Good Cosmetic Ingredient

Astragalus Sinicus Extract

INCI: ASTRAGALUS SINICUS EXTRACT

CAS Number
223749-21-1
Function
Skin conditioning, antioxidant, anti-inflammatory, hair conditioning, soothing
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Not listed in FDA 21 CFR prohibited or restricted cosmetic ingredients; no OTC monograph coverage; used freely in cosmetics under general safety obligation (MoCRA 2022). No CIR dedicated safety assessment found; not on FDA prohibited/restricted list. Supported by traditional East Asian medicinal use of Chinese milk vetch. Clinical trial at 0.2% in cream pack for 8 weeks demonstrated no adverse effects with improvements in pigmentation, elasticity, and moisture.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Safe for use at typical cosmetic concentrations (0.1–2%); demonstrated skin conditioning, anti-inflammatory, antioxidant, and hair growth-promoting activity; no cytotoxicity up to 60 mg/mL; 8-week clinical trial at 0.2% well-tolerated with positive outcomes; not prohibited or restricted in EU or US.

⚠️
Concern Level: Low

Regulatory Flags

plant-extract leguminosae-family no-cir-assessment no-sccs-opinion ewg-not-indexed skin-conditioning anti-inflammatory antioxidant hair-conditioning mos-estimated chinese-medicine-history traditional-use

Frequently Asked Questions

Is Astragalus Sinicus Extract safe in cosmetics?

Safe for use at typical cosmetic concentrations (0.1–2%); demonstrated skin conditioning, anti-inflammatory, antioxidant, and hair growth-promoting activity; no cytotoxicity up to 60 mg/mL; 8-week clinical trial at 0.2% well-tolerated with positive outcomes; not prohibited or restricted in EU or US. The EU classifies Astragalus Sinicus Extract as "permitted". Safety rating: GOOD.

Is Astragalus Sinicus Extract allowed in the EU?

Astragalus Sinicus Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Astragalus Sinicus Extract do in cosmetics?

Astragalus Sinicus Extract functions as: Skin conditioning, antioxidant, anti-inflammatory, hair conditioning, soothing. It is classified as a cosmetic ingredient in our database. CAS number: 223749-21-1.

What is the Margin of Safety for Astragalus Sinicus Extract?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Astragalus Sinicus Extract compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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