NOAEL Studies
Preservative
Benzisothiazolinone NOAEL Studies
INCI: BENZISOTHIAZOLINONE
CAS: 2634-33-5
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
EFSA 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA | NOAEL | =10 | mg/kg bw/day | Rat | oral: gavage | 90 days | subchronic | EFSA AFC - 2007 - OutputID 307 - histopathology non neoplastic - systemic - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on the presence of 1,2-Benzisothiazolin-3-one as an impurity in saccharin used as a food additive - doi:10.2903/j.efsa.2007.416 |
| EFSA | NOAEL | =10 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=EFSA AFC (2007). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on the presence of 1,2-Benzisothiazolin-3-one as an impurity in saccharin used as a food additive. doi:10.2903/j.efsa.2007.416.; TITLE=Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on the presence of 1,2-Benzisothiazolin-3-one as an impurity in saccharin used as a food additive; AUTHOR=EFSA AFC; DOI=doi:10.2903/j.efsa.2007.416; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=histopathology: nonneoplastic; STUDY_GROUP=EFSA:15614272:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_170a5a52bc413e62f93314c110ec4bee |
NTP ICE acute dermal 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute dermal | EPA classification | 3 | unitless | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=1416; Record_ID=acute_dermal_6; Data_Type=In Vivo; Formulation_ID=MIX6; Formulation_Name=Acticide CBM; Percent_Active_Ingredient=3.75; Mixture=Mixture; DTXSID=DTXSID5032523; Assay=Rat Acute Dermal Toxicity; Endpoint=EPA classification; Response=3.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
| NTP ICE acute dermal | EPA classification | 4 | unitless | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=1426; Record_ID=acute_dermal_394; Data_Type=In Vivo; Formulation_ID=MIX388; Formulation_Name=Nuosept Bit; Percent_Active_Ingredient=84.0; Mixture=Mixture; DTXSID=DTXSID5032523; Assay=Rat Acute Dermal Toxicity; Endpoint=EPA classification; Response=4.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
| NTP ICE acute dermal | GHS classification | 5 | unitless | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=1420; Record_ID=acute_dermal_367; Data_Type=In Vivo; Formulation_ID=MIX360; Formulation_Name=Preventol BIT 20N; Percent_Active_Ingredient=20.5; Mixture=Mixture; DTXSID=DTXSID5032523; Assay=Rat Acute Dermal Toxicity; Endpoint=GHS classification; Response=5.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
| NTP ICE acute dermal | LD50 | >2000 | mg/kg | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=1419; Record_ID=acute_dermal_316; Data_Type=In Vivo; Formulation_ID=MIX309; Formulation_Name=Mergal K10N; Percent_Active_Ingredient=9.68; Mixture=Mixture; DTXSID=DTXSID5032523; Assay=Rat Acute Dermal Toxicity; Endpoint=LD50; Response_Modifier=>; Response=2000.0; Response_Unit=mg/kg; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
| NTP ICE acute dermal | LD50 | >5000 | mg/kg | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=1415; Record_ID=acute_dermal_367; Data_Type=In Vivo; Formulation_ID=MIX360; Formulation_Name=Preventol BIT 20N; Percent_Active_Ingredient=20.5; Mixture=Mixture; DTXSID=DTXSID5032523; Assay=Rat Acute Dermal Toxicity; Endpoint=LD50; Response_Modifier=>; Response=5000.0; Response_Unit=mg/kg; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
NTP ICE acute inhalation 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | GHS Classification | 2 | unitless | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3108; Record_ID=acute_inhalation_292; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX360; Formulation_Name=Preventol BIT 20N; Percent_Active_Ingredient=20.5; Mixture=Mixture; DTXSID=DTXSID5032523; Assay=Rat Acute Inhalation Toxicity; Endpoint=GHS Classification; Response=2; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
| NTP ICE acute inhalation | GHS Classification | 3 | unitless | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3107; Record_ID=acute_inhalation_26; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX6; Formulation_Name=Acticide CBM; Percent_Active_Ingredient=3.75; Mixture=Mixture; DTXSID=DTXSID5032523; Assay=Rat Acute Inhalation Toxicity; Endpoint=GHS Classification; Response=3; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
| NTP ICE acute inhalation | LC50 | >0.5 | mg/L | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3112; Record_ID=acute_inhalation_292; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX360; Formulation_Name=Preventol BIT 20N; Percent_Active_Ingredient=20.5; Mixture=Mixture; DTXSID=DTXSID5032523; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=0.5; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
| NTP ICE acute inhalation | LC50 | 0.73 | mg/L | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3111; Record_ID=acute_inhalation_26; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX6; Formulation_Name=Acticide CBM; Percent_Active_Ingredient=3.75; Mixture=Mixture; DTXSID=DTXSID5032523; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.73; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
NTP ICE acute oral 19 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | EPA classification | =3 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12803; row=9131; data_type=In Vivo; mixture=Mixture; formulation_id=MIX388; formulation_name=Nuosept Bit; chemical_name=1,2-Benzisothiazolin-3-one; preferred_name=1,2-Benzisothiazolin-3-one; percent_active_ingredient=84.0; dtxsid=DTXSID5032523; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523; source_file=acute_oral.xlsx |
| NTP ICE acute oral | EPA classification | =3 | Unitless | Rat | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_13156; row=9139; data_type=In Vivo; mixture=Mixture; formulation_id=MIX663; formulation_name=Acticide CBM 2; chemical_name=1,2-Benzisothiazolin-3-one; preferred_name=1,2-Benzisothiazolin-3-one; percent_active_ingredient=10.0; dtxsid=DTXSID5032523; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523; source_file=acute_oral.xlsx |
| NTP ICE acute oral | EPA classification | =3 | Unitless | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_13062; row=9142; data_type=In Vivo; mixture=Mixture; formulation_id=MIX518; formulation_name=Troysan 680; chemical_name=1,2-Benzisothiazolin-3-one; preferred_name=1,2-Benzisothiazolin-3-one; percent_active_ingredient=10.4; dtxsid=DTXSID5032523; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523; source_file=acute_oral.xlsx |
| NTP ICE acute oral | GHS classification | =4 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_13063; row=9128; data_type=In Vivo; mixture=Mixture; formulation_id=MIX518; formulation_name=Troysan 680; chemical_name=1,2-Benzisothiazolin-3-one; preferred_name=1,2-Benzisothiazolin-3-one; percent_active_ingredient=10.4; dtxsid=DTXSID5032523; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523; source_file=acute_oral.xlsx |
| NTP ICE acute oral | GHS classification | =4 | Unitless | Rat | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_13156; row=9145; data_type=In Vivo; mixture=Mixture; formulation_id=MIX663; formulation_name=Acticide CBM 2; chemical_name=1,2-Benzisothiazolin-3-one; preferred_name=1,2-Benzisothiazolin-3-one; percent_active_ingredient=10.0; dtxsid=DTXSID5032523; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523; source_file=acute_oral.xlsx |
| NTP ICE acute oral | GHS classification | =4 | Unitless | Rat (Male/Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12802; row=9153; data_type=In Vivo; mixture=Mixture; formulation_id=MIX388; formulation_name=Nuosept Bit; chemical_name=1,2-Benzisothiazolin-3-one; preferred_name=1,2-Benzisothiazolin-3-one; percent_active_ingredient=84.0; dtxsid=DTXSID5032523; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523; source_file=acute_oral.xlsx |
| NTP ICE acute oral | GHS classification | =5 | Unitless | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_13062; row=9124; data_type=In Vivo; mixture=Mixture; formulation_id=MIX518; formulation_name=Troysan 680; chemical_name=1,2-Benzisothiazolin-3-one; preferred_name=1,2-Benzisothiazolin-3-one; percent_active_ingredient=10.4; dtxsid=DTXSID5032523; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523; source_file=acute_oral.xlsx |
| NTP ICE acute oral | GHS classification | =5 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12185; row=9144; data_type=In Vivo; mixture=Mixture; formulation_id=MIX6; formulation_name=Acticide CBM; chemical_name=1,2-Benzisothiazolin-3-one; preferred_name=1,2-Benzisothiazolin-3-one; percent_active_ingredient=3.75; dtxsid=DTXSID5032523; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =1020 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_4759; row=9130; data_type=In Vivo; mixture=Chemical; chemical_name=1,2-Benzisothiazolin-3-one; preferred_name=1,2-Benzisothiazolin-3-one; dtxsid=DTXSID5032523; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =1030 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12859; row=9147; data_type=In Vivo; mixture=Mixture; formulation_id=MIX360; formulation_name=Preventol BIT 20N; chemical_name=1,2-Benzisothiazolin-3-one; preferred_name=1,2-Benzisothiazolin-3-one; percent_active_ingredient=20.5; dtxsid=DTXSID5032523; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =1050 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12803; row=9148; data_type=In Vivo; mixture=Mixture; formulation_id=MIX388; formulation_name=Nuosept Bit; chemical_name=1,2-Benzisothiazolin-3-one; preferred_name=1,2-Benzisothiazolin-3-one; percent_active_ingredient=84.0; dtxsid=DTXSID5032523; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =1367 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_13063; row=9123; data_type=In Vivo; mixture=Mixture; formulation_id=MIX518; formulation_name=Troysan 680; chemical_name=1,2-Benzisothiazolin-3-one; preferred_name=1,2-Benzisothiazolin-3-one; percent_active_ingredient=10.4; dtxsid=DTXSID5032523; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =1450 | mg/kg bw | Rat (Male/Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12802; row=9155; data_type=In Vivo; mixture=Mixture; formulation_id=MIX388; formulation_name=Nuosept Bit; chemical_name=1,2-Benzisothiazolin-3-one; preferred_name=1,2-Benzisothiazolin-3-one; percent_active_ingredient=84.0; dtxsid=DTXSID5032523; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =1759 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12729; row=9129; data_type=In Vivo; mixture=Mixture; formulation_id=MIX309; formulation_name=Mergal K10N; chemical_name=1,2-Benzisothiazolin-3-one; preferred_name=1,2-Benzisothiazolin-3-one; percent_active_ingredient=9.68; dtxsid=DTXSID5032523; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | >2000 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12185; row=9127; data_type=In Vivo; mixture=Mixture; formulation_id=MIX6; formulation_name=Acticide CBM; chemical_name=1,2-Benzisothiazolin-3-one; preferred_name=1,2-Benzisothiazolin-3-one; percent_active_ingredient=3.75; dtxsid=DTXSID5032523; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | >2000 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_13062; row=9141; data_type=In Vivo; mixture=Mixture; formulation_id=MIX518; formulation_name=Troysan 680; chemical_name=1,2-Benzisothiazolin-3-one; preferred_name=1,2-Benzisothiazolin-3-one; percent_active_ingredient=10.4; dtxsid=DTXSID5032523; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =2100 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12800; row=9157; data_type=In Vivo; mixture=Mixture; formulation_id=MIX388; formulation_name=Nuosept Bit; chemical_name=1,2-Benzisothiazolin-3-one; preferred_name=1,2-Benzisothiazolin-3-one; percent_active_ingredient=84.0; dtxsid=DTXSID5032523; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =2342 | mg/kg bw | Rat (Male/Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12728; row=9125; data_type=In Vivo; mixture=Mixture; formulation_id=MIX309; formulation_name=Mergal K10N; chemical_name=1,2-Benzisothiazolin-3-one; preferred_name=1,2-Benzisothiazolin-3-one; percent_active_ingredient=9.68; dtxsid=DTXSID5032523; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =3127 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12727; row=9126; data_type=In Vivo; mixture=Mixture; formulation_id=MIX309; formulation_name=Mergal K10N; chemical_name=1,2-Benzisothiazolin-3-one; preferred_name=1,2-Benzisothiazolin-3-one; percent_active_ingredient=9.68; dtxsid=DTXSID5032523; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523; source_file=acute_oral.xlsx |
NTP ICE adme parameters 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE adme parameters | Clint | 34.74 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=2122; Record_ID=adme_parameters_302; Data_Type=Measured; DTXSID=DTXSID5032523; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=34.74; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wetmore 2015; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
| NTP ICE adme parameters | Fu | 0 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=2123; Record_ID=adme_parameters_302; Data_Type=Measured; DTXSID=DTXSID5032523; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.0; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wetmore 2015; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
NTP ICE dart 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE dart | LOEL | 100 | mg/kg bw/day | Rat | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=87718; Record_ID=dart_4277; Data_Type=In Vivo; DTXSID=DTXSID5032523; Assay=DART, In life observation; Endpoint=LOEL; Response=100; Response_Unit=mg/kg/day; Species=Rat; Strain=Alpk:APfSD; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0005910;CUI;Body Weight|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0043094;CUI;Weight Gain; Reference=ToxRefDB v2 , ID = 6576; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
| NTP ICE dart | LOEL | 100 | mg/kg bw/day | Rat | Oral | - | In Vivo; DART, Developmental malformation | sheet=Data; excel_row=87719; Record_ID=dart_4384; Data_Type=In Vivo; DTXSID=DTXSID5032523; Assay=DART, Developmental malformation; Endpoint=LOEL; Response=100; Response_Unit=mg/kg/day; Species=Rat; Strain=Alpk:APfSD; Sex=Male/Female; Life_Stage=Fetal; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0000768;CUI;Congenital Abnormality|UMLS;C0265509;CUI;Congenital anomaly of skeletal bone|UMLS;C4086922;CUI;Unossified; Reference=ToxRefDB v2 , ID = 6576; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
NTP ICE endocrine 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | AC50 | 52.0485260077318 | uM | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=448; RecordID=ARPathway2016_132; DatasetName=ARPathway2016; DTXSID=DTXSID5032523; Assay=AR Pathway Model, Agonist; Endpoint=AC50; Response=52.0485260077318; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
| NTP ICE endocrine | ACC | 37.2171294089622 | uM | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=449; RecordID=ARPathway2016_132; DatasetName=ARPathway2016; DTXSID=DTXSID5032523; Assay=AR Pathway Model, Agonist; Endpoint=ACC; Response=37.2171294089622; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=451; RecordID=ARPathway2016_132; DatasetName=ARPathway2016; DTXSID=DTXSID5032523; Assay=AR Pathway Model, Agonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
| NTP ICE endocrine | Model Score | 0.121 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=450; RecordID=ARPathway2016_132; DatasetName=ARPathway2016; DTXSID=DTXSID5032523; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0.121; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
NTP ICE eye irritation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE eye irritation | EPA Classification | 1 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=1691; Record_ID=eye_irritation_252; Data_Type=In Vivo; Formulation_ID=EyeIrritation6pack_PID52; Formulation_Name=Acticide SR 8213 C; Percent_Active_Ingredient=10.0; Mixture=Mixture; DTXSID=DTXSID5032523; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=1; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
NTP ICE skin irritation 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin irritation | Breakthrough Time | 240 | min | - | Dermal | - | In Vitro; Corrositex | sheet=Data_invitro; excel_row=4077; Record_ID=skin_irritation_invitro_140; Data_Type=In Vitro; Formulation_ID=MIX795; Formulation_Name=Proxel AB; Percent_Active_Ingredient=33; Mixture=Mixture; DTXSID=DTXSID5032523; Assay=Corrositex; Endpoint=Breakthrough Time; Response=240; Response_Unit=min; Reference=Botham et al. 1995; Not available; 10.1177/026119299502300207; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
| NTP ICE skin irritation | EPA classification | 1 | unitless | Rabbit | Dermal | - | In Vivo; Draize Skin Irritation/Corrosion Test | sheet=Data_invivo; excel_row=1126; Record_ID=skin_irritation_invivo_519; Data_Type=In Vivo; Formulation_ID=MIX6; Formulation_Name=Acticide CBM; Percent_Active_Ingredient=3.75; Mixture=Mixture; DTXSID=DTXSID5032523; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=1; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
| NTP ICE skin irritation | EPA classification | 2 | unitless | Rabbit | Dermal | - | In Vivo; Draize Skin Irritation/Corrosion Test | sheet=Data_invivo; excel_row=1129; Record_ID=skin_irritation_invivo_755; Data_Type=In Vivo; Formulation_ID=MIX360; Formulation_Name=Preventol BIT 20N; Percent_Active_Ingredient=20.5; Mixture=Mixture; DTXSID=DTXSID5032523; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=2; Response_Unit=Unitless; Species=Rabbit; Reported_Strain=New Zealand White; Strain=New Zealand White; Sex=Male; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
| NTP ICE skin irritation | EPA classification | 3 | unitless | Rabbit | Dermal | - | In Vivo; Draize Skin Irritation/Corrosion Test | sheet=Data_invivo; excel_row=1124; Record_ID=skin_irritation_invivo_172; Data_Type=In Vivo; Formulation_ID=MIX388; Formulation_Name=Nuosept Bit; Percent_Active_Ingredient=84; Mixture=Mixture; DTXSID=DTXSID5032523; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=3; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
| NTP ICE skin irritation | EPA classification | 4 | unitless | Rabbit | Dermal | - | In Vivo; Draize Skin Irritation/Corrosion Test | sheet=Data_invivo; excel_row=1125; Record_ID=skin_irritation_invivo_431; Data_Type=In Vivo; Formulation_ID=MIX518; Formulation_Name=Troysan 680; Percent_Active_Ingredient=10.4; Mixture=Mixture; DTXSID=DTXSID5032523; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=4; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
| NTP ICE skin irritation | TER | 9.4 | kiloohms | - | Dermal | - | In Vitro; TER Corrosion | sheet=Data_invitro; excel_row=4068; Record_ID=skin_irritation_invitro_2518; Data_Type=In Vitro; Formulation_ID=MIX796; Formulation_Name=Proxel BD; Percent_Active_Ingredient=33; Mixture=Mixture; DTXSID=DTXSID5032523; Assay=TER Corrosion; Endpoint=TER; Response=9.4; Response_Unit=kiloohms; Reference=Botham et al. 1995; Not available; 10.1177/026119299502300207; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
| NTP ICE skin irritation | TER | 10.5 | kiloohms | - | Dermal | - | In Vitro; TER Corrosion | sheet=Data_invitro; excel_row=4069; Record_ID=skin_irritation_invitro_2517; Data_Type=In Vitro; Formulation_ID=MIX796; Formulation_Name=Proxel BD; Percent_Active_Ingredient=33; Mixture=Mixture; DTXSID=DTXSID5032523; Assay=TER Corrosion; Endpoint=TER; Response=10.5; Response_Unit=kiloohms; Reference=Botham et al. 1995; Not available; 10.1177/026119299502300207; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
| NTP ICE skin irritation | TER | 11 | kiloohms | - | Dermal | - | In Vitro; TER Corrosion | sheet=Data_invitro; excel_row=4076; Record_ID=skin_irritation_invitro_2515; Data_Type=In Vitro; Formulation_ID=MIX795; Formulation_Name=Proxel AB; Percent_Active_Ingredient=33; Mixture=Mixture; DTXSID=DTXSID5032523; Assay=TER Corrosion; Endpoint=TER; Response=11; Response_Unit=kiloohms; Reference=Botham et al. 1995; Not available; 10.1177/026119299502300207; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
NTP ICE skin sensitization 18 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | CD54, EC200 | 0.54 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3642; Record_ID=skin_sensitization_invitro_834; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5032523; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=0.54; Reported_Response_Unit=ug/mL; Response=0.54; Response_Unit=ug/mL; Reference=Ashikaga et al. 2010; 20822320; 10.1177/026119291003800403|Nukada et al. 2012; 22796097; 10.1016/j.tiv.2012.07.001|Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
| NTP ICE skin sensitization | CD54, EC200 | 0.55 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2069; Record_ID=skin_sensitization_invitro_515; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID5032523; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=0.55000000000000004; Reported_Response_Unit=ug/mL; Response=0.55; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
| NTP ICE skin sensitization | CD86, EC150 | 0.39 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8550; Record_ID=skin_sensitization_invitro_2359; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID5032523; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=0.39; Reported_Response_Unit=ug/mL; Response=0.39; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
| NTP ICE skin sensitization | CD86, EC150 | 0.55 | ug/mL | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; U-SENS | sheet=Data_invitro; excel_row=8257; Record_ID=skin_sensitization_invitro_2280; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID5032523; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=3.637566138; Reported_Response_Unit=uM; Conversion_Factor_Value=151.18; Conversion_Factor_Source=EPA Dashboard; Converted_Response=0.55; Converted_Response_Unit=ug/mL; Response=0.55; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
| NTP ICE skin sensitization | CV70 | 3.43 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8552; Record_ID=skin_sensitization_invitro_2359; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID5032523; Assay=U-SENS; Endpoint=CV70; Reported_Response=3.43; Reported_Response_Unit=ug/mL; Response=3.43; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
| NTP ICE skin sensitization | CV75 | 1.83 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2070; Record_ID=skin_sensitization_invitro_515; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID5032523; Assay=h-CLAT; Endpoint=CV75; Reported_Response=1.83; Reported_Response_Unit=ug/mL; Response=1.83; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
| NTP ICE skin sensitization | Depletion Cys | 97.7 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=341; Record_ID=skin_sensitization_invitro_109; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5032523; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=97.7; Reported_Response_Unit=%; Response=97.7; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
| NTP ICE skin sensitization | Depletion Lys | 9.7 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=340; Record_ID=skin_sensitization_invitro_109; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5032523; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=9.6999999999999993; Reported_Response_Unit=%; Response=9.7; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 50 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=342; Record_ID=skin_sensitization_invitro_109; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5032523; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=50; Reported_Response_Unit=%; Response=50; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 53.7 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=349; Record_ID=skin_sensitization_invitro_111; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5032523; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=53.7; Reported_Response_Unit=%; Response=53.7; Response_Unit=%; Reference=Gerberick et al. 2007; 15254333; 10.1093/toxsci/kfh213|Jaworska 2011; 23670904; 10.1002/jat.2869|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
| NTP ICE skin sensitization | EC1.5 | 3.156 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=8781; Record_ID=skin_sensitization_invitro_2433; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID5032523; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=3.1560000000000001; Reported_Response_Unit=uM; Response=3.156; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
| NTP ICE skin sensitization | EC3 | 2.3 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13589; Record_ID=skin_sensitization_invivo_3816; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID5032523; Assay=LLNA; Endpoint=EC3; Response=2.3; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
| NTP ICE skin sensitization | EC3 | 4.8 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13610; Record_ID=skin_sensitization_invivo_3846; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID5032523; Assay=LLNA; Endpoint=EC3; Response=4.8; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Botham et al. 1991; 1782769; 10.1111/j.1600-0536.1991.tb01823.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
| NTP ICE skin sensitization | EC3 | 14.773 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=8782; Record_ID=skin_sensitization_invitro_2433; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID5032523; Assay=KeratinoSens; Endpoint=EC3; Reported_Response=14.773; Reported_Response_Unit=uM; Response=14.773; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
| NTP ICE skin sensitization | EC3 | 32.4 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13599; Record_ID=skin_sensitization_invivo_3826; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID5032523; Assay=LLNA; Endpoint=EC3; Response=32.4; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Botham et al. 1991; 1782769; 10.1111/j.1600-0536.1991.tb01823.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
| NTP ICE skin sensitization | GHS Classification | 1 | unitless | Guinea pig | Dermal | - | In Vivo; SkinSensitization6pack; Guinea Pig Maximization/Buehler | sheet=Data_invivo; excel_row=1401; Record_ID=skin_sensitization_invivo_432; Data_Type=In Vivo; Internal_Data_Source=SkinSensitization6pack; Formulation_ID=MIX518; Formulation_Name=Troysan 680; Percent_Active_Ingredient=10.4; Mixture=Mixture; DTXSID=DTXSID5032523; Assay=Guinea Pig Maximization/Buehler; Endpoint=GHS Classification; Response=1; Response_Unit=Unitless; Species=Guinea pig; Route=Dermal; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
| NTP ICE skin sensitization | IC50 | 50.87 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=8783; Record_ID=skin_sensitization_invitro_2433; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID5032523; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=50.87; Reported_Response_Unit=uM; Response=50.87; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
| NTP ICE skin sensitization | Imax | 23.96 | ratio | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=8784; Record_ID=skin_sensitization_invitro_2433; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID5032523; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=23.96; Reported_Response_Unit=Unitless; Response=23.96; Response_Unit=Ratio; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5032523 |
SCCNFP Opinion 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCNFP Opinion | NOAEL | =10 | mg/kg/day | - | dermal | Sub-chronic | repeated dose toxicity | p.8 |
| SCCNFP Opinion | NOAEL | =15 | mg/kg/day | rat | oral | Sub-chronic | repeated dose toxicity | p.8 |
SCCS Opinion 10 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCS Opinion | NOAEL | =0.018 | mg/kg bw/d | rat | oral | - | dermal absorption | p.26 |
| SCCS Opinion | NOAEL | =8.42 | mg/kg bw/day | rat | oral | subacute | repeated dose toxicity | p.27 |
| SCCS Opinion | NOAEL | =10 | mg/kg bw/day | - | - | Chronic | genotoxicity | p.20 |
| SCCS Opinion | NOAEL | =15 | mg/kg bw/day | rat | oral | Sub-chronic | repeated dose toxicity | p.19 |
| SCCS Opinion | NOAEL | =24 | mg/kg bw/day | - | - | - | genotoxicity | p.27 |
| SCCS Opinion | NOAEL | =25 | - | - | oral | 90-day | reproductive toxicity | p.25 |
| SCCS Opinion | NOAEL | =25 | mg/kg bw/d | rat | oral | - | dermal absorption | p.26 |
| SCCS Opinion | NOAEL | =50 | % | rat | oral | - | dermal absorption | p.26 |
| SCCS Opinion | NOAEL | =1482 | - | - | oral | 90-day | reproductive toxicity | p.25 |
| SCCS Opinion | NOAEL | =4115 | mg/kg bw | rat | oral | subacute | repeated dose toxicity | p.27 |
EPA ToxRefDB v3 15 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA ToxRefDB v3 | LEL | =10 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 0 day to 92 day | SUB | study_id=6071; toxval_study_source_id=studyid6071_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-stomach-thickened|in life observation-clinical signs-oral discharge|in life observation-clinical signs-body temperature|in life observation-mortality-mortality|in life observation-clinical signs-defecation|clinical chemistry-albumin-albumin|clinical chemistry-globulins-globulins|clinical chemistry-protein-protein|in life observation-clinical signs-reduced activity|pathology gross-stomach-discolored|pathology microscopic-stomach-inflammation|in life observation-clinical signs-body surface staining|pathology microscopic-stomach-ulcer|pathology microscopic-larynx-necrosis|in life observation-clinical signs-abnormal respiratory sounds|pathology gross-stomach-distended|pathology microscopic-stomach-hemorrhage|pathology microscopic-trachea-necrosis|in life observation-body weight-body weight gain; dose_level=1; study_year=2007; study_citation=Roper, J. 2007. A 90-day oral (gavage) study of 1,2-benzisothiazolin-3-one in rats. WIL Research Labs, LLC, Report no. 06RC-075. MRID 47759801.; dsstox_substance_id=DTXSID5032523; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =40 | mg/kg bw/day | rat (sprague dawley; Alpk: APfSD) | oral | 7 GD to 16 GD | DEV | study_id=6576; toxval_study_source_id=studyid6576_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-abnormal respiratory sounds|in life observation-food consumption-food consumption|pathology gross-stomach-irregular surface|in life observation-body weight-body weight gain; dose_level=2; study_year=1988; study_citation=Pigott GH and ME Burt. (1988) PROXEL Press Paste: Teratology Study in the Rat. Zeneca, Study No CTL/P/2297. MRID 40961201.; dsstox_substance_id=DTXSID5032523; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =50 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 70 days (premating) to 2 generation | MGR | study_id=6075; toxval_study_source_id=studyid6075_Juvenile_F1_F_developmental; toxval_effect_list=offspring survival late-viability index-viability index; dose_level=3; study_year=2007; study_citation=Stump, DG. 2007. An oral (gavage) two-generation reproductive toxicity study of 1,2-benzisothiazolin-3-one in rats. WIL Research Labs, LLC, Ashland, OH. Lab. project no. WIL-91028. Unpubished report.; dsstox_substance_id=DTXSID5032523; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =69 | mg/kg bw/day | rat (sprague dawley; Alpk: APSD) | oral | 0 week to 13 week | SUB | study_id=6069; toxval_study_source_id=studyid6069_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight|pathology microscopic-stomach-hyperplasia|pathology gross-stomach-thickened|in life observation-food consumption-food efficiency; dose_level=2; study_year=1990; study_citation=Whiles, AJ. 1990. PROXEL Press Paste: 90-day feeding study in rats. ICI Central Tox Lab., Study no. PR0798. MRID 41910401.; dsstox_substance_id=DTXSID5032523; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =89 | mg/kg bw/day | dog (beagle; beagle) | oral | 0 day to 90 day | SUB | study_id=6072; toxval_study_source_id=studyid6072_Adult_F0_F_systemic; toxval_effect_list=in life observation-food consumption-food consumption|in life observation-body weight-body weight gain|in life observation-body weight-body weight; dose_level=3; study_year=2007; study_citation=Roper, JM. 2007. A 90-day dietary toxicity study of 1,2 Benzisothiazolin-3-one in Beagle dogs. WIL Research Labs, LLC, Lab report no. WIL-91030. MRID 47759802.; dsstox_substance_id=DTXSID5032523; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =106 | mg/kg bw/day | dog (beagle; beagle) | oral | 0 day to 90 day | SUB | study_id=6072; toxval_study_source_id=studyid6072_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-body weight-body weight gain|in life observation-food consumption-food consumption; dose_level=3; study_year=2007; study_citation=Roper, JM. 2007. A 90-day dietary toxicity study of 1,2 Benzisothiazolin-3-one in Beagle dogs. WIL Research Labs, LLC, Lab report no. WIL-91030. MRID 47759802.; dsstox_substance_id=DTXSID5032523; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =356 | mg/kg bw/day | rat (sprague dawley; Alpk: APSD) | oral | 0 week to 13 week | SUB | study_id=6069; toxval_study_source_id=studyid6069_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|pathology microscopic-stomach-hyperplasia|pathology microscopic-stomach-infiltration cellular|pathology gross-stomach-thickened; dose_level=3; study_year=1990; study_citation=Whiles, AJ. 1990. PROXEL Press Paste: 90-day feeding study in rats. ICI Central Tox Lab., Study no. PR0798. MRID 41910401.; dsstox_substance_id=DTXSID5032523; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =100 | mg/kg bw/day | rat (sprague dawley; Alpk: APfSD) | oral | 7 GD to 16 GD | DEV | study_id=6576; toxval_study_source_id=studyid6576_Adult_F0_F_systemic; toxval_effect_list=in life observation-food consumption-food consumption|in life observation-body weight-body weight gain; dose_level=3; study_year=1988; study_citation=Pigott GH and ME Burt. (1988) PROXEL Press Paste: Teratology Study in the Rat. Zeneca, Study No CTL/P/2297. MRID 40961201.; dsstox_substance_id=DTXSID5032523; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | >0 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 0 day to 92 day | SUB | study_id=6071; toxval_study_source_id=studyid6071_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-reduced activity|pathology gross-stomach-discolored|pathology microscopic-stomach-ulcer|pathology microscopic-larynx-necrosis|in life observation-clinical signs-abnormal respiratory sounds|pathology microscopic-stomach-inflammation|in life observation-clinical signs-body surface staining|pathology gross-stomach-distended|in life observation-body weight-body weight gain|pathology microscopic-stomach-hemorrhage|pathology microscopic-trachea-necrosis|in life observation-clinical signs-oral discharge|pathology microscopic-stomach-thickened|in life observation-clinical signs-body temperature|in life observation-clinical signs-defecation|clinical chemistry-albumin-albumin|in life observation-mortality-mortality|clinical chemistry-globulins-globulins|clinical chemistry-protein-protein; dose_level=0; study_year=2007; study_citation=Roper, J. 2007. A 90-day oral (gavage) study of 1,2-benzisothiazolin-3-one in rats. WIL Research Labs, LLC, Report no. 06RC-075. MRID 47759801.; dsstox_substance_id=DTXSID5032523; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =10 | mg/kg bw/day | rat (sprague dawley; Alpk: APfSD) | oral | 7 GD to 16 GD | DEV | study_id=6576; toxval_study_source_id=studyid6576_Adult_F0_F_systemic; toxval_effect_list=pathology gross-stomach-irregular surface|in life observation-food consumption-food consumption|in life observation-clinical signs-abnormal respiratory sounds|in life observation-body weight-body weight gain; dose_level=1; study_year=1988; study_citation=Pigott GH and ME Burt. (1988) PROXEL Press Paste: Teratology Study in the Rat. Zeneca, Study No CTL/P/2297. MRID 40961201.; dsstox_substance_id=DTXSID5032523; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =15.3 | mg/kg bw/day | rat (sprague dawley; Alpk: APSD) | oral | 0 week to 13 week | SUB | study_id=6069; toxval_study_source_id=studyid6069_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight|pathology microscopic-stomach-hyperplasia|pathology gross-stomach-thickened|in life observation-food consumption-food efficiency; dose_level=1; study_year=1990; study_citation=Whiles, AJ. 1990. PROXEL Press Paste: 90-day feeding study in rats. ICI Central Tox Lab., Study no. PR0798. MRID 41910401.; dsstox_substance_id=DTXSID5032523; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =25 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 70 days (premating) to 2 generation | MGR | study_id=6075; toxval_study_source_id=studyid6075_Juvenile_F1_F_developmental; toxval_effect_list=offspring survival late-viability index-viability index; dose_level=2; study_year=2007; study_citation=Stump, DG. 2007. An oral (gavage) two-generation reproductive toxicity study of 1,2-benzisothiazolin-3-one in rats. WIL Research Labs, LLC, Ashland, OH. Lab. project no. WIL-91028. Unpubished report.; dsstox_substance_id=DTXSID5032523; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =37 | mg/kg bw/day | dog (beagle; beagle) | oral | 0 day to 90 day | SUB | study_id=6072; toxval_study_source_id=studyid6072_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-food consumption-food consumption|in life observation-body weight-body weight gain; dose_level=2; study_year=2007; study_citation=Roper, JM. 2007. A 90-day dietary toxicity study of 1,2 Benzisothiazolin-3-one in Beagle dogs. WIL Research Labs, LLC, Lab report no. WIL-91030. MRID 47759802.; dsstox_substance_id=DTXSID5032523; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =38 | mg/kg bw/day | dog (beagle; beagle) | oral | 0 day to 90 day | SUB | study_id=6072; toxval_study_source_id=studyid6072_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-body weight-body weight gain|in life observation-food consumption-food consumption; dose_level=2; study_year=2007; study_citation=Roper, JM. 2007. A 90-day dietary toxicity study of 1,2 Benzisothiazolin-3-one in Beagle dogs. WIL Research Labs, LLC, Lab report no. WIL-91030. MRID 47759802.; dsstox_substance_id=DTXSID5032523; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =78.3 | mg/kg bw/day | rat (sprague dawley; Alpk: APSD) | oral | 0 week to 13 week | SUB | study_id=6069; toxval_study_source_id=studyid6069_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|pathology microscopic-stomach-hyperplasia|pathology gross-stomach-thickened|pathology microscopic-stomach-infiltration cellular; dose_level=2; study_year=1990; study_citation=Whiles, AJ. 1990. PROXEL Press Paste: 90-day feeding study in rats. ICI Central Tox Lab., Study no. PR0798. MRID 41910401.; dsstox_substance_id=DTXSID5032523; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ECHA 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEL | =20 | mg/kg bw/day | Dog | oral | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadf8e4b0a7c65d1c6cbe; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22961/7/6/2?documentUUID=edfd03d9-4515-43bd-aa36-0223d7a8ece1; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=clinical signs; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15836433_15849349:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f214ba958b12eb0a98f468c1f4e5b1ee |
| ECHA | NOAEL | =5 | mg/kg bw/day | Dog | oral | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadf8e4b0a7c65d1c6cbe; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22961/7/6/2?documentUUID=edfd03d9-4515-43bd-aa36-0223d7a8ece1; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=clinical signs; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15836433_15849349:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ea6ab1171f9dcdf5e373eeafe3392b94 |
| ECHA | NOAEL | =56.6 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaadfe4b0a7c65d1b7d03; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22961/7/9/2?documentUUID=edfd03d9-4515-43bd-aa36-0223d7a8ece1; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=F2: viability|F2: body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|reproduction; STUDY_GROUP=ECHA IUCLID:15862763:M/F:F2-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_87ffe7c66585c4b95a3d807ede2791e7 |
| ECHA | NOAEL | =69 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadf9e4b0a7c65d1c6cc4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22961/7/6/2?documentUUID=edfd03d9-4515-43bd-aa36-0223d7a8ece1; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=body weight and weight gain|food consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECHA IUCLID:15849350:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_18877f03565ee937984a2b480226a79c |
| ECHA | NOAEL | =112 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaadfe4b0a7c65d1b7d03; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22961/7/9/2?documentUUID=edfd03d9-4515-43bd-aa36-0223d7a8ece1; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=P0: clinical signs|P0: body weight and weight gain | P0: reproductive function (oestrouscycle) | P0: reproductivefunction (sperm measures) | P0: reproductive performance; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|reproduction; STUDY_GROUP=ECHA IUCLID:15860717:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6387bfecb94261513079bbeb69fbbbb6 |
| ECHA | NOAEL | =150 | mg/kg bw/day | Rat | oral | short-term; 4 weeks | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadf8e4b0a7c65d1c6cbb; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22961/7/6/2?documentUUID=edfd03d9-4515-43bd-aa36-0223d7a8ece1; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID:15849348:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_82a1b461457388ec3f7d012a0c9f6c43 |
ToxValDB ECOTOX 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =100 | ppm | Rat | oral | acute; 0.0417 days | acute | LONG_REF=Pharmacol. Res. Commun.3(4): 385-400 Bertaccini,G., M. Impicciatore, and T. Vitali Pharmacological Activities of Benzisothiazolone and Benzisoxazolone 1971; TITLE=Pharmacological Activities of Benzisothiazolone and Benzisoxazolone; AUTHOR=Bertaccini,G., M. Impicciatore, and T. Vitali; DOI=10.1016/0031-6989(71)90011-7; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=81165; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1971; ORIGINAL_YEAR=1971; TOXICOLOGICAL_EFFECT=Behavior: Response time to a stimulus; TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=ECOTOX:15601058:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7cba0641f0a0e957b153d210d9878316 |
| ToxValDB ECOTOX | NOEL | =90 | mg/kg bw/day | Rat | oral | acute; 0.5 days | acute | LONG_REF=J. Occup. Health40(3): 198-202 Hellman,B., M. Sjoquist, H. Anundi, and C. Edling No Evidence for a Diuretic Effect of Benzisothiazolinone (BIT) in an Experimental Animal Model Employing Anaesthetised Rats 1998; TITLE=No Evidence for a Diuretic Effect of Benzisothiazolinone (BIT) in an Experimental Animal Model Employing Anaesthetised Rats; AUTHOR=Hellman,B., M. Sjoquist, H. Anundi, and C. Edling; DOI=10.1539/joh.40.198; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=81347; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Physiology: Blood pressure; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX:15605080:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d37b4d74acffe72e6d764bb33158925e |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =6.81 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630018:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c0e6f0fbad8a1d0fe950ce2507e2ac4e |
ToxValDB ToxRefDB 13 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ToxRefDB | LEL | =10 | mg/kg bw/day | Rat | oral | chronic; 92 days | chronic | LONG_REF=Roper, J. 2007. A 90-day oral (gavage) study of 1,2-benzisothiazolin-3-one in rats. WIL Research Labs, LLC, Report no. 06RC-075. MRID 47759801.; TITLE=A 90-day oral (gavage) study of 1,2-benzisothiazolin-3-one in rats; AUTHOR=Roper, J; EXTERNAL_SOURCE_ID=6071; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-stomach-thickened|systemic: in life observation-mortality-mortality|systemic: in life observation-clinical signs-oral discharge|systemic: pathology gross-stomach-distended|systemic: in life observation-clinical signs-reduced activity|systemic: in life observation-clinical signs-defecation|systemic: clinical chemistry-albumin-albumin|systemic: pathology gross-stomach-discolored|systemic: pathology microscopic-stomach-inflammation|systemic: pathology microscopic-stomach-hemorrhage|systemic: in life observation-clinical signs-body surface staining|systemic: pathology microscopic-trachea-necrosis|systemic: in life observation-clinical signs-body temperature|systemic: pathology microscopic-stomach-ulcer|systemic: in life observation-body weight-body weight gain|systemic: clinical chemistry-globulins-globulins|systemic: pathology microscopic-larynx-necrosis|systemic: in life observation-clinical signs-abnormal respiratory sounds|systemic: clinical chemistry-protein-protein; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|gross pathology|mortality/survival|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15710800_15710801:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7bd870ef41a994e776fd0ec25ef30e62 |
| ToxValDB ToxRefDB | LEL | =40 | mg/kg bw/day | Rat | oral | short-term (developmental); 10 days | reproduction developmental | LONG_REF=Pigott GH and ME Burt. (1988) PROXEL Press Paste: Teratology Study in the Rat. Zeneca, Study No CTL/P/2297. MRID 40961201.; TITLE=PROXEL Press Paste: Teratology Study in the Rat; AUTHOR=Pigott GH and ME Burt; EXTERNAL_SOURCE_ID=6576; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-abnormal respiratory sounds|systemic: pathology gross-stomach-irregular surface|systemic: in life observation-body weight-body weight gain|systemic: in life observation-food consumption-food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|gross pathology; STUDY_GROUP=ToxRefDB_dup_-_15712300_15712301_15712302_15712303:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_969be76c7e1c9b0a904398eac5cce653 |
| ToxValDB ToxRefDB | LEL | =50 | mg/kg bw/day | Rat | oral | chronic (developmental) | developmental | LONG_REF=Stump, DG. 2007. An oral (gavage) two-generation reproductive toxicity study of 1,2-benzisothiazolin-3-one in rats. WIL Research Labs, LLC, Ashland, OH. Lab. project no. WIL-91028. Unpubished report.; TITLE=An oral (gavage) two-generation reproductive toxicity study of 1,2-benzisothiazolin-3-one in rats; AUTHOR=Stump, DG; EXTERNAL_SOURCE_ID=6075; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=developmental: offspring survival late-viability index-viability index; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ToxRefDB_dup_-_15710820_15710821_15710822_15710823:F:F1juvenile; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5c4b04b2387b82136de708a53377f1b0 |
| ToxValDB ToxRefDB | LEL | =89 | mg/kg bw/day | Dog | oral | subchronic; 90 days | subchronic | LONG_REF=Roper, JM. 2007. A 90-day dietary toxicity study of 1,2 Benzisothiazolin-3-one in Beagle dogs. WIL Research Labs, LLC, Lab report no. WIL-91030. MRID 47759802.; TITLE=A 90-day dietary toxicity study of 1,2 Benzisothiazolin-3-one in Beagle dogs; AUTHOR=Roper, JM; EXTERNAL_SOURCE_ID=6072; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain|systemic: in life observation-food consumption-food consumption|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15710804_15710805_15710806_15710807:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3c2d9f6af702bd2eff768891363d83a4 |
| ToxValDB ToxRefDB | LEL | =106 | mg/kg bw/day | Dog | oral | subchronic; 90 days | subchronic | LONG_REF=Roper, JM. 2007. A 90-day dietary toxicity study of 1,2 Benzisothiazolin-3-one in Beagle dogs. WIL Research Labs, LLC, Lab report no. WIL-91030. MRID 47759802.; TITLE=A 90-day dietary toxicity study of 1,2 Benzisothiazolin-3-one in Beagle dogs; AUTHOR=Roper, JM; EXTERNAL_SOURCE_ID=6072; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: in life observation-body weight-body weight gain|systemic: in life observation-food consumption-food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15710808_15710809_15710810_15710811:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6e5e1cd9623443eb7ca7fde845f543e8 |
| ToxValDB ToxRefDB | LEL | =356 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=Whiles, AJ. 1990. PROXEL Press Paste: 90-day feeding study in rats. ICI Central Tox Lab., Study no. PR0798. MRID 41910401.; TITLE=PROXEL Press Paste: 90-day feeding study in rats; AUTHOR=Whiles, AJ; EXTERNAL_SOURCE_ID=6069; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-stomach-infiltration cellular|systemic: pathology gross-stomach-thickened|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-stomach-hyperplasia; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|gross pathology|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15710792_15710793_15710794_15710795:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_79d232c08b593acb5cb207d0c58b206f |
| ToxValDB ToxRefDB | LOAEL | =100 | mg/kg bw/day | Rat | oral | short-term (developmental); 10 days | reproduction developmental | LONG_REF=Pigott GH and ME Burt. (1988) PROXEL Press Paste: Teratology Study in the Rat. Zeneca, Study No CTL/P/2297. MRID 40961201.; TITLE=PROXEL Press Paste: Teratology Study in the Rat; AUTHOR=Pigott GH and ME Burt; EXTERNAL_SOURCE_ID=6576; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain|systemic: in life observation-food consumption-food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15712300_15712301_15712302_15712303:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6324ff093da611af743114836ea6c630 |
| ToxValDB ToxRefDB | NEL | =10 | mg/kg bw/day | Rat | oral | short-term (developmental); 10 days | developmental | LONG_REF=Pigott GH and ME Burt. (1988) PROXEL Press Paste: Teratology Study in the Rat. Zeneca, Study No CTL/P/2297. MRID 40961201.; TITLE=PROXEL Press Paste: Teratology Study in the Rat; AUTHOR=Pigott GH and ME Burt; EXTERNAL_SOURCE_ID=6576; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=developmental: developmental malformation-bone-unossified|developmental: developmental malformation-bone-incomplete ossification; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ToxRefDB_dup_-_15712304_15712305_15712306_15712307:M/F:fetusfetal; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8427ad6aab62bcaec0f3434079d75a59 |
| ToxValDB ToxRefDB | NEL | =15.3 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=Whiles, AJ. 1990. PROXEL Press Paste: 90-day feeding study in rats. ICI Central Tox Lab., Study no. PR0798. MRID 41910401.; TITLE=PROXEL Press Paste: 90-day feeding study in rats; AUTHOR=Whiles, AJ; EXTERNAL_SOURCE_ID=6069; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=systemic: pathology gross-stomach-thickened|systemic: in life observation-food consumption-food efficiency|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-stomach-hyperplasia; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|gross pathology|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15710796_15710797_15710798_15710799:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_616a941e67ca4f912aa8e6a3cd155377 |
| ToxValDB ToxRefDB | NEL | =25 | mg/kg bw/day | Rat | oral | chronic (developmental) | developmental | LONG_REF=Stump, DG. 2007. An oral (gavage) two-generation reproductive toxicity study of 1,2-benzisothiazolin-3-one in rats. WIL Research Labs, LLC, Ashland, OH. Lab. project no. WIL-91028. Unpubished report.; TITLE=An oral (gavage) two-generation reproductive toxicity study of 1,2-benzisothiazolin-3-one in rats; AUTHOR=Stump, DG; EXTERNAL_SOURCE_ID=6075; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=developmental: offspring survival late-viability index-viability index; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ToxRefDB_dup_-_15710820_15710821_15710822_15710823:F:F1juvenile; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_72c0c856f5a99173bb6c6d9a41a0f0c2 |
| ToxValDB ToxRefDB | NEL | =37 | mg/kg bw/day | Dog | oral | subchronic; 90 days | subchronic | LONG_REF=Roper, JM. 2007. A 90-day dietary toxicity study of 1,2 Benzisothiazolin-3-one in Beagle dogs. WIL Research Labs, LLC, Lab report no. WIL-91030. MRID 47759802.; TITLE=A 90-day dietary toxicity study of 1,2 Benzisothiazolin-3-one in Beagle dogs; AUTHOR=Roper, JM; EXTERNAL_SOURCE_ID=6072; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=systemic: in life observation-food consumption-food consumption|systemic: in life observation-body weight-body weight gain|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15710808_15710809_15710810_15710811:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1c3cce0c8aa5ff929341e66395335a4d |
| ToxValDB ToxRefDB | NEL | =38 | mg/kg bw/day | Dog | oral | subchronic; 90 days | subchronic | LONG_REF=Roper, JM. 2007. A 90-day dietary toxicity study of 1,2 Benzisothiazolin-3-one in Beagle dogs. WIL Research Labs, LLC, Lab report no. WIL-91030. MRID 47759802.; TITLE=A 90-day dietary toxicity study of 1,2 Benzisothiazolin-3-one in Beagle dogs; AUTHOR=Roper, JM; EXTERNAL_SOURCE_ID=6072; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=systemic: in life observation-food consumption-food consumption|systemic: in life observation-body weight-body weight|systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15710804_15710805_15710806_15710807:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_04d6dd7e4cf4dab9a20f62fbfa14aeb8 |
| ToxValDB ToxRefDB | NEL | =78.3 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=Whiles, AJ. 1990. PROXEL Press Paste: 90-day feeding study in rats. ICI Central Tox Lab., Study no. PR0798. MRID 41910401.; TITLE=PROXEL Press Paste: 90-day feeding study in rats; AUTHOR=Whiles, AJ; EXTERNAL_SOURCE_ID=6069; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: pathology microscopic-stomach-hyperplasia|systemic: pathology gross-stomach-thickened|systemic: pathology microscopic-stomach-infiltration cellular; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|gross pathology|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15710792_15710793_15710794_15710795:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_df0405b7dc6d5646458f3adc1e0ce248 |
Regulatory source 14 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | developmental toxicity | 10 | mg/kg/day | rat | - | 90 day | developmental toxicity | p.19 |
| Regulatory source | repeated dose toxicity | 10 | mg/kg/day | - | dermal | Sub-chronic | repeated dose toxicity | p.8 |
| Regulatory source | repeated dose toxicity | 15 | mg/kg/day | rat | oral | Sub-chronic | repeated dose toxicity | p.8 |
| Regulatory source | dermal absorption | =0.018 | mg/kg bw/d | rat | oral | - | dermal absorption | p.26 |
| Regulatory source | dermal absorption | =25 | mg/kg bw/d | rat | oral | - | dermal absorption | p.26 |
| Regulatory source | dermal absorption | 50 | % | rat | oral | - | dermal absorption | p.26 |
| Regulatory source | genotoxicity | 10 | mg/kg bw/day | - | - | Chronic | genotoxicity | p.20 |
| Regulatory source | genotoxicity | 24 | mg/kg bw/day | - | - | - | genotoxicity | p.27 |
| Regulatory source | genotoxicity | 24 | mg/kg bw/day | rat | - | - | genotoxicity | p.27 |
| Regulatory source | repeated dose toxicity | 8.42 | mg/kg bw/day | rat | oral | subacute | repeated dose toxicity | p.27 |
| Regulatory source | repeated dose toxicity | 15 | mg/kg bw/day | rat | oral | Sub-chronic | repeated dose toxicity | p.19 |
| Regulatory source | repeated dose toxicity | 4115 | mg/kg bw | rat | oral | subacute | repeated dose toxicity | p.27 |
| Regulatory source | reproductive toxicity | 25 | - | - | oral | 90-day | reproductive toxicity | p.25 |
| Regulatory source | reproductive toxicity | 1482 | - | - | oral | 90-day | reproductive toxicity | p.25 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | HRA0F1A4R3 | UNII | - | - | - | chemical | - |