NOAEL Studies Cosmetic Ingredient

Basic Brown 17 NOAEL Studies

INCI: BASIC BROWN 17

CAS: 16581-71-8

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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SCCS Opinion 9 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =60 mg/kg bw/day - - Chronic genotoxicity p.18
SCCS Opinion NOAEL =77.4 % - - Chronic genotoxicity p.18
SCCS Opinion NOAEL =120 mg/kg bw/day - - - NOAEL study p.23
SCCS Opinion NOAEL =240 mg/kg bw/day human - - NOAEL study p.23
SCCS Opinion NOAEL =46 mg/kg bw/day rabbit dermal 14 days dermal absorption p.24
SCCS Opinion NOAEL =93 mg/kg bw/day rabbit dermal 14 days dermal absorption p.24
SCCS Opinion NOAEL =0.023 mg/kg bw rat oral 90-day dermal absorption p.30
SCCS Opinion NOAEL =46 mg/kg bw/d rat oral 90-day dermal absorption p.30
SCCS Opinion NOAEL =23 mg/kg bw/d rat oral 90-day dermal absorption p.30
Regulatory source 19 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 120 mg/kg bw/day - - - - p.23
Regulatory source - 120 mg/kg bw/day human - - - p.23
Regulatory source - 240 mg/kg bw/day human - - - p.23
Regulatory source dermal absorption 46 mg/kg bw/day rabbit dermal 14 days dermal absorption p.24
Regulatory source dermal absorption 93 mg/kg bw/day rabbit dermal 14 days dermal absorption p.24
Regulatory source dermal absorption =0.023 mg/kg bw rat oral 90-day dermal absorption p.30
Regulatory source dermal absorption =46 mg/kg bw/d rat oral 90-day dermal absorption p.30
Regulatory source dermal absorption =23 mg/kg bw/d rat oral 90-day dermal absorption p.30
Regulatory source genotoxicity 60 mg/kg bw/day - - Chronic genotoxicity p.18
Regulatory source genotoxicity 77.4 % - - Chronic genotoxicity p.18
Regulatory source irritation 60 mg/kg bw/day rabbit - 14 days irritation p.24
Regulatory source irritation 77.4 % rabbit - 14 days irritation p.24
Regulatory source irritation 120 mg/kg bw/day - - - irritation p.29
Regulatory source irritation 120 mg/kg bw/day human - - irritation p.29
Regulatory source irritation 240 mg/kg bw/day human - - irritation p.29
Regulatory source reproductive toxicity 60 mg/kg bw/day - - 14 days reproductive toxicity p.30
Regulatory source reproductive toxicity 77.4 % - - 14 days reproductive toxicity p.30
Regulatory source reproductive toxicity 46 mg/kg bw/day - - 14 days reproductive toxicity p.30
Regulatory source reproductive toxicity 93 mg/kg bw/day - - 14 days reproductive toxicity p.30