NOAEL Studies Cosmetic Ingredient

Basic Orange 31 NOAEL Studies

INCI: BASIC ORANGE 31

CAS: 97404-02-9

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 229 mg/kg bw/day rat oral 90 day Subchronic SCCS; RCC Project 699647. (1999). Subchronic 13-week oral toxicity (feeding) study in therat
COSMOS DB NOAEL 66 mg/kg bw/day rat oral 90 day Subchronic SCCS; RCC Project 699647. (1999). Subchronic 13-week oral toxicity (feeding) study in therat
SCCNFP Opinion 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCNFP Opinion NOAEL =1 % - dermal - repeated dose toxicity Ref : 3 2, p.7
SCCNFP Opinion NOAEL =15 mg/kg rat dermal 14 days repeated dose toxicity Ref : 4 2, p.7
SCCNFP Opinion NOAEL =18 mg/kg rat dermal Sub-chronic repeated dose toxicity Ref : 5 2, p.9
SCCNFP Opinion NOAEL =18 mg/kg bw/day - oral sub-chronic repeated dose toxicity p.21
SCCNFP Opinion NOAEL =53 mg/kg bw rat dermal 14 days repeated dose toxicity Ref : 4 2, p.7
SCCNFP Opinion NOAEL =53 mg/kg bw/day - oral sub-chronic repeated dose toxicity p.21
SCCNFP Opinion NOAEL =60 mg/kg rat dermal Sub-chronic repeated dose toxicity Ref : 5 2, p.9
SCCNFP Opinion NOAEL =60 mg/kg bw/day - oral sub-chronic repeated dose toxicity p.21
SCCS Opinion 9 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =94.1 % rabbit dermal - irritation p.11
SCCS Opinion NOAEL =15 mg/kg bw/day rat oral Sub-chronic repeated dose toxicity p.18
SCCS Opinion NOAEL =53 mg/kg bw rat oral Sub-chronic repeated dose toxicity p.18
SCCS Opinion NOAEL =18 mg/kg bw/day rat - Chronic genotoxicity p.19
SCCS Opinion NOAEL =60 mg/kg bw/day rat - Chronic genotoxicity p.19
SCCS Opinion NOAEL =0.0013 mg/kg bw rat oral 90-day dermal absorption p.28
SCCS Opinion NOAEL =60 mg/kg bw rat oral 90-day dermal absorption p.28
SCCS Opinion NOAEL =0.0011 mg/kg bw rat oral 90-day dermal absorption p.29
SCCS Opinion NOAEL =53 mg/kg bw/day rat oral 28-day reproductive toxicity p.29
Regulatory source 20 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source developmental toxicity 60 mg/kg human - - developmental toxicity p.13
Regulatory source repeated dose toxicity 1 % - dermal - repeated dose toxicity p.7
Regulatory source repeated dose toxicity 15 mg/kg rat dermal 14 days repeated dose toxicity p.7
Regulatory source repeated dose toxicity 18 mg/kg rat dermal Sub-chronic repeated dose toxicity p.9
Regulatory source repeated dose toxicity 18 mg/kg bw/day - oral sub-chronic repeated dose toxicity p.21
Regulatory source repeated dose toxicity 53 mg/kg bw rat dermal 14 days repeated dose toxicity p.7
Regulatory source repeated dose toxicity 53 mg/kg bw/day - oral sub-chronic repeated dose toxicity p.21
Regulatory source repeated dose toxicity 60 mg/kg rat dermal Sub-chronic repeated dose toxicity p.9
Regulatory source repeated dose toxicity 60 mg/kg bw/day - oral sub-chronic repeated dose toxicity p.21
Regulatory source dermal absorption =0.0013 mg/kg bw rat oral 90-day dermal absorption p.28
Regulatory source dermal absorption =60 mg/kg bw rat oral 90-day dermal absorption p.28
Regulatory source dermal absorption =0.0011 mg/kg bw rat oral 90-day dermal absorption p.29
Regulatory source developmental toxicity 60 mg/kg bw/day mouse oral - developmental toxicity p.25
Regulatory source genotoxicity 18 mg/kg bw/day rat - Chronic genotoxicity p.19
Regulatory source genotoxicity 60 mg/kg bw/day rat - Chronic genotoxicity p.19
Regulatory source irritation 94.1 % rabbit dermal - irritation p.11
Regulatory source repeated dose toxicity 15 mg/kg bw/day rat oral Sub-chronic repeated dose toxicity p.18
Regulatory source repeated dose toxicity 53 mg/kg bw rat oral Sub-chronic repeated dose toxicity p.18
Regulatory source reproductive toxicity 53 mg/kg bw/day rat oral 28-day reproductive toxicity p.29
Regulatory source reproductive toxicity 60 mg/kg bw/day rat oral 28-day reproductive toxicity p.29
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier O1JIQ710E2 UNII - - - chemical -