Artepillin C

INCI: ARTEPILLIN C

CAS Number
72944-19-5
Function
Antioxidant, antimicrobial, anti-inflammatory agent derived from Brazilian green propolis
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No FDA cosmetic monograph; primarily a research compound. If used, manufacturer bears burden of safety substantiation under MoCRA.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Cytotoxic at higher concentrations with published CC50 data against carcinoma cells; no established cosmetic use level and propolis derivatives are known allergens in sensitive populations.

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Concern Level: High

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Artepillin C safe in cosmetics?

Cytotoxic at higher concentrations with published CC50 data against carcinoma cells; no established cosmetic use level and propolis derivatives are known allergens in sensitive populations. The EU classifies Artepillin C as "permitted". Safety rating: MODERATE.

Is Artepillin C allowed in the EU?

Artepillin C EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Artepillin C do in cosmetics?

Artepillin C functions as: Antioxidant, antimicrobial, anti-inflammatory agent derived from Brazilian green propolis. It is classified as a cosmetic ingredient in our database. CAS number: 72944-19-5.

What is the Margin of Safety for Artepillin C?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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