Excellent Active Ingredient

Ascorbyl Tetraisopalmitate

INCI: ASCORBYL TETRAISOPALMITATE

CAS Number
183476-82-6
Function
Oil-soluble vitamin C derivative; tyrosinase inhibitor; antioxidant; requires esterase-mediated hydrolysis to release ascorbic acid in skin; brightening active in anhydrous and oil-dominant formulations
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No FDA restriction. Allergic contact dermatitis cases published; use with caution. Not recommended as primary brightening active where alternatives with better safety records exist.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
high
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

CIR safe as used (2022 update). Oil-soluble vitamin C derivative with superior stability shielded from oxidation. Lipophilic with limited systemic exposure. EU unrestricted and Korea MFDS approved functional cosmetic whitening active. Primary concern is allergic contact dermatitis cases; not recommended as primary brightening choice where alternatives with better safety records exist.

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Concern Level: Moderate

Regulatory Flags

cir-safe-as-used-2022 eu-unrestricted oil-soluble superior-stability lipophilic korea-functional-cosmetic-whitening

Frequently Asked Questions

Is Ascorbyl Tetraisopalmitate safe in cosmetics?

CIR safe as used (2022 update). Oil-soluble vitamin C derivative with superior stability shielded from oxidation. Lipophilic with limited systemic exposure. EU unrestricted and Korea MFDS approved functional cosmetic whitening active. Primary concern is allergic contact dermatitis cases; not recommended as primary brightening choice where alternatives with better safety records exist. The EU classifies Ascorbyl Tetraisopalmitate as "permitted". Safety rating: EXCELLENT.

Is Ascorbyl Tetraisopalmitate allowed in the EU?

Ascorbyl Tetraisopalmitate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Ascorbyl Tetraisopalmitate do in cosmetics?

Ascorbyl Tetraisopalmitate functions as: Oil-soluble vitamin C derivative; tyrosinase inhibitor; antioxidant; requires esterase-mediated hydrolysis to release ascorbic acid in skin; brightening active in anhydrous and oil-dominant formulations. It is classified as a Active Ingredient in our database. CAS number: 183476-82-6.

What is the Margin of Safety for Ascorbyl Tetraisopalmitate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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