenyl)methyl)-, (3R-trans)-
4-[(3,4-Dimethoxyphenyl)methyl]-3-[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one
Chemical Function
Antioxidant
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ARCTIGENIN
ChEMBL ID
CHEMBL435734
Frequently Asked Questions
Is Arctigenin allowed in the EU?
Arctigenin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Arctigenin do in cosmetics?
Arctigenin functions as: Skin Conditioning; antioxidant, anti-inflammatory, and skin-lightening activity. It is classified as a cosmetic ingredient in our database. CAS number: 7770-78-7.
Is Arctigenin used outside cosmetics?
Arctigenin also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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