NOAEL Studies Cosmetic Ingredient

Basic Red 51 NOAEL Studies

INCI: BASIC RED 51

CAS: 77061-58-6

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 10 mg/kg bw/day rat oral 91 day Subchronic SCCS; RCC Project 681322. (1998). Subchronic 13-week oral toxicity (feeding) study in therat
SCCNFP Opinion 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCNFP Opinion NOAEL =10 mg/kg/day - dermal Sub-chronic repeated dose toxicity Ref : 5 2, p.10
SCCNFP Opinion NOAEL =10 mg/kg bw/day - oral sub-chronic repeated dose toxicity p.20
SCCNFP Opinion NOAEL =12.25 mg/kg rat dermal 4 weeks repeated dose toxicity Ref : 4 2, p.8
SCCNFP Opinion NOAEL =12.25 mg/kg bw/day - oral sub-chronic repeated dose toxicity Ref. : 10 2, p.20
SCCNFP Opinion NOAEL =20 mg/kg bw/day human - - developmental toxicity Ref. : 11 2, p.13
SCCNFP Opinion NOAEL =50 mg/kg - dermal Sub-chronic repeated dose toxicity Ref : 5 2, p.10
SCCNFP Opinion NOAEL =180 mg/kg bw/day human - - developmental toxicity Ref. : 11 2, p.13
SCCS Opinion 9 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.005 mg/kg rat oral subchronic repeated dose toxicity p.29
SCCS Opinion NOAEL =0.006 mg/kg rat oral subchronic repeated dose toxicity p.28
SCCS Opinion NOAEL =10 mg/kg bw/day - - Chronic genotoxicity p.18
SCCS Opinion NOAEL =10 mg/kg bw rat oral subchronic repeated dose toxicity p.28
SCCS Opinion NOAEL =12.25 mg/kg rat dermal 14 days repeated dose toxicity p.16
SCCS Opinion NOAEL =20 mg/kg bw/day mouse oral - developmental toxicity p.24
SCCS Opinion NOAEL =50 mg/kg bw/d - - Chronic genotoxicity p.18
SCCS Opinion NOAEL =180 mg/kg bw/day mouse oral - developmental toxicity p.24
SCCS Opinion NOAEL =2000 mg/kg bw - oral sub-chronic repeated dose toxicity p.28
ECHA 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA NOEL =20 mg/kg bw/day Rat oral - reproduction developmental QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1cfe4b0a7c65d2303c5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23102/7/9/3?documentUUID=b65d9bd1-9885-419b-b112-cd6d2ae0cdc2; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain|maternal: clinical signs|maternal: food consumption and compound intake|maternal: mortality|maternal: pre and post implantation loss; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|mortality/survival|reproduction; STUDY_GROUP=ECHA IUCLID:15822261:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ef1a90d88e9e3dca57ca90c10aefd919
ECHA NOEL =180 mg/kg bw/day Rat oral - developmental QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1cfe4b0a7c65d2303c5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23102/7/9/3?documentUUID=b65d9bd1-9885-419b-b112-cd6d2ae0cdc2; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=fetus: changes in sex ratio|fetus: fetal/pup body weight changes|fetus: skeletal malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15820918:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a9d87503c7bb4089862f29569b6f597a
Regulatory source 20 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source developmental toxicity 20 mg/kg bw/day human - - developmental toxicity p.13
Regulatory source developmental toxicity 180 mg/kg bw/day human - - developmental toxicity p.13
Regulatory source repeated dose toxicity 10 mg/kg/day - dermal Sub-chronic repeated dose toxicity p.10
Regulatory source repeated dose toxicity 10 mg/kg bw/day - dermal Sub-chronic repeated dose toxicity p.10
Regulatory source repeated dose toxicity 10 mg/kg bw/day - oral sub-chronic repeated dose toxicity p.20
Regulatory source repeated dose toxicity 12.25 mg/kg rat dermal 4 weeks repeated dose toxicity p.8
Regulatory source repeated dose toxicity 12.25 mg/kg bw/day - oral sub-chronic repeated dose toxicity p.20
Regulatory source repeated dose toxicity 20 mg/kg bw/day - oral sub-chronic repeated dose toxicity p.20
Regulatory source repeated dose toxicity 50 mg/kg - dermal Sub-chronic repeated dose toxicity p.10
Regulatory source developmental toxicity 20 mg/kg bw/day mouse oral - developmental toxicity p.24
Regulatory source developmental toxicity 20 mg/kg bw/day - - - developmental toxicity p.24
Regulatory source developmental toxicity 180 mg/kg bw/day mouse oral - developmental toxicity p.24
Regulatory source developmental toxicity 180 mg/kg bw/day - - - developmental toxicity p.24
Regulatory source genotoxicity 10 mg/kg bw/day - - Chronic genotoxicity p.18
Regulatory source genotoxicity 50 mg/kg bw/d - - Chronic genotoxicity p.18
Regulatory source repeated dose toxicity =0.005 mg/kg rat oral subchronic repeated dose toxicity p.29
Regulatory source repeated dose toxicity =0.006 mg/kg rat oral subchronic repeated dose toxicity p.28
Regulatory source repeated dose toxicity =10 mg/kg bw rat oral subchronic repeated dose toxicity p.28
Regulatory source repeated dose toxicity 12.25 mg/kg rat dermal 14 days repeated dose toxicity p.16
Regulatory source repeated dose toxicity 2000 mg/kg bw - oral sub-chronic repeated dose toxicity p.28
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier A7A946JJ6I UNII - - - chemical -