NOAEL Studies
Preservative
Benzoic Acid NOAEL Studies
INCI: BENZOIC ACID
CAS: 65-85-0
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS DB 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | LOAEL | 25 | mg/kg bw/day | rat | oral | 5-16 Gestation day | Developmental | PAFA; SBJ |
| COSMOS DB | NOAEL | 25 | mg/kg bw/day | rat | oral | 10 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 80 | mg/kg bw/day | mouse | oral | 240 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 175 | mg/kg bw/day | mouse | oral | 10 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 250 | mg/kg bw/day | rabbit | oral | 13 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 300 | mg/kg bw/day | hamster | oral | 5 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
EFSA 11 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA | NOAEL | =500 | mg/kg bw/day | Rat | oral: feed | 730 days | chronic/long term toxicity | EFSA - 2016 - OutputID 2899 - other - systemic - Peer review of the pesticide risk assessment of the active substance benzoic acid - doi:10.2903/j.efsa.2016.4657 |
| EFSA | NOAEL | =1310 | mg/kg bw/day | Rat | oral: feed | - | reproduction toxicity | EFSA ANS - 2016 - OutputID 2794 - no adverse effect observed at single/highest dose - Scientific Opinion on the re-evaluation of benzoic acid (E 210), sodium benzoate (E 211), potassium benzoate (E 212) and calcium benzoate (E 213) as food additives - doi:10.2903/j.efsa.2016.4433 |
| EFSA | ADI | =5 | mg/kg bw/day | Consumers | - | - | ADI | EFSA - 2016 - OutputID 2899 - Consumers - Peer review of the pesticide risk assessment of the active substance benzoic acid - doi:10.2903/j.efsa.2016.4657 |
| EFSA | ADI | =300 | mg/person/day | Consumers | - | - | ADI | EFSA FEEDAP - 2012 - OutputID 246 - Consumers - Scientific Opinion on safety and efficacy of CRINA Poultry Plus (preparation of benzoic acid and essential oil compounds) as feed additive for chickens for fattening - doi:10.2903/j.efsa.2012.2620 |
| EFSA | ADI (group) | =5 | mg/kg bw/day | Consumers | - | - | ADI (group) | EFSA ANS - 2016 - OutputID 2794 - Consumers - Scientific Opinion on the re-evaluation of benzoic acid (E 210), sodium benzoate (E 211), potassium benzoate (E 212) and calcium benzoate (E 213) as food additives - doi:10.2903/j.efsa.2016.4433 |
| EFSA | LEL | =1500 | mg/kg bw/day | Chicken | oral | subchronic; 36 days | subchronic | LONG_REF=EFSA FEEDAP (2018). Safety and efficacy of benzoic acid for pigs and poultry. doi:10.2903/j.efsa.2018.5210.; TITLE=Safety and efficacy of benzoic acid for pigs and poultry; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2018.5210; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2018; ORIGINAL_YEAR=2018; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15614187:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1cf7ce6c1ead0cde1795647f52dadd6c |
| EFSA | LEL | =5000 | mg/kg bw/day | Pig | oral | subchronic; 42 days | subchronic | LONG_REF=EFSA FEEDAP (2018). Safety and efficacy of benzoic acid for pigs and poultry. doi:10.2903/j.efsa.2018.5210.; TITLE=Safety and efficacy of benzoic acid for pigs and poultry; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2018.5210; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2018; ORIGINAL_YEAR=2018; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15614186:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b04b93ba97b94befa6d1291eeb08949c |
| EFSA | LEL | =10000 | mg/kg bw/day | Pig | oral | - | repeat dose other | LONG_REF=EFSA FEEDAP (2005). Opinion of the Scientific Panel on Additives and Products or Substances used in Animal Feed on the safety and efficacy of the product VevoVitall as a feed additive for weaned piglets in accordance with Regulation (EC) No 1831/2003. doi:10.2903/j.efsa.2005.290.; TITLE=Opinion of the Scientific Panel on Additives and Products or Substances used in Animal Feed on the safety and efficacy of the product VevoVitall as a feed additive for weaned piglets in accordance with Regulation (EC) No 1831/2003; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2005.290; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=histopathology: nonneoplastic; STUDY_GROUP=EFSA_dup_-_15614171_15614172:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0dea15e2a1074e82305f90c52fc3f1da |
| EFSA | LEL | =20000 | mg/kg bw/day | Pig | oral | subchronic; 84 days | subchronic | LONG_REF=EFSA FEEDAP (2007). Opinion of the Scientific Panel on Additives and Products or Substances used in Animal Feed on the safety and efficacy of VevoVitall (benzoic acid) as feed additive for pigs for fattening. doi:10.2903/j.efsa.2007.457.; TITLE=Opinion of the Scientific Panel on Additives and Products or Substances used in Animal Feed on the safety and efficacy of VevoVitall (benzoic acid) as feed additive for pigs for fattening; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2007.457; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=organ weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=EFSA:15614173:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e980ceb23c80cfdc58b213cb86d028e7 |
| EFSA | NOAEL | =500 | mg/kg bw/day | Rat | oral | chronic; 16 weeks | chronic | LONG_REF=EFSA (2016). Peer review of the pesticide risk assessment of the active substance benzoic acid. doi:10.2903/j.efsa.2016.4657.; TITLE=Peer review of the pesticide risk assessment of the active substance benzoic acid; AUTHOR=EFSA; DOI=doi:10.2903/j.efsa.2016.4657; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=histopathology: nonneoplastic; STUDY_GROUP=EFSA:15614181:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a4356e33e211cbee405942b7f8f699e3 |
| EFSA | NOAEL | =1310 | mg/kg bw/day | Rat | oral | - | reproduction developmental | LONG_REF=EFSA ANS (2016). Scientific Opinion on the re-evaluation of benzoic acid (E 210), sodium benzoate (E 211), potassium benzoate (E 212) and calcium benzoate (E 213) as food additives. doi:10.2903/j.efsa.2016.4433.; TITLE=Scientific Opinion on the re-evaluation of benzoic acid (E 210), sodium benzoate (E 211), potassium benzoate (E 212) and calcium benzoate (E 213) as food additives; AUTHOR=EFSA ANS; DOI=doi:10.2903/j.efsa.2016.4433; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15614175:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9a1999b2b3aebec7d35a2d4c6ddb626e |
Regulatory source 17 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | NOAEL | =4.4 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system PoD | row_hash=bca8fc84025ed602; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=NOAEL : 4.4 mg/kg-day; system=Other; basis=No adverse effects observed; point_of_departure=NOAEL : 4.4 mg/kg-day; composite_uf=1; confidence=Medium; dtxsid=DTXSID6020143; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=355; rfd_last_updated=09/07/1988; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0355_summary.pdf |
| Regulatory source | RfD | =4 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system | row_hash=db9403bf0c77df73; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=4; system=Other; basis=No adverse effects observed; point_of_departure=NOAEL : 4.4 mg/kg-day; composite_uf=1; confidence=Medium; dtxsid=DTXSID6020143; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=355; rfd_last_updated=09/07/1988; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0355_summary.pdf |
| Regulatory source | - | 4 | % | rat | oral | 90 days | - | p.8 |
| Regulatory source | - | 175 | mg/kg bw | rat | - | - | - | p.12 |
| Regulatory source | - | 250 | mg/kg bw | rat | - | - | - | p.12 |
| Regulatory source | - | 250 | mg/kg bw | rabbit | - | - | - | p.12 |
| Regulatory source | - | 300 | mg/kg bw | rat | - | - | - | p.12 |
| Regulatory source | - | 300 | mg/kg bw | - | - | - | - | p.12 |
| Regulatory source | - | 1000 | mg/kg bw/d | rat | intravenous | 16 months | - | p.15 |
| Regulatory source | dermal absorption | 500 | mg/kg bw | rat | oral | 16 weeks | dermal absorption | p.12 |
| Regulatory source | developmental toxicity | 500 | mg/kg | rat | oral | chronic | developmental toxicity | p.16 |
| Regulatory source | repeated dose toxicity | 300 | mg/kg bw | rat | oral | subacute | repeated dose toxicity | p.16 |
| Regulatory source | - | 175 | mg/kg bw | rat | oral | - | - | p.21 |
| Regulatory source | - | 500 | mg/kg bw | rat | oral | 16 weeks | - | p.21 |
| Regulatory source | - | 500 | mg/kg bw/d | human | - | - | - | p.23 |
| Regulatory source | developmental toxicity | 500 | mg/kg bw/day | - | oral | developmental | developmental toxicity | p.24 |
| Regulatory source | reproductive toxicity | 500 | mg/kg bw/day | - | oral | developmental | reproductive toxicity | p.24 |
WHO/JECFA 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| WHO/JECFA | NOAEL | ~500 | mg/kg bw/day | - | - | - | Reproductive toxicity | document_id=cicads_cicads_cicad26; title=BENZOIC ACID AND SODIUM BENZOATE; path=mirror/documents/cicads/cicads/cicad26.htm; row_hash=7e7bb2f770df14c8; raw_unit=mg/kg body weight per day; context=From a limited four-generation study, only a preliminary no-observed-(adverse-)effect level (NO(A)EL) of about 500 mg/kg body weight per day can be derived. |
| WHO/JECFA | NOAEL | ~1310 | mg/kg bw | Rat | oral | - | Toxicology study | document_id=cicads_cicads_cicad26; title=BENZOIC ACID AND SODIUM BENZOATE; path=mirror/documents/cicads/cicads/cicad26.htm; row_hash=bf42f7715d8d6de5; raw_unit=mg/kg body weight; context=In a dietary study in rats, a NO(A)EL of about 1310 mg/kg body weight was established. |
| WHO/JECFA | NOAEL | ~1310 | mg/kg bw/day | - | - | - | Toxicology study | document_id=cicads_cicads_cicad26; title=BENZOIC ACID AND SODIUM BENZOATE; path=mirror/documents/cicads/cicads/cicad26.htm; row_hash=493f2ff973bfd635; raw_unit=mg/kg body weight per day; context=From this study, a NO(A)EL of about 1310 mg/kg body weight per day can be derived. |
| WHO/JECFA | ADI | <=20 | mg/kg | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650afa11e4b0d99f5a878f74; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/1754; YEAR=2021; ORIGINAL_YEAR=2021; STUDY_GROUP=WHO JECFA ADI:15715339:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_982e23b482dfb8d3e6dba6294c378567 |
NTP ICE acute inhalation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | LC50 | >0.026 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3268; Record_ID=acute_inhalation_2767; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6020143; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=0.026; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020143; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020143 |
NTP ICE acute oral 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =1700 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_8997; row=9900; data_type=In Vivo; mixture=Chemical; chemical_name=Benzoic acid; preferred_name=Benzoic acid; dtxsid=DTXSID6020143; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020143; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6020143; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =2360 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_8998; row=9901; data_type=In Vivo; mixture=Chemical; chemical_name=Benzoic acid; preferred_name=Benzoic acid; dtxsid=DTXSID6020143; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020143; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6020143; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =2565 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_8999; row=9902; data_type=In Vivo; mixture=Chemical; chemical_name=Benzoic acid; preferred_name=Benzoic acid; dtxsid=DTXSID6020143; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020143; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6020143; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =2742 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_9000; row=9899; data_type=In Vivo; mixture=Chemical; chemical_name=Benzoic acid; preferred_name=Benzoic acid; dtxsid=DTXSID6020143; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020143; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6020143; source_file=acute_oral.xlsx |
NTP ICE adme parameters 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE adme parameters | Clint | 0.78 | uL/min/10^6 cells | Rat | - | - | Measured; httk, Rat Hepatic Intrinsic Clearance | sheet=Data; excel_row=2305; Record_ID=adme_parameters_1364; Data_Type=Measured; DTXSID=DTXSID6020143; Assay=httk, Rat Hepatic Intrinsic Clearance; Endpoint=Clint; Response=0.78; Response_Unit=ul/min/10^6 cells; Species=Rat; Reference=httk2.3.1, Honda 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020143; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020143 |
| NTP ICE adme parameters | Fu | 0.422 | fraction | Rat | - | - | Measured; httk, Rat Plasma Fraction Unbound | sheet=Data; excel_row=2306; Record_ID=adme_parameters_1364; Data_Type=Measured; DTXSID=DTXSID6020143; Assay=httk, Rat Plasma Fraction Unbound; Endpoint=Fu; Response=0.422; Response_Unit=Unitless Fraction; Species=Rat; Reference=httk2.3.1, Honda 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020143; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020143 |
NTP ICE endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=5340; RecordID=ARPathway2016_1453; DatasetName=ARPathway2016; DTXSID=DTXSID6020143; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020143; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020143 |
NTP ICE skin sensitization 16 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | CD86, EC150 | >854.861 | ug/mL | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; U-SENS | sheet=Data_invitro; excel_row=8171; Record_ID=skin_sensitization_invitro_2194; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID6020143; Assay=U-SENS; Endpoint=CD86, EC150; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=7000; Reported_Response_Unit=uM; Conversion_Factor_Value=122.123; Conversion_Factor_Source=EPA Dashboard; Converted_Response_Modifier=>; Converted_Response=854.861; Converted_Response_Unit=ug/mL; Response=854.861; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020143; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020143 |
| NTP ICE skin sensitization | CV75 | 1000 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3800; Record_ID=skin_sensitization_invitro_864; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID6020143; Assay=h-CLAT; Endpoint=CV75; Reported_Response=1000; Reported_Response_Unit=ug/mL; Response=1000; Response_Unit=ug/mL; Reference=Ashikaga et al. 2010; 20822320; 10.1177/026119291003800403; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020143; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020143 |
| NTP ICE skin sensitization | Depletion Cys | 16.2 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1464; Record_ID=skin_sensitization_invitro_390; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6020143; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=16.2; Reported_Response_Unit=%; Response=16.2; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020143; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020143 |
| NTP ICE skin sensitization | Depletion Cys | 22.6 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1468; Record_ID=skin_sensitization_invitro_391; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6020143; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=22.6; Reported_Response_Unit=%; Response=22.6; Response_Unit=%; Reference=Jaworska 2011; 23670904; 10.1002/jat.2869; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020143; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020143 |
| NTP ICE skin sensitization | Depletion Lys | 23.4 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1467; Record_ID=skin_sensitization_invitro_391; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6020143; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=23.4; Reported_Response_Unit=%; Response=23.4; Response_Unit=%; Reference=Jaworska 2011; 23670904; 10.1002/jat.2869; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020143; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020143 |
| NTP ICE skin sensitization | Depletion Lys | 68.1 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1463; Record_ID=skin_sensitization_invitro_390; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6020143; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=68.099999999999994; Reported_Response_Unit=%; Response=68.1; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020143; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020143 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 23 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1469; Record_ID=skin_sensitization_invitro_391; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6020143; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=23; Reported_Response_Unit=%; Response=23; Response_Unit=%; Reference=Jaworska 2011; 23670904; 10.1002/jat.2869; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020143; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020143 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 42.2 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1465; Record_ID=skin_sensitization_invitro_390; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6020143; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=42.2; Reported_Response_Unit=%; Response=42.2; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020143; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020143 |
| NTP ICE skin sensitization | EC1.5 | >2000 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6398; Record_ID=skin_sensitization_invitro_1515; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6020143; Assay=KeratinoSens; Endpoint=EC1.5; Response_Modifier=>; Reported_Response=No induction; Reported_Response_Unit=Unitless; Conversion_Factor=Text to numeric; Conversion_Factor_Value=No induction assumed >2000 uM; Conversion_Factor_Source=Manually calculated; Converted_Response_Modifier=>; Converted_Response=2000; Converted_Response_Unit=uM; Response=2000; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020143; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020143 |
| NTP ICE skin sensitization | Imax | 1.1 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6401; Record_ID=skin_sensitization_invitro_1515; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6020143; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.1000000000000001; Reported_Response_Unit=Unitless; Response=1.1; Response_Unit=Ratio; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020143; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020143 |
| NTP ICE skin sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=9284; Record_ID=skin_sensitization_invivo_2055; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6020143; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1977: report to RIFM|Anonymous 1979; Not available; 10.1016/S0015-6264(79)80012-7; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020143; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020143 |
| NTP ICE skin sensitization | Induction dose per skin area | 1350 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=9282; Record_ID=skin_sensitization_invivo_2055; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6020143; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=1350; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1977: report to RIFM|Anonymous 1979; Not available; 10.1016/S0015-6264(79)80012-7; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020143; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020143 |
| NTP ICE skin sensitization | Induction dose per skin area | 3750 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=9290; Record_ID=skin_sensitization_invivo_2057; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6020143; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=3750; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Leyden and Kligman 1977; 145346; 10.1111/j.1600-0536.1977.tb03674.x|Anonymous 1979; Not available; 10.1016/S0015-6264(79)80012-8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020143; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020143 |
| NTP ICE skin sensitization | Relative reliability score | 2 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=9296; Record_ID=skin_sensitization_invivo_2057; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6020143; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=2; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Leyden and Kligman 1977; 145346; 10.1111/j.1600-0536.1977.tb03674.x|Anonymous 1979; Not available; 10.1016/S0015-6264(79)80012-8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020143; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020143 |
| NTP ICE skin sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=9288; Record_ID=skin_sensitization_invivo_2055; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6020143; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1977: report to RIFM|Anonymous 1979; Not available; 10.1016/S0015-6264(79)80012-7; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020143; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020143 |
| NTP ICE skin sensitization | Relative reliability score | 5 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=9303; Record_ID=skin_sensitization_invivo_2059; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Mixture=Chemical; DTXSID=DTXSID6020143; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=5; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Gad et al. 1986; 3715870; 10.1016/0041-008X(86)90419-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020143; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020143 |
SCCNFP Opinion 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCNFP Opinion | NOAEL | =250 | mg/kg bw | rabbit | - | - | NOAEL study | p.12 |
| SCCNFP Opinion | NOAEL | =300 | mg/kg bw | rat | oral | subacute | repeated dose toxicity | p.16 |
| SCCNFP Opinion | NOAEL | =500 | mg/kg bw | rat | oral | 16 weeks | dermal absorption | Ref. : 41 2, p.12 |
| SCCNFP Opinion | NOAEL | =500 | mg/kg | rat | oral | chronic | developmental toxicity | p.16 |
| SCCNFP Opinion | NOAEL | =1000 | mg/kg bw/d | rat | intravenous | 16 months | NOAEL study | Ref. : 42 2, p.15 |
SCCS Opinion 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCS Opinion | NOAEL | =4 | % | rat | oral | 90 days | NOAEL study | p.16 |
| SCCS Opinion | NOAEL | =175 | mg/kg bw | rat | oral | - | NOAEL study | p.21 |
| SCCS Opinion | NOAEL | =250 | mg/kg bw | rat | - | - | NOAEL study | p.21 |
| SCCS Opinion | NOAEL | =300 | mg/kg bw | rat | - | - | NOAEL study | p.21 |
| SCCS Opinion | NOAEL | =500 | mg/kg bw | rat | oral | 16 weeks | NOAEL study | p.21 |
| SCCS Opinion | NOAEL | =500 | mg/kg bw/d | human | - | - | NOAEL study | p.23 |
| SCCS Opinion | NOAEL | =500 | mg/kg bw/day | - | oral | developmental | reproductive toxicity | p.24 |
ToxValDB Alaska DEC 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Alaska DEC | RfD | =4 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15446024:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=00128bf1cd04ccc97b9bcc07ad822af5 |
ECHA 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEL | =340 | mg/kg bw/day | Cat | oral | short-term; 15 days | short-term | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb54e4b0a7c65d225b62; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10053/7/6/2?documentUUID=a97a5c25-b1ff-482d-9c06-e11a40bfd00c; YEAR=1982; ORIGINAL_YEAR=1982; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15835622_15835623_15836064_15836065:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6526e12b8c404c2740e465df9e9899e3 |
| ECHA | LOAEL | =2500 | mg/kg bw/day | Rat | oral | subchronic; 5 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadd4e4b0a7c65d1c61e6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24934/7/6/2?documentUUID=11d691ad-8c1b-4c0d-9f47-9c18d29c10a5; YEAR=1976; ORIGINAL_YEAR=1976; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15838076_15838077:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_05e19aafd4d0c7ea9309146be7b826c3 |
| ECHA | NOAEL | =200 | mg/kg bw/day | Cat | oral | short-term; 15 days | short-term | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb54e4b0a7c65d225b62; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10053/7/6/2?documentUUID=a97a5c25-b1ff-482d-9c06-e11a40bfd00c; YEAR=1982; ORIGINAL_YEAR=1982; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15835622_15835623_15836064_15836065:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_176f41eb459a676bca0176e135fdf5f7 |
| ECHA | NOAEL | =500 | mg/kg bw/day | Rat | oral | subchronic; 5 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadd4e4b0a7c65d1c61e6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24934/7/6/2?documentUUID=11d691ad-8c1b-4c0d-9f47-9c18d29c10a5; YEAR=1976; ORIGINAL_YEAR=1976; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15838076_15838077:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_49325165e836f30a5f3ba72974ad1ed6 |
| ECHA | NOAEL | =648 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadd4e4b0a7c65d1c61d7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24934/7/6/2?documentUUID=11d691ad-8c1b-4c0d-9f47-9c18d29c10a5; YEAR=1976; ORIGINAL_YEAR=1976; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15835795_15842960:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e4bc7e85ce6c850559596828b5dc8565 |
| ECHA | NOAEL | >2500 | mg/kg bw/day | Rabbit | dermal | acute; 6 hours | acute | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61e7ce4b096bca8779dc7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10053/7/6/4?documentUUID=a97a5c25-b1ff-482d-9c06-e11a40bfd00c; YEAR=1982; ORIGINAL_YEAR=1982; STUDY_GROUP=ECHA IUCLID:15826526:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9ee7446d62dae9b68fc57e09c28889fc |
| ECHA | NOEL | =1000 | mg/kg bw/day | Rat | oral | short-term; 2 weeks | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cad6e4b0a7c65d223ab3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24934/7/6/2?documentUUID=11d691ad-8c1b-4c0d-9f47-9c18d29c10a5; YEAR=1976; ORIGINAL_YEAR=1976; STUDY_GROUP=ECHA IUCLID:15834733:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_154513ef75a75d87286d56540a020f29 |
ToxValDB ECOTOX 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =15.2 | g/org-day | Rat | oral | chronic; 224 days | chronic | LONG_REF=Carcinogenesis14(2): 275-280 Shibata,M.A., M. Hirose, M. Kagawa, P. Boonyaphiphat, and N. Ito Enhancing Effect of Concomitant L-Ascorbic Acid Administration on BHA-Induced Forestomach Carcinogenesis in Rats 1993; TITLE=Enhancing Effect of Concomitant L-Ascorbic Acid Administration on BHA-Induced Forestomach Carcinogenesis in Rats; AUTHOR=Shibata,M.A., M. Hirose, M. Kagawa, P. Boonyaphiphat, and N. Ito; DOI=10.1093/carcin/14.2.275; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75903; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX:15599259:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b2231851c484aaaeafef9cd7fd49510d |
| ToxValDB ECOTOX | NOEL | =1000 | mg/kg bw/day | Mouse | oral | acute; 1 days | acute | LONG_REF=Mutat. Res.519(1/2): 103-119 Sasaki,Y.F., S. Kawaguchi, A. Kamaya, M. Ohshita, K. Kabasawa, K. Iwama, K. Taniguchi, and S. Tsuda The Comet Assay with 8 Mouse Organs: Results with 39 Currently Used Food Additives 2002; TITLE=The Comet Assay with 8 Mouse Organs: Results with 39 Currently Used Food Additives; AUTHOR=Sasaki,Y.F., S. Kawaguchi, A. Kamaya, M. Ohshita, K. Kabasawa, K. Iwama, K. Taniguchi, and S. Tsuda; DOI=10.1016/s1383-5718(02)00128-6; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75840; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Genetics: Damage; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15597280:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=52377f612c3fb4f79116f6d28b0039e7 |
ToxValDB GESTIS DNEL 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL local | =0.1 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15630024_15630025:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3747f40811ad6264a478f99892b353a0 |
| ToxValDB GESTIS DNEL | DNEL systemic | =3 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15630024_15630025:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b26027aef50fa7af1e9023a7f30378a8 |
ToxValDB IRIS 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB IRIS | NOAEL | =4.4 | mg/kg bw/day | Human | oral | - | epidemiologic | LONG_REF=FDA (Food and Drug Administration). 1973. Evaluation of the Health Aspects of Benzoic Acid and Sodium Benzoate as Food Ingredients. DHEW, Washington, DC. Report No. SCOGS-7. NTIS PB-223837/6.; TITLE=Evaluation of the Health Aspects of Benzoic Acid and Sodium Benzoate as Food Ingredients; AUTHOR=FDA (Food and Drug Administration); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a3be4b045b9ff7a57a4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=355; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=IRIS:15644411:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_943cf6a96653374cb5cca29933c1340e |
ToxValDB PPRTV (CPHEA) 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB PPRTV (CPHEA) | LOAEL (HEC) | =1.9 | mg/m3 | Rat | inhalation | short-term; 4 weeks | short-term | LONG_REF=IRDC 1981; AUTHOR=IRDC; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b355; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1589; TOXICOLOGICAL_EFFECT=pulmonary effects; STUDY_GROUP=PPRTV (CPHEA):15653423:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_503ff266725b1de1cd43b11aebecc898 |
| ToxValDB PPRTV (CPHEA) | RfC (provisional) | =0.002 | mg/m3 | Human | inhalation | - | Toxicity Value | LONG_REF=IRDC 1981; AUTHOR=IRDC; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b355; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1589; TOXICOLOGICAL_EFFECT=Pulmonary effects in male/female rats; STUDY_GROUP=PPRTV (CPHEA):15653422:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c14b748d583a1d3f623eb9c0d2422e85 |
ToxValDB Uterotrophic Hershberger DB 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Uterotrophic Hershberger DB | LEL | =1 | ug/100 g | Mouse | injection | short-term; 3 days | uterotrophic | LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713785:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_472db6563131ccf67e4fb92e69405abf |
| ToxValDB Uterotrophic Hershberger DB | LEL | =10 | ug/100 g BW | Mouse | injection | short-term; 3 days | uterotrophic | LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713788:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ea863a56fb9e785a6d14e3ab67278a02 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 8SKN0B0MIM | UNII | - | - | - | chemical | - |