NOAEL Studies
Cosmetic Ingredient
Benzophenone NOAEL Studies
INCI: BENZOPHENONE
CAS: 119-61-9 [^1_6]
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
California Proposition 65 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| California Proposition 65 | California Proposition 65 listing | LCcancer | listing type | - | - | 2012-06-22 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"2012-06-22","listing_mechanism":"LC","madl":null,"nsrl":null,"source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | LCcancer | listing type | - | - | 2012-06-22 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"2012-06-22","listing_mechanism":"LC","madl":null,"nsrl":null,"source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | LCcancer | listing type | - | - | 2012-06-22 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"2012-06-22","listing_mechanism":"LC","madl":null,"nsrl":null,"source_table":"prop65_listings"} |
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip 15 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 100 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=007b5ad9-62c8-4191-b587-82a2dbb6f021.i6z; document=8701c83b-8fd7-4854-b260-5da4139c55ce_007b5ad9-62c8-4191-b587-82a2dbb6f021.i6d; document_key=8701c83b-8fd7-4854-b260-5da4139c55ce/007b5ad9-62c8-4191-b587-82a2dbb6f021; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2002; ReportDate=2002-10-23; basis=other:; key_result=false; entry_uuid=49b5663b-b41f-406a-891d-1a0d0843b1fb |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 100 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=007b5ad9-62c8-4191-b587-82a2dbb6f021.i6z; document=8701c83b-8fd7-4854-b260-5da4139c55ce_007b5ad9-62c8-4191-b587-82a2dbb6f021.i6d; document_key=8701c83b-8fd7-4854-b260-5da4139c55ce/007b5ad9-62c8-4191-b587-82a2dbb6f021; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2002; ReportDate=2002-10-23; basis=other:; key_result=false; entry_uuid=49b5663b-b41f-406a-891d-1a0d0843b1fb |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 100 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=007b5ad9-62c8-4191-b587-82a2dbb6f021.i6z; document=8701c83b-8fd7-4854-b260-5da4139c55ce_007b5ad9-62c8-4191-b587-82a2dbb6f021.i6d; document_key=8701c83b-8fd7-4854-b260-5da4139c55ce/007b5ad9-62c8-4191-b587-82a2dbb6f021; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2002; ReportDate=2002-10-23; basis=other:; key_result=false; entry_uuid=49b5663b-b41f-406a-891d-1a0d0843b1fb |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 5 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=007b5ad9-62c8-4191-b587-82a2dbb6f021.i6z; document=cc245c25-4942-4e95-8444-42d6e46fbc71_007b5ad9-62c8-4191-b587-82a2dbb6f021.i6d; document_key=cc245c25-4942-4e95-8444-42d6e46fbc71/007b5ad9-62c8-4191-b587-82a2dbb6f021; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2004; ReportDate=2004-02-26; basis=other:; key_result=false; entry_uuid=4ab5168a-cecc-4120-a13b-cf4722830c95 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 25 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=007b5ad9-62c8-4191-b587-82a2dbb6f021.i6z; document=cc245c25-4942-4e95-8444-42d6e46fbc71_007b5ad9-62c8-4191-b587-82a2dbb6f021.i6d; document_key=cc245c25-4942-4e95-8444-42d6e46fbc71/007b5ad9-62c8-4191-b587-82a2dbb6f021; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2004; ReportDate=2004-02-26; basis=other:; key_result=false; entry_uuid=53ffc1df-a25b-47f6-828f-3d13575198e9 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 20 | mg/kg bw/day | rat | oral: feed | - | short-term repeated dose toxicity: oral | dossier=007b5ad9-62c8-4191-b587-82a2dbb6f021.i6z; document=ad0dd29a-aa40-4f62-9adf-572883eb2ee1_007b5ad9-62c8-4191-b587-82a2dbb6f021.i6d; document_key=ad0dd29a-aa40-4f62-9adf-572883eb2ee1/007b5ad9-62c8-4191-b587-82a2dbb6f021; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1991; basis=other:; key_result=false; entry_uuid=a0e649c1-2eb6-4c32-b944-f62db3bbafbe |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 5 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=007b5ad9-62c8-4191-b587-82a2dbb6f021.i6z; document=cc245c25-4942-4e95-8444-42d6e46fbc71_007b5ad9-62c8-4191-b587-82a2dbb6f021.i6d; document_key=cc245c25-4942-4e95-8444-42d6e46fbc71/007b5ad9-62c8-4191-b587-82a2dbb6f021; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2004; ReportDate=2004-02-26; basis=other:; key_result=false; entry_uuid=4ab5168a-cecc-4120-a13b-cf4722830c95 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 25 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=007b5ad9-62c8-4191-b587-82a2dbb6f021.i6z; document=cc245c25-4942-4e95-8444-42d6e46fbc71_007b5ad9-62c8-4191-b587-82a2dbb6f021.i6d; document_key=cc245c25-4942-4e95-8444-42d6e46fbc71/007b5ad9-62c8-4191-b587-82a2dbb6f021; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2004; ReportDate=2004-02-26; basis=other:; key_result=false; entry_uuid=53ffc1df-a25b-47f6-828f-3d13575198e9 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 20 | mg/kg bw/day | rat | oral: feed | - | short-term repeated dose toxicity: oral | dossier=007b5ad9-62c8-4191-b587-82a2dbb6f021.i6z; document=ad0dd29a-aa40-4f62-9adf-572883eb2ee1_007b5ad9-62c8-4191-b587-82a2dbb6f021.i6d; document_key=ad0dd29a-aa40-4f62-9adf-572883eb2ee1/007b5ad9-62c8-4191-b587-82a2dbb6f021; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1991; basis=other:; key_result=false; entry_uuid=a0e649c1-2eb6-4c32-b944-f62db3bbafbe |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 5 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=007b5ad9-62c8-4191-b587-82a2dbb6f021.i6z; document=cc245c25-4942-4e95-8444-42d6e46fbc71_007b5ad9-62c8-4191-b587-82a2dbb6f021.i6d; document_key=cc245c25-4942-4e95-8444-42d6e46fbc71/007b5ad9-62c8-4191-b587-82a2dbb6f021; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2004; ReportDate=2004-02-26; basis=other:; key_result=false; entry_uuid=4ab5168a-cecc-4120-a13b-cf4722830c95 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 25 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=007b5ad9-62c8-4191-b587-82a2dbb6f021.i6z; document=cc245c25-4942-4e95-8444-42d6e46fbc71_007b5ad9-62c8-4191-b587-82a2dbb6f021.i6d; document_key=cc245c25-4942-4e95-8444-42d6e46fbc71/007b5ad9-62c8-4191-b587-82a2dbb6f021; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2004; ReportDate=2004-02-26; basis=other:; key_result=false; entry_uuid=53ffc1df-a25b-47f6-828f-3d13575198e9 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 20 | mg/kg bw/day | rat | oral: feed | - | short-term repeated dose toxicity: oral | dossier=007b5ad9-62c8-4191-b587-82a2dbb6f021.i6z; document=ad0dd29a-aa40-4f62-9adf-572883eb2ee1_007b5ad9-62c8-4191-b587-82a2dbb6f021.i6d; document_key=ad0dd29a-aa40-4f62-9adf-572883eb2ee1/007b5ad9-62c8-4191-b587-82a2dbb6f021; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1991; basis=other:; key_result=false; entry_uuid=a0e649c1-2eb6-4c32-b944-f62db3bbafbe |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOEL | 20 | mg/kg bw/day | rat | oral: feed | - | sub-chronic toxicity: oral | dossier=f6175585-d14d-4775-ab78-ee1525a2b0d2.i6z; document=8fdd542d-be6e-49e4-910e-1a30af6126fc_f6175585-d14d-4775-ab78-ee1525a2b0d2.i6d; document_key=8fdd542d-be6e-49e4-910e-1a30af6126fc/f6175585-d14d-4775-ab78-ee1525a2b0d2; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1991; basis=histopathology: non-neoplastic; key_result=true; entry_uuid=74d47821-d084-4e2a-ab58-c6c6698b74e8 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOEL | 20 | mg/kg bw/day | rat | oral: feed | - | sub-chronic toxicity: oral | dossier=f6175585-d14d-4775-ab78-ee1525a2b0d2.i6z; document=8fdd542d-be6e-49e4-910e-1a30af6126fc_f6175585-d14d-4775-ab78-ee1525a2b0d2.i6d; document_key=8fdd542d-be6e-49e4-910e-1a30af6126fc/f6175585-d14d-4775-ab78-ee1525a2b0d2; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1991; basis=histopathology: non-neoplastic; key_result=true; entry_uuid=74d47821-d084-4e2a-ab58-c6c6698b74e8 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOEL | 20 | mg/kg bw/day | rat | oral: feed | - | sub-chronic toxicity: oral | dossier=f6175585-d14d-4775-ab78-ee1525a2b0d2.i6z; document=8fdd542d-be6e-49e4-910e-1a30af6126fc_f6175585-d14d-4775-ab78-ee1525a2b0d2.i6d; document_key=8fdd542d-be6e-49e4-910e-1a30af6126fc/f6175585-d14d-4775-ab78-ee1525a2b0d2; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1991; basis=histopathology: non-neoplastic; key_result=true; entry_uuid=74d47821-d084-4e2a-ab58-c6c6698b74e8 |
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | LOAEL | =6 | mg/kg bw/day | Rat | - | - | reproduction toxicity | EFSA CEF - 2009 - OutputID 415 - histopathology non neoplastic - reproductive - EFSA statement on the presence of 4-methylbenzophenone found in breakfast cereals - doi:10.2903/j.efsa.2009.243r |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | LOAEL | =6 | mg/kg bw/day | Rat | - | - | reproduction toxicity | EFSA CEF - 2009 - OutputID 415 - histopathology non neoplastic - reproductive - EFSA statement on the presence of 4-methylbenzophenone found in breakfast cereals - doi:10.2903/j.efsa.2009.243r |
IARC Monographs 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 2B | IARC group | - | - | 2011 | IARC Monographs | {"additional_info":"volume_publication_year=2013","evaluation_year":2011,"source_table":"iarc_classifications","volume":"101"} |
| IARC Monographs | IARC carcinogenicity classification | 2B | IARC group | - | - | 2011 | IARC Monographs | {"additional_info":"volume_publication_year=2013","evaluation_year":2011,"source_table":"iarc_classifications","volume":"101"} |
| IARC Monographs | IARC carcinogenicity classification | 2B | IARC group | - | - | 2011 | IARC Monographs | {"additional_info":"volume_publication_year=2013","evaluation_year":2011,"source_table":"iarc_classifications","volume":"101"} |
NTP_ICE_acute_oral 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | =1900 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1537; row=565; data_type=In Vivo; mixture=Chemical; chemical_name=Benzophenone; preferred_name=Benzophenone; dtxsid=DTXSID0021961; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021961; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0021961; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | >10000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_1539; row=566; data_type=In Vivo; mixture=Chemical; chemical_name=Benzophenone; preferred_name=Benzophenone; dtxsid=DTXSID0021961; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021961; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0021961; source_file=acute_oral.xlsx |
NTP_ICE_adme_parameters 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_adme_parameters | Clint | 9.134 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=131; Record_ID=adme_parameters_265; Data_Type=Measured; DTXSID=DTXSID0021961; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=9.134; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wetmore 2015; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021961 |
| NTP_ICE_adme_parameters | Clint | 56.9 | uL/min/10^6 cells | Rat | - | - | Measured; httk, Rat Hepatic Intrinsic Clearance | sheet=Data; excel_row=133; Record_ID=adme_parameters_265; Data_Type=Measured; DTXSID=DTXSID0021961; Assay=httk, Rat Hepatic Intrinsic Clearance; Endpoint=Clint; Response=56.9; Response_Unit=ul/min/10^6 cells; Species=Rat; Reference=httk2.3.1, Honda 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021961 |
| NTP_ICE_adme_parameters | Fu | 0 | fraction | Rat | - | - | Measured; httk, Rat Plasma Fraction Unbound | sheet=Data; excel_row=132; Record_ID=adme_parameters_265; Data_Type=Measured; DTXSID=DTXSID0021961; Assay=httk, Rat Plasma Fraction Unbound; Endpoint=Fu; Response=0.0; Response_Unit=Unitless Fraction; Species=Rat; Reference=httk2.3.1, Honda 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021961 |
| NTP_ICE_adme_parameters | Fu | 0.06543 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=134; Record_ID=adme_parameters_265; Data_Type=Measured; DTXSID=DTXSID0021961; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.06543; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wetmore 2015; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021961 |
NTP_ICE_cancer 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_cancer | IARC group | 2 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=610; Record_ID=cancer_5988; Data_Type=WOE; Formulation_Name=Benzophenone; Mixture=Chemical; DTXSID=DTXSID0021961; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=2B; Response_Unit=Unitless; URL=http://publications.iarc.fr/125; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021961 |
| NTP_ICE_cancer | POLY-3 lowest dose | 1250 | ppm | Rat | Dosed feed | - | In Vivo; Two year cancer bioassay | sheet=Data; excel_row=603; Record_ID=cancer_5982; Data_Type=In Vivo; Formulation_Name=Benzophenone; Mixture=Chemical; DTXSID=DTXSID0021961; Assay=Two year cancer bioassay; Endpoint=POLY-3 lowest dose; Response=1250; Response_Unit=ppm; Species=Rat; Strain=F344/N; Sex=Male; Route=Dosed feed; Level_of_Evidence=Some evidence; Tissue=Kidney; Location=Renal tubule; Lesion=Adenoma; Reference=TR-533; URL=https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr533/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021961 |
| NTP_ICE_cancer | POLY-3 lowest dose | 625 | ppm | Mouse | Dosed feed | - | In Vivo; Two year cancer bioassay | sheet=Data; excel_row=605; Record_ID=cancer_5983; Data_Type=In Vivo; Formulation_Name=Benzophenone; Mixture=Chemical; DTXSID=DTXSID0021961; Assay=Two year cancer bioassay; Endpoint=POLY-3 lowest dose; Response=625; Response_Unit=ppm; Species=Mouse; Strain=B6C3F1; Sex=Male; Route=Dosed feed; Level_of_Evidence=Some evidence; Tissue=Liver; Lesion=Hepatocellular adenoma; Reference=TR-533; URL=https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr533/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021961 |
| NTP_ICE_cancer | Top dose | 1250 | ppm | Rat | Dosed feed | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=602; Record_ID=cancer_5982; Data_Type=In Vivo; Formulation_Name=Benzophenone; Mixture=Chemical; DTXSID=DTXSID0021961; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=1250; Response_Unit=ppm; Species=Rat; Strain=F344/N; Sex=Male; Route=Dosed feed; Reference=TR-533; URL=https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr533/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021961 |
NTP_ICE_dart 16 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_dart | LOEL | 300 | mg/kg bw/day | Rat | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=5031; Record_ID=dart_22829; Data_Type=In Vivo; DTXSID=DTXSID0021961; Assay=DART, In life observation; Endpoint=LOEL; Response=300; Response_Unit=mg/kg/day; Species=Rat; Strain=CD(SD)BR; Sex=Male/Female; Life_Stage=Fetal; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0005910;CUI;Body Weight|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0751992;CUI;Fetal Weight; Reference=ToxRefDB v2 , ID = 5226; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021961 |
| NTP_ICE_dart | LOEL | 25 | mg/kg bw/day | Rabbit | Oral | - | In Vivo; DART, Reproductive performance | sheet=Data; excel_row=5056; Record_ID=dart_22550; Data_Type=In Vivo; DTXSID=DTXSID0021961; Assay=DART, Reproductive performance; Endpoint=LOEL; Response=25; Response_Unit=mg/kg/day; Species=Rabbit; Strain=New Zealand White; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0035150;CUI;Reproduction|UMLS;C0429914;CUI;Number of miscarriages or induced terminations of pregnancy; Reference=ToxRefDB v2 , ID = 5223; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021961 |
| NTP_ICE_dart | LOEL | 25 | mg/kg bw/day | Rabbit | Oral | - | In Vivo; DART, Reproductive performance | sheet=Data; excel_row=5057; Record_ID=dart_22552; Data_Type=In Vivo; DTXSID=DTXSID0021961; Assay=DART, Reproductive performance; Endpoint=LOEL; Response=25; Response_Unit=mg/kg/day; Species=Rabbit; Strain=New Zealand White; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0035150;CUI;Reproduction|UMLS;C0151526;CUI;Premature Birth; Reference=ToxRefDB v2 , ID = 5223; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021961 |
| NTP_ICE_dart | LOEL | 25 | mg/kg bw/day | Rabbit | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=5058; Record_ID=dart_22554; Data_Type=In Vivo; DTXSID=DTXSID0021961; Assay=DART, In life observation; Endpoint=LOEL; Response=25; Response_Unit=mg/kg/day; Species=Rabbit; Strain=New Zealand White; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0005910;CUI;Body Weight|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0005910;CUI;Body Weight; Reference=ToxRefDB v2 , ID = 5223; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021961 |
| NTP_ICE_dart | LOEL | 25 | mg/kg bw/day | Rabbit | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=5059; Record_ID=dart_22556; Data_Type=In Vivo; DTXSID=DTXSID0021961; Assay=DART, In life observation; Endpoint=LOEL; Response=25; Response_Unit=mg/kg/day; Species=Rabbit; Strain=New Zealand White; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0005910;CUI;Body Weight|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0043094;CUI;Weight Gain; Reference=ToxRefDB v2 , ID = 5223; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021961 |
| NTP_ICE_dart | LOEL | 25 | mg/kg bw/day | Rabbit | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=5060; Record_ID=dart_22558; Data_Type=In Vivo; DTXSID=DTXSID0021961; Assay=DART, In life observation; Endpoint=LOEL; Response=25; Response_Unit=mg/kg/day; Species=Rabbit; Strain=New Zealand White; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C2983605;CUI;Food Consumption|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C2983605;CUI;Food Consumption; Reference=ToxRefDB v2 , ID = 5223; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021961 |
| NTP_ICE_dart | LOEL | 25 | mg/kg bw/day | Rabbit | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=5061; Record_ID=dart_22560; Data_Type=In Vivo; DTXSID=DTXSID0021961; Assay=DART, In life observation; Endpoint=LOEL; Response=25; Response_Unit=mg/kg/day; Species=Rabbit; Strain=New Zealand White; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0026565;CUI;Mortality Vital Statistics|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0026565;CUI;Mortality Vital Statistics; Reference=ToxRefDB v2 , ID = 5223; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021961 |
| NTP_ICE_dart | LOEL | 45 | mg/kg bw/day | Rabbit | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=5062; Record_ID=dart_22646; Data_Type=In Vivo; DTXSID=DTXSID0021961; Assay=DART, In life observation; Endpoint=LOEL; Response=45; Response_Unit=mg/kg/day; Species=Rabbit; Strain=New Zealand White; Sex=Male/Female; Life_Stage=Fetal; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0005910;CUI;Body Weight|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0751992;CUI;Fetal Weight; Reference=ToxRefDB v2 , ID = 5223; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021961 |
| NTP_ICE_dart | LOEL | 100 | mg/kg bw/day | Rat | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=5063; Record_ID=dart_22673; Data_Type=In Vivo; DTXSID=DTXSID0021961; Assay=DART, In life observation; Endpoint=LOEL; Response=100; Response_Unit=mg/kg/day; Species=Rat; Strain=CD(SD)BR; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0005910;CUI;Body Weight|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0005910;CUI;Body Weight; Reference=ToxRefDB v2 , ID = 5226; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021961 |
| NTP_ICE_dart | LOEL | 100 | mg/kg bw/day | Rat | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=5064; Record_ID=dart_22674; Data_Type=In Vivo; DTXSID=DTXSID0021961; Assay=DART, In life observation; Endpoint=LOEL; Response=100; Response_Unit=mg/kg/day; Species=Rat; Strain=CD(SD)BR; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0005910;CUI;Body Weight|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0043094;CUI;Weight Gain; Reference=ToxRefDB v2 , ID = 5226; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021961 |
| NTP_ICE_dart | LOEL | 100 | mg/kg bw/day | Rat | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=5065; Record_ID=dart_22675; Data_Type=In Vivo; DTXSID=DTXSID0021961; Assay=DART, In life observation; Endpoint=LOEL; Response=100; Response_Unit=mg/kg/day; Species=Rat; Strain=CD(SD)BR; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0013911;CUI;Emaciation; Reference=ToxRefDB v2 , ID = 5226; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021961 |
| NTP_ICE_dart | LOEL | 100 | mg/kg bw/day | Rat | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=5066; Record_ID=dart_22676; Data_Type=In Vivo; DTXSID=DTXSID0021961; Assay=DART, In life observation; Endpoint=LOEL; Response=100; Response_Unit=mg/kg/day; Species=Rat; Strain=CD(SD)BR; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0023380;CUI;Lethargy; Reference=ToxRefDB v2 , ID = 5226; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021961 |
| NTP_ICE_dart | LOEL | 100 | mg/kg bw/day | Rat | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=5067; Record_ID=dart_22677; Data_Type=In Vivo; DTXSID=DTXSID0021961; Assay=DART, In life observation; Endpoint=LOEL; Response=100; Response_Unit=mg/kg/day; Species=Rat; Strain=CD(SD)BR; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0031924;CUI;Piloerection; Reference=ToxRefDB v2 , ID = 5226; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021961 |
| NTP_ICE_dart | LOEL | 100 | mg/kg bw/day | Rat | Oral | - | In Vivo; DART, Organ weight | sheet=Data; excel_row=5068; Record_ID=dart_22682; Data_Type=In Vivo; DTXSID=DTXSID0021961; Assay=DART, Organ weight; Endpoint=LOEL; Response=100; Response_Unit=mg/kg/day; Species=Rat; Strain=CD(SD)BR; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0022646;CUI;Kidney|UMLS;C0029218;CUI;Organ Weight|UMLS;C2983636;CUI;Organ to Body Weight Ratio; Reference=ToxRefDB v2 , ID = 5226; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021961 |
| NTP_ICE_dart | LOEL | 100 | mg/kg bw/day | Rat | Oral | - | In Vivo; DART, Organ weight | sheet=Data; excel_row=5069; Record_ID=dart_22683; Data_Type=In Vivo; DTXSID=DTXSID0021961; Assay=DART, Organ weight; Endpoint=LOEL; Response=100; Response_Unit=mg/kg/day; Species=Rat; Strain=CD(SD)BR; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0023884;CUI;Liver|UMLS;C0029218;CUI;Organ Weight|UMLS;C0205344;CUI;Absolute; Reference=ToxRefDB v2 , ID = 5226; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021961 |
| NTP_ICE_dart | LOEL | 100 | mg/kg bw/day | Rat | Oral | - | In Vivo; DART, Organ weight | sheet=Data; excel_row=5070; Record_ID=dart_22684; Data_Type=In Vivo; DTXSID=DTXSID0021961; Assay=DART, Organ weight; Endpoint=LOEL; Response=100; Response_Unit=mg/kg/day; Species=Rat; Strain=CD(SD)BR; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0023884;CUI;Liver|UMLS;C0029218;CUI;Organ Weight|UMLS;C2983636;CUI;Organ to Body Weight Ratio; Reference=ToxRefDB v2 , ID = 5226; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021961 |
NTP_ICE_endocrine 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | AC50 | 48.9096765124865 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=5360; RecordID=ERPathway2016_292; DatasetName=ERPathway2016; DTXSID=DTXSID0021961; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=48.9096765124865; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021961 |
| NTP_ICE_endocrine | ACC | 32.7989859636198 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=5361; RecordID=ERPathway2016_292; DatasetName=ERPathway2016; DTXSID=DTXSID0021961; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=32.7989859636198; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021961 |
| NTP_ICE_endocrine | LOEL | 500 | mg/kg bw/day | Rat | Subcutaneous | Treatment_Duration=3 days; Age_at_First_Dose=PND 19; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3 | In Vivo; Uterotrophic-Agonist | sheet=Data_invivo; excel_row=770; Record_ID=endocrine_invivo_35; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID0021961; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=500; Response_Unit=mg/kg/day; Species=Rat; Sex=Female; Route=Subcutaneous; Maximum_Dose=500; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Takeyoshi 2006; Not available; https://www.oecd.org/env/ehs/testing/37504278.pdf|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021961 |
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=5356; RecordID=ARPathway2016_661; DatasetName=ARPathway2016; DTXSID=DTXSID0021961; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021961 |
| NTP_ICE_endocrine | Model Score | 0.04 | unitless | - | - | - | ERPathway2016; ER Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=5362; RecordID=ERPathway2016_292; DatasetName=ERPathway2016; DTXSID=DTXSID0021961; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.04; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021961 |
| NTP_ICE_endocrine | Uterine weight increase vs control | 120 | % | Rat | Subcutaneous | Treatment_Duration=3 days; Age_at_First_Dose=PND 19; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3 | In Vivo; Uterotrophic-Agonist | sheet=Data_invivo; excel_row=2237; Record_ID=endocrine_invivo_35; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID0021961; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=120; Response_Unit=%; Species=Rat; Sex=Female; Route=Subcutaneous; Maximum_Dose=500; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Takeyoshi 2006; Not available; https://www.oecd.org/env/ehs/testing/37504278.pdf|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021961 |
ToxRefDB_ToxRefDB_v3_pod.csv 19 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =77 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 14 week | SUB | study_id=5217; toxval_study_source_id=studyid5217_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-liver-hypertrophy|organ weight-kidney-relative to body weight|organ weight-liver-absolute|clinical chemistry-albumin-albumin|clinical chemistry-protein-protein|clinical chemistry-cytochrome p450, nos-cytochrome p450, nos|in life observation-body weight-body weight|organ weight-liver-relative to body weight|clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk)|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|organ weight-kidney-absolute|hematology-hemoglobin (hgb)-hemoglobin (hgb)|hematology-hematocrit (hct)-hematocrit (hct)|hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|clinical chemistry-creatinine-creatinine|organ weight-thymus-absolute|pathology microscopic-liver-vacuolization cytoplasmic|clinical chemistry-bile acids-bile acids|hematology-platelet-platelet|clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt)|pathology microscopic-kidney-casts protein|pathology microscopic-kidney-dilatation|clinical chemistry-sorbitol dehydrogenase-sorbitol dehydrogenase|pathology microscopic-kidney-regeneration|in life observation-body weight-body weight gain|clinical chemistry-urea nitrogen-urea nitrogen|in life observation-clinical signs-emaciation|pathology microscopic-bone marrow-atrophy|in life observation-clinical signs-lethargy|pathology microscopic-kidney-necrosis|in life observation-mortality-mortality|in life observation-food consumption-food consumption; dose_level=1; study_year=2000; study_citation=NTP_2000_NTP technical report on the toxicity studies of benzophenone (CAS No. 119-61-9) administered in feed to F344/N rats and B6C3F1 mice_Rats; dsstox_substance_id=DTXSID0021961; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =75 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 14 week | SUB | study_id=5217; toxval_study_source_id=studyid5217_Adult_F0_M_systemic; toxval_effect_list=organ weight-kidney-absolute|organ weight-liver-absolute|clinical chemistry-bile acids-bile acids|pathology microscopic-liver-vacuolization cytoplasmic|organ weight-liver-relative to body weight|organ weight-kidney-relative to body weight|pathology microscopic-kidney-regeneration|pathology microscopic-kidney-casts protein|clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk)|hematology-hematocrit (hct)-hematocrit (hct)|pathology microscopic-kidney-dilatation|in life observation-body weight-body weight|clinical chemistry-cytochrome p450, nos-cytochrome p450, nos|hematology-hemoglobin (hgb)-hemoglobin (hgb)|hematology-reticulocyte-reticulocyte|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|clinical chemistry-creatinine-creatinine|hematology-platelet-platelet|in life observation-clinical signs-emaciation|organ weight-thymus-absolute|pathology microscopic-liver-hypertrophy|organ weight-heart-absolute|in life observation-body weight-body weight gain|clinical chemistry-urea nitrogen-urea nitrogen|in life observation-clinical signs-lethargy|pathology microscopic-kidney-necrosis|pathology gross-seminal vesicle-reduced size|in life observation-food consumption-food consumption|clinical chemistry-sorbitol dehydrogenase-sorbitol dehydrogenase|pathology gross-penis-prolapse|pathology microscopic-bone marrow-atrophy|clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt)|pathology microscopic-testes-atrophy|pathology microscopic-liver-hyperplasia; dose_level=1; study_year=2000; study_citation=NTP_2000_NTP technical report on the toxicity studies of benzophenone (CAS No. 119-61-9) administered in feed to F344/N rats and B6C3F1 mice_Rats; dsstox_substance_id=DTXSID0021961; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =266 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 14 week | SUB | study_id=5219; toxval_study_source_id=studyid5219_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-liver-hypertrophy|clinical chemistry-sorbitol dehydrogenase-sorbitol dehydrogenase|clinical chemistry-cytochrome p450, nos-cytochrome p450, nos|organ weight-kidney-absolute|organ weight-liver-relative to body weight|organ weight-liver-absolute|clinical chemistry-bile acids-bile acids|organ weight-kidney-relative to body weight|pathology microscopic-liver-vacuolization cytoplasmic|in life observation-body weight-body weight gain|organ weight-thymus-absolute|in life observation-body weight-body weight|hematology-hemoglobin (hgb)-hemoglobin (hgb)|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|hematology-hematocrit (hct)-hematocrit (hct)|in life observation-clinical signs-lethargy|in life observation-food consumption-food consumption|in life observation-mortality-mortality|clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk)|in life observation-clinical signs-emaciation|organ weight-thymus-relative to body weight; dose_level=1; study_year=2000; study_citation=NTP_2000_NTP technical report on the toxicity studies of benzophenone (CAS No. 119-61-9) administered in feed to F344/N rats and B6C3F1 mice_Mice; dsstox_substance_id=DTXSID0021961; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =200 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 14 week | SUB | study_id=5219; toxval_study_source_id=studyid5219_Adult_F0_M_systemic; toxval_effect_list=organ weight-liver-absolute|organ weight-liver-relative to body weight|pathology microscopic-liver-hypertrophy|clinical chemistry-cytochrome p450, nos-cytochrome p450, nos|clinical chemistry-sorbitol dehydrogenase-sorbitol dehydrogenase|organ weight-kidney-relative to body weight|clinical chemistry-bile acids-bile acids|organ weight-kidney-absolute|hematology-hematocrit (hct)-hematocrit (hct)|hematology-hemoglobin (hgb)-hemoglobin (hgb)|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|organ weight-epididymis-nos|organ weight-testes-nos|in life observation-body weight-body weight|in life observation-body weight-body weight gain|pathology microscopic-liver-vacuolization cytoplasmic|in life observation-mortality-mortality|in life observation-clinical signs-emaciation|in life observation-clinical signs-lethargy|in life observation-food consumption-food consumption; dose_level=1; study_year=2000; study_citation=NTP_2000_NTP technical report on the toxicity studies of benzophenone (CAS No. 119-61-9) administered in feed to F344/N rats and B6C3F1 mice_Mice; dsstox_substance_id=DTXSID0021961; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =25 | mg/kg bw/day | rabbit (new zealand white; New Zealand White) | oral | 6 GD to 29 GD | DEV | study_id=5223; toxval_study_source_id=studyid5223_Adult Pregnancy_F0_F_reproductive; toxval_effect_list=reproductive performance-premature delivery-premature delivery|reproductive performance-aborted-aborted; dose_level=2; study_year=2004; study_citation=NTP_2004_Developmental toxicity evaluation for benzophenone (CAS No. 119-61-9) administered by gavage to New Zealand White rabbits on gestational days 6 through 29; dsstox_substance_id=DTXSID0021961; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =45 | mg/kg bw/day | rabbit (new zealand white; New Zealand White) | oral | 6 GD to 29 GD | DEV | study_id=5223; toxval_study_source_id=studyid5223_Fetal_Fetal_MF_systemic; toxval_effect_list=in life observation-body weight-fetal weight; dose_level=3; study_year=2004; study_citation=NTP_2004_Developmental toxicity evaluation for benzophenone (CAS No. 119-61-9) administered by gavage to New Zealand White rabbits on gestational days 6 through 29; dsstox_substance_id=DTXSID0021961; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =15 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 105 week | CHR | study_id=5224; toxval_study_source_id=studyid5224_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-liver-hyperplasia|pathology microscopic-liver-hypertrophy|pathology microscopic-kidney-hyperplasia|pathology microscopic-thyroid gland-hyperplasia|in life observation-body weight-body weight|pathology microscopic-spleen-leukemia mononuclear|pathology microscopic-liver-histiocytic sarcoma|pathology microscopic-mammary gland-fibroadenoma|pathology microscopic-kidney-nephropathy|pathology microscopic-lung-histiocytic sarcoma|in life observation-food consumption-food consumption; dose_level=1; study_year=2006; study_citation=NTP_2006_Toxicology and carcinogenesis studies of benzophenone (CAS No. 119-61-9) in F344/N rats and B6C3F1 mice (feed studies)_Rats; dsstox_substance_id=DTXSID0021961; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =35 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 105 week | CHR | study_id=5225; toxval_study_source_id=studyid5225_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-kidney-nephropathy|in life observation-body weight-body weight|pathology microscopic-spleen-hyperplasia|pathology microscopic-liver-hypertrophy|pathology microscopic-kidney-mineralization|pathology microscopic-spleen-hematopoietic cell proliferation|pathology microscopic-liver-hepatocellular adenoma|pathology gross-full gross necropsy-histiocytic sarcoma|in life observation-mortality-mortality|pathology microscopic-nose-metaplasia|pathology microscopic-liver-inflammation; dose_level=1; study_year=2006; study_citation=NTP_2006_Toxicology and carcinogenesis studies of benzophenone (CAS No. 119-61-9) in F344/N rats and B6C3F1 mice (feed studies)_Mice; dsstox_substance_id=DTXSID0021961; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =40 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 105 week | CHR | study_id=5225; toxval_study_source_id=studyid5225_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-liver-hepatocellular adenoma|pathology microscopic-liver-multinucleated|pathology microscopic-spleen-hyperplasia|pathology microscopic-liver-inflammation|pathology microscopic-liver-hypertrophy|pathology microscopic-kidney-nephropathy|pathology microscopic-kidney-cyst|pathology microscopic-liver-necrosis|pathology microscopic-liver-degeneration|pathology microscopic-liver-clear cell focus|pathology microscopic-testes-mineralization|pathology microscopic-nose-metaplasia; dose_level=1; study_year=2006; study_citation=NTP_2006_Toxicology and carcinogenesis studies of benzophenone (CAS No. 119-61-9) in F344/N rats and B6C3F1 mice (feed studies)_Mice; dsstox_substance_id=DTXSID0021961; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =100 | mg/kg bw/day | rat (sprague dawley; CD(SD)BR) | oral | 6 GD to 19 GD | DEV | study_id=5226; toxval_study_source_id=studyid5226_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain|organ weight-liver-relative to body weight|in life observation-food consumption-food consumption|in life observation-clinical signs-post-dosing rooting in bedding|in life observation-clinical signs-emaciation|in life observation-clinical signs-piloerection|in life observation-clinical signs-lethargy|organ weight-liver-absolute|organ weight-kidney-relative to body weight|in life observation-water consumption-water consumption|in life observation-body weight-body weight|organ weight-kidney-absolute; dose_level=1; study_year=2002; study_citation=NTP_2002_Developmental toxicity evaluation for benzophenone (CAS No. 119-61-9) administered by gavage to Sprague-Dawley (CD) rats on gestational days 6 through 19; dsstox_substance_id=DTXSID0021961; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =539 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 14 week | SUB | study_id=5219; toxval_study_source_id=studyid5219_Adult_F0_F_systemic; toxval_effect_list=organ weight-kidney-absolute|organ weight-kidney-relative to body weight|pathology microscopic-liver-hypertrophy|clinical chemistry-sorbitol dehydrogenase-sorbitol dehydrogenase|organ weight-liver-absolute|clinical chemistry-bile acids-bile acids|organ weight-liver-relative to body weight; dose_level=2; study_year=2000; study_citation=NTP_2000_NTP technical report on the toxicity studies of benzophenone (CAS No. 119-61-9) administered in feed to F344/N rats and B6C3F1 mice_Mice; dsstox_substance_id=DTXSID0021961; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =404 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 14 week | SUB | study_id=5219; toxval_study_source_id=studyid5219_Adult_F0_M_systemic; toxval_effect_list=clinical chemistry-sorbitol dehydrogenase-sorbitol dehydrogenase|organ weight-kidney-relative to body weight|clinical chemistry-bile acids-bile acids|organ weight-kidney-absolute|pathology microscopic-liver-hypertrophy|organ weight-liver-relative to body weight|organ weight-liver-absolute; dose_level=2; study_year=2000; study_citation=NTP_2000_NTP technical report on the toxicity studies of benzophenone (CAS No. 119-61-9) administered in feed to F344/N rats and B6C3F1 mice_Mice; dsstox_substance_id=DTXSID0021961; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =30 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 105 week | CHR | study_id=5224; toxval_study_source_id=studyid5224_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-liver-hypertrophy|pathology microscopic-kidney-hyperplasia|in life observation-body weight-body weight|pathology microscopic-liver-hyperplasia|pathology microscopic-kidney-nephropathy|pathology microscopic-thyroid gland-hyperplasia; dose_level=2; study_year=2006; study_citation=NTP_2006_Toxicology and carcinogenesis studies of benzophenone (CAS No. 119-61-9) in F344/N rats and B6C3F1 mice (feed studies)_Rats; dsstox_substance_id=DTXSID0021961; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =70 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 105 week | CHR | study_id=5225; toxval_study_source_id=studyid5225_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-kidney-mineralization|pathology microscopic-spleen-hematopoietic cell proliferation|pathology microscopic-liver-hypertrophy|pathology microscopic-spleen-hyperplasia|in life observation-body weight-body weight|pathology microscopic-kidney-nephropathy; dose_level=2; study_year=2006; study_citation=NTP_2006_Toxicology and carcinogenesis studies of benzophenone (CAS No. 119-61-9) in F344/N rats and B6C3F1 mice (feed studies)_Mice; dsstox_substance_id=DTXSID0021961; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =80 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 105 week | CHR | study_id=5225; toxval_study_source_id=studyid5225_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-kidney-cyst|pathology microscopic-liver-necrosis|pathology microscopic-liver-multinucleated|pathology microscopic-spleen-hyperplasia|pathology microscopic-liver-hypertrophy|pathology microscopic-liver-inflammation|pathology microscopic-kidney-nephropathy|pathology microscopic-liver-degeneration; dose_level=2; study_year=2006; study_citation=NTP_2006_Toxicology and carcinogenesis studies of benzophenone (CAS No. 119-61-9) in F344/N rats and B6C3F1 mice (feed studies)_Mice; dsstox_substance_id=DTXSID0021961; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =300 | mg/kg bw/day | rat (sprague dawley; CD(SD)BR) | oral | 6 GD to 19 GD | DEV | study_id=5226; toxval_study_source_id=studyid5226_Fetal_Fetal_MF_systemic; toxval_effect_list=in life observation-body weight-fetal weight; dose_level=3; study_year=2002; study_citation=NTP_2002_Developmental toxicity evaluation for benzophenone (CAS No. 119-61-9) administered by gavage to Sprague-Dawley (CD) rats on gestational days 6 through 19; dsstox_substance_id=DTXSID0021961; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | >0 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 14 week | SUB | study_id=5217; toxval_study_source_id=studyid5217_Adult_F0_F_systemic; toxval_effect_list=organ weight-thymus-absolute|organ weight-liver-relative to body weight|in life observation-clinical signs-emaciation|in life observation-body weight-body weight|clinical chemistry-creatinine-creatinine|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|pathology microscopic-kidney-regeneration|in life observation-body weight-body weight gain|pathology microscopic-bone marrow-atrophy|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|clinical chemistry-urea nitrogen-urea nitrogen|clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk)|organ weight-kidney-relative to body weight|clinical chemistry-bile acids-bile acids|pathology microscopic-liver-hypertrophy|pathology microscopic-liver-vacuolization cytoplasmic|hematology-platelet-platelet|in life observation-mortality-mortality|clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt)|hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|in life observation-food consumption-food consumption|pathology microscopic-kidney-casts protein|pathology microscopic-kidney-dilatation|organ weight-liver-absolute|organ weight-kidney-absolute|clinical chemistry-albumin-albumin|in life observation-clinical signs-lethargy|clinical chemistry-protein-protein|hematology-hematocrit (hct)-hematocrit (hct)|clinical chemistry-sorbitol dehydrogenase-sorbitol dehydrogenase|hematology-hemoglobin (hgb)-hemoglobin (hgb)|pathology microscopic-kidney-necrosis|clinical chemistry-cytochrome p450, nos-cytochrome p450, nos; dose_level=0; study_year=2000; study_citation=NTP_2000_NTP technical report on the toxicity studies of benzophenone (CAS No. 119-61-9) administered in feed to F344/N rats and B6C3F1 mice_Rats; dsstox_substance_id=DTXSID0021961; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =5 | mg/kg bw/day | rabbit (new zealand white; New Zealand White) | oral | 6 GD to 29 GD | DEV | study_id=5223; toxval_study_source_id=studyid5223_Adult Pregnancy_F0_F_reproductive; toxval_effect_list=reproductive performance-premature delivery-premature delivery|reproductive performance-aborted-aborted; dose_level=1; study_year=2004; study_citation=NTP_2004_Developmental toxicity evaluation for benzophenone (CAS No. 119-61-9) administered by gavage to New Zealand White rabbits on gestational days 6 through 29; dsstox_substance_id=DTXSID0021961; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NOAEL | =200 | mg/kg bw/day | rat (sprague dawley; CD(SD)BR) | oral | 6 GD to 19 GD | DEV | study_id=5226; toxval_study_source_id=studyid5226_Fetal_Fetal_MF_systemic; toxval_effect_list=in life observation-body weight-fetal weight; dose_level=2; study_year=2002; study_citation=NTP_2002_Developmental toxicity evaluation for benzophenone (CAS No. 119-61-9) administered by gavage to Sprague-Dawley (CD) rats on gestational days 6 through 19; dsstox_substance_id=DTXSID0021961; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB_ECHA_IUCLID 12 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LOAEL | =57.72 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9d8e4b0a7c65d1b3041; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7366/7/8?documentUUID=007b5ad9-62c8-4191-b587-82a2dbb6f021; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816394_15816395_15820528:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a321495b61ec73f7731219b5e468c425 |
| ToxValDB_ECHA_IUCLID | LOAEL | =100 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabc5e4b0a7c65d1bbb2a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7366/7/9/3?documentUUID=f6175585-d14d-4775-ab78-ee1525a2b0d2; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID:15824094:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_73250325ea525c849af3b04bc41f59ce |
| ToxValDB_ECHA_IUCLID | LOAEL | =231.25 | mg/kg bw/day | Mouse | oral | chronic; 14 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacf9e4b0a7c65d1c1d00; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7366/7/6/2?documentUUID=007b5ad9-62c8-4191-b587-82a2dbb6f021; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID:15850479:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_72115005fc543979a33ec2da72c64333 |
| ToxValDB_ECHA_IUCLID | LOAEL | =97.5 | mg/kg bw/day | Rat | oral | chronic; 14 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacf9e4b0a7c65d1c1d10; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7366/7/6/2?documentUUID=007b5ad9-62c8-4191-b587-82a2dbb6f021; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15850480_15850481:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_25bed9479b912c64217f19f3e66a8c48 |
| ToxValDB_ECHA_IUCLID | NOAEC | <=24.336 | mg/kg bw/day | Rat | oral | - | chronic | GUIDELINE=EPA OPPTS 870.4200 (Carcinogenicity); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9d8e4b0a7c65d1b3047; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7366/7/8?documentUUID=f6175585-d14d-4775-ab78-ee1525a2b0d2; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=histopathology: neoplastic|histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=cancer|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15817832_15820301:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d002a29ab0f7feafa78aa2abf10b9fb0 |
| ToxValDB_ECHA_IUCLID | NOAEL | =59.2 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9d8e4b0a7c65d1b3041; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7366/7/8?documentUUID=007b5ad9-62c8-4191-b587-82a2dbb6f021; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816394_15816395_15820528:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f81a175496bdf35670af26bdbe7b9f0e |
| ToxValDB_ECHA_IUCLID | NOAEL | =24.96 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9d8e4b0a7c65d1b3045; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7366/7/8?documentUUID=007b5ad9-62c8-4191-b587-82a2dbb6f021; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID:15820302:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f8cde8cebaf93a6e27a9e933bd6dc803 |
| ToxValDB_ECHA_IUCLID | NOAEL | =25 | mg/kg bw/day | Rabbit | oral | - | developmental | GUIDELINE=EPA OPPTS 870.3700 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabc5e4b0a7c65d1bbb2f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7366/7/9/3?documentUUID=f6175585-d14d-4775-ab78-ee1525a2b0d2; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID:15823345:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9704dcb321a347c4adfc8c3215945553 |
| ToxValDB_ECHA_IUCLID | NOAEL | <100 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabc5e4b0a7c65d1bbb2a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7366/7/9/3?documentUUID=f6175585-d14d-4775-ab78-ee1525a2b0d2; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID:15825447:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e3fec66474882021ecb8b6812a7825ac |
| ToxValDB_ECHA_IUCLID | NOAEL | >20 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacf9e4b0a7c65d1c1d0e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7366/7/6/2?documentUUID=007b5ad9-62c8-4191-b587-82a2dbb6f021; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15847524_15848082_15848533:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_aa7bc1accf468d10be529b4b3cedfc6c |
| ToxValDB_ECHA_IUCLID | NOEL | >2000 | ppm | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c89fe4b0a7c65d2195cf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7366/7/9/2?documentUUID=f6175585-d14d-4775-ab78-ee1525a2b0d2; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15857991_15858066:M/F:P1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1c5ed8746a0add3c96228ec57b6e24d6 |
| ToxValDB_ECHA_IUCLID | NOEL | =450 | ppm | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c89fe4b0a7c65d2195cf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7366/7/9/2?documentUUID=f6175585-d14d-4775-ab78-ee1525a2b0d2; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=F1: body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID:15858934:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c6e50b929777bc54807fd1a550631b70 |
ToxValDB_EFSA 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_EFSA | BMDL (10) | =3.1 | mg/kg bw/day | Rat | oral | chronic; 105 weeks | chronic | LONG_REF=EFSA CEF (2009). Toxicological evaluation of benzophenone - Scientific Opinion of the Panel on food contact materials, enzymes, flavourings and processing aids (CEF). doi:10.2903/j.efsa.2009.1104.; TITLE=Toxicological evaluation of benzophenone - Scientific Opinion of the Panel on food contact materials, enzymes, flavourings and processing aids (CEF); AUTHOR=EFSA CEF; DOI=doi:10.2903/j.efsa.2009.1104; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=histopathology: nonneoplastic; STUDY_GROUP=EFSA:15614303:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_93a43434fbf811ff0e60f2d4b5f2bc9c |
| ToxValDB_EFSA | LOAEL | =6 | mg/kg bw/day | Rat | oral | - | reproduction developmental | LONG_REF=EFSA CEF (2009). EFSA statement on the presence of 4-methylbenzophenone found in breakfast cereals. doi:10.2903/j.efsa.2009.243r.; TITLE=EFSA statement on the presence of 4-methylbenzophenone found in breakfast cereals; AUTHOR=EFSA CEF; DOI=doi:10.2903/j.efsa.2009.243r; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=histopathology: nonneoplastic; STUDY_GROUP=EFSA:15614302:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_383ddbee038f6e206b2bc229b02aacca |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =0.7 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630034:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_430762e2eedfa95b537b5d617cd7597c |
ToxValDB_MN_MDH_HHBW 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_MN_MDH_HHBW | NOAEL | =6.4 | mg/kg bw/day | Rat | oral | subchronic (developmental) | reproduction developmental | LONG_REF=Hoshino, N., Tani, E., Wako, Y., & Takahashi, K. (2005). A two-generation reproductive toxicity study of benzophenone in rats. J Toxicol Sci, 30 Spec No., 5-20; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c98af0e4b02565fc7d4e5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.health.state.mn.us/communities/environment/risk/guidance/gw/table.html; SUBSOURCE_URL=https://www.health.state.mn.us/communities/environment/risk/docs/guidance/gw/benzophenone.pdf; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Increased relative liver weight, relative kidney weight, proximal tubule regeneration, proximal tubule dilatation; STUDY_GROUP=MN MDH HHBW:15952745:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_379b0dae5627817d35abf7a96e4854b0 |
ToxValDB_ToxRefDB 17 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ToxRefDB | LEL | =77 | mg/kg bw/day | Rat | oral | chronic; 14 weeks | chronic | LONG_REF=NTP_2000_NTP technical report on the toxicity studies of benzophenone (CAS No. 119-61-9) administered in feed to F344/N rats and B6C3F1 mice_Rats; TITLE=NTP technical report on the toxicity studies of benzophenone (CAS No. 119-61-9) administered in feed to F344/N rats and B6C3F1 mice_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5217; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-absolute|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-liver-hypertrophy|systemic: organ weight-kidney-relative to body weight|systemic: organ weight-liver-relative to body weight|systemic: clinical chemistry-albumin-albumin|systemic: clinical chemistry-protein-protein|systemic: clinical chemistry-cytochrome p450, nos-cytochrome p450, nos|systemic: clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk)|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: organ weight-kidney-absolute|systemic: hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: clinical chemistry-creatinine-creatinine|systemic: organ weight-thymus-absolute|systemic: pathology microscopic-liver-vacuolization cytoplasmic|systemic: pathology microscopic-kidney-dilatation|systemic: clinical chemistry-bile acids-bile acids|systemic: hematology-platelet-platelet|systemic: clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt)|systemic: pathology microscopic-kidney-regeneration|systemic: in life observation-body weight-body weight gain|systemic: pathology microscopic-kidney-casts protein|systemic: clinical chemistry-sorbitol dehydrogenase-sorbitol dehydrogenase|systemic: in life observation-clinical signs-emaciation|systemic: in life observation-clinical signs-lethargy|systemic: pathology microscopic-bone marrow-atrophy|systemic: clinical chemistry-urea nitrogen-urea nitrogen|systemic: in life observation-mortality-mortality|systemic: in life observation-food consumption-food consumption|systemic: pathology microscopic-kidney-necrosis; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|hematology|mortality/survival|multiple|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708772_15708773:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_87574aa3c52be01322f07d4fc3bfbd2e |
| ToxValDB_ToxRefDB | LEL | =75 | mg/kg bw/day | Rat | oral | chronic; 14 weeks | chronic | LONG_REF=NTP_2000_NTP technical report on the toxicity studies of benzophenone (CAS No. 119-61-9) administered in feed to F344/N rats and B6C3F1 mice_Rats; TITLE=NTP technical report on the toxicity studies of benzophenone (CAS No. 119-61-9) administered in feed to F344/N rats and B6C3F1 mice_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5217; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=systemic: organ weight-kidney-absolute|systemic: organ weight-liver-relative to body weight|systemic: organ weight-kidney-relative to body weight|systemic: organ weight-liver-absolute|systemic: pathology microscopic-kidney-regeneration|systemic: pathology microscopic-kidney-casts protein|systemic: pathology microscopic-liver-vacuolization cytoplasmic|systemic: clinical chemistry-bile acids-bile acids|systemic: clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk)|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: in life observation-body weight-body weight|systemic: clinical chemistry-cytochrome p450, nos-cytochrome p450, nos|systemic: pathology microscopic-kidney-dilatation|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: hematology-reticulocyte-reticulocyte|systemic: hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|systemic: clinical chemistry-creatinine-creatinine|systemic: hematology-platelet-platelet|systemic: in life observation-clinical signs-emaciation|systemic: organ weight-thymus-absolute|systemic: pathology microscopic-liver-hypertrophy|systemic: organ weight-heart-absolute|systemic: in life observation-body weight-body weight gain|systemic: clinical chemistry-urea nitrogen-urea nitrogen|systemic: pathology microscopic-kidney-necrosis|systemic: pathology gross-seminal vesicle-reduced size|systemic: in life observation-clinical signs-lethargy|systemic: in life observation-food consumption-food consumption|systemic: clinical chemistry-sorbitol dehydrogenase-sorbitol dehydrogenase|systemic: pathology gross-penis-prolapse|systemic: clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt)|systemic: pathology microscopic-liver-hyperplasia|systemic: pathology microscopic-testes-atrophy|systemic: pathology microscopic-bone marrow-atrophy; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|gross pathology|hematology|multiple|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708774_15708775:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f4e87209c81d745f6ae5c1ebb0e16622 |
| ToxValDB_ToxRefDB | LEL | =266 | mg/kg bw/day | Mouse | oral | chronic; 14 weeks | chronic | LONG_REF=NTP_2000_NTP technical report on the toxicity studies of benzophenone (CAS No. 119-61-9) administered in feed to F344/N rats and B6C3F1 mice_Mice; TITLE=NTP technical report on the toxicity studies of benzophenone (CAS No. 119-61-9) administered in feed to F344/N rats and B6C3F1 mice_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5219; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-absolute|systemic: organ weight-liver-relative to body weight|systemic: pathology microscopic-liver-hypertrophy|systemic: clinical chemistry-cytochrome p450, nos-cytochrome p450, nos|systemic: clinical chemistry-bile acids-bile acids|systemic: clinical chemistry-sorbitol dehydrogenase-sorbitol dehydrogenase|systemic: organ weight-kidney-absolute|systemic: organ weight-kidney-relative to body weight|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: pathology microscopic-liver-vacuolization cytoplasmic|systemic: in life observation-body weight-body weight gain|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: organ weight-thymus-absolute|systemic: in life observation-body weight-body weight|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: in life observation-clinical signs-emaciation|systemic: in life observation-food consumption-food consumption|systemic: in life observation-clinical signs-lethargy|systemic: organ weight-thymus-relative to body weight|systemic: in life observation-mortality-mortality|systemic: clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk); TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|hematology|mortality/survival|multiple|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708776_15708777_15708778:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5efb45625b63952f8e9994a3ec4fe59e |
| ToxValDB_ToxRefDB | LEL | =200 | mg/kg bw/day | Mouse | oral | chronic; 14 weeks | chronic | LONG_REF=NTP_2000_NTP technical report on the toxicity studies of benzophenone (CAS No. 119-61-9) administered in feed to F344/N rats and B6C3F1 mice_Mice; TITLE=NTP technical report on the toxicity studies of benzophenone (CAS No. 119-61-9) administered in feed to F344/N rats and B6C3F1 mice_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5219; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-absolute|systemic: organ weight-liver-relative to body weight|systemic: clinical chemistry-cytochrome p450, nos-cytochrome p450, nos|systemic: pathology microscopic-liver-hypertrophy|systemic: clinical chemistry-sorbitol dehydrogenase-sorbitol dehydrogenase|systemic: organ weight-kidney-relative to body weight|systemic: organ weight-kidney-absolute|systemic: clinical chemistry-bile acids-bile acids|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: in life observation-body weight-body weight|systemic: organ weight-testes-nos|systemic: in life observation-body weight-body weight gain|systemic: organ weight-epididymis-nos|systemic: in life observation-food consumption-food consumption|systemic: pathology microscopic-liver-vacuolization cytoplasmic|systemic: in life observation-mortality-mortality|systemic: in life observation-clinical signs-emaciation|systemic: in life observation-clinical signs-lethargy; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|hematology|mortality/survival|multiple|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708779_15708780_15708781:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_05f543fb58531c94a78ea78f32675882 |
| ToxValDB_ToxRefDB | LEL | =25 | mg/kg bw/day | Rabbit | oral | short-term (developmental); 24 days | reproduction developmental | LONG_REF=NTP_2004_Developmental toxicity evaluation for benzophenone (CAS No. 119-61-9) administered by gavage to New Zealand White rabbits on gestational days 6 through 29; TITLE=Developmental toxicity evaluation for benzophenone (CAS No. 119-61-9) administered by gavage to New Zealand White rabbits on gestational days 6 through 29; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5223; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=reproductive: reproductive performance-premature delivery-premature delivery|reproductive: reproductive performance-aborted-aborted; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ToxRefDB_dup_-_15708782_15708783_15708784_15708785:F:F0adult-pregnancy; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f296789b9ed921b864ef29a3dd379628 |
| ToxValDB_ToxRefDB | LEL | =45 | mg/kg bw/day | Rabbit | oral | short-term (developmental); 24 days | developmental | LONG_REF=NTP_2004_Developmental toxicity evaluation for benzophenone (CAS No. 119-61-9) administered by gavage to New Zealand White rabbits on gestational days 6 through 29; TITLE=Developmental toxicity evaluation for benzophenone (CAS No. 119-61-9) administered by gavage to New Zealand White rabbits on gestational days 6 through 29; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5223; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-fetal weight; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ToxRefDB_dup_-_15708790_15708791_15708792_15708793:M/F:fetusfetal; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d420213af70fc718209c9cb5b24fd8df |
| ToxValDB_ToxRefDB | LEL | =15 | mg/kg bw/day | Rat | oral | chronic; 105 weeks | chronic | LONG_REF=NTP_2006_Toxicology and carcinogenesis studies of benzophenone (CAS No. 119-61-9) in F344/N rats and B6C3F1 mice (feed studies)_Rats; TITLE=Toxicology and carcinogenesis studies of benzophenone (CAS No. 119-61-9) in F344/N rats and B6C3F1 mice (feed studies)_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5224; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-liver-hypertrophy|systemic: pathology microscopic-liver-hyperplasia|systemic: pathology microscopic-kidney-hyperplasia|systemic: pathology microscopic-thyroid gland-hyperplasia|systemic: pathology microscopic-spleen-leukemia mononuclear|systemic: pathology microscopic-liver-histiocytic sarcoma|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-lung-histiocytic sarcoma|systemic: pathology microscopic-mammary gland-fibroadenoma|systemic: pathology microscopic-kidney-nephropathy|systemic: in life observation-food consumption-food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|food and/or water consumption|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15708794_15708795_15708796:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3300419a82fac9c936e6184f7e426c2f |
| ToxValDB_ToxRefDB | LEL | =35 | mg/kg bw/day | Mouse | oral | chronic; 105 weeks | chronic | LONG_REF=NTP_2006_Toxicology and carcinogenesis studies of benzophenone (CAS No. 119-61-9) in F344/N rats and B6C3F1 mice (feed studies)_Mice; TITLE=Toxicology and carcinogenesis studies of benzophenone (CAS No. 119-61-9) in F344/N rats and B6C3F1 mice (feed studies)_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5225; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-kidney-mineralization|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-spleen-hyperplasia|systemic: pathology microscopic-liver-hypertrophy|systemic: pathology microscopic-kidney-nephropathy|systemic: pathology microscopic-spleen-hematopoietic cell proliferation|systemic: pathology microscopic-liver-hepatocellular adenoma|systemic: pathology gross-full gross necropsy-histiocytic sarcoma|systemic: pathology microscopic-nose-metaplasia|systemic: pathology microscopic-liver-inflammation|systemic: in life observation-mortality-mortality; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|mortality/survival|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15708800_15708801_15708802:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a723ef05087df2eadfe322f6342cc1c1 |
| ToxValDB_ToxRefDB | LEL | =40 | mg/kg bw/day | Mouse | oral | chronic; 105 weeks | chronic | LONG_REF=NTP_2006_Toxicology and carcinogenesis studies of benzophenone (CAS No. 119-61-9) in F344/N rats and B6C3F1 mice (feed studies)_Mice; TITLE=Toxicology and carcinogenesis studies of benzophenone (CAS No. 119-61-9) in F344/N rats and B6C3F1 mice (feed studies)_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5225; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-kidney-nephropathy|systemic: pathology microscopic-liver-hepatocellular adenoma|systemic: pathology microscopic-spleen-hyperplasia|systemic: pathology microscopic-liver-inflammation|systemic: pathology microscopic-liver-hypertrophy|systemic: pathology microscopic-liver-multinucleated|systemic: pathology microscopic-liver-necrosis|systemic: pathology microscopic-liver-degeneration|systemic: pathology microscopic-kidney-cyst|systemic: pathology microscopic-liver-clear cell focus|systemic: pathology microscopic-testes-mineralization|systemic: pathology microscopic-nose-metaplasia; TOXICOLOGICAL_EFFECT_CATEGORY=cancer|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15708803_15708804_15708805:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4b127c8053bc57d4357647ea9e58ec8a |
| ToxValDB_ToxRefDB | LOAEL | =539 | mg/kg bw/day | Mouse | oral | chronic; 14 weeks | chronic | LONG_REF=NTP_2000_NTP technical report on the toxicity studies of benzophenone (CAS No. 119-61-9) administered in feed to F344/N rats and B6C3F1 mice_Mice; TITLE=NTP technical report on the toxicity studies of benzophenone (CAS No. 119-61-9) administered in feed to F344/N rats and B6C3F1 mice_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5219; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-absolute|systemic: organ weight-kidney-relative to body weight|systemic: organ weight-liver-relative to body weight|systemic: pathology microscopic-liver-hypertrophy|systemic: clinical chemistry-bile acids-bile acids|systemic: clinical chemistry-sorbitol dehydrogenase-sorbitol dehydrogenase|systemic: organ weight-kidney-absolute; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708776_15708777_15708778:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e39e5d79429e0fc041907d3413d44db3 |
| ToxValDB_ToxRefDB | LOAEL | =404 | mg/kg bw/day | Mouse | oral | chronic; 14 weeks | chronic | LONG_REF=NTP_2000_NTP technical report on the toxicity studies of benzophenone (CAS No. 119-61-9) administered in feed to F344/N rats and B6C3F1 mice_Mice; TITLE=NTP technical report on the toxicity studies of benzophenone (CAS No. 119-61-9) administered in feed to F344/N rats and B6C3F1 mice_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5219; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=systemic: clinical chemistry-sorbitol dehydrogenase-sorbitol dehydrogenase|systemic: organ weight-kidney-relative to body weight|systemic: organ weight-kidney-absolute|systemic: pathology microscopic-liver-hypertrophy|systemic: organ weight-liver-relative to body weight|systemic: clinical chemistry-bile acids-bile acids|systemic: organ weight-liver-absolute; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708779_15708780_15708781:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1fb032b887422fe7e9bef12105df7440 |
| ToxValDB_ToxRefDB | LOAEL | =30 | mg/kg bw/day | Rat | oral | chronic; 105 weeks | chronic | LONG_REF=NTP_2006_Toxicology and carcinogenesis studies of benzophenone (CAS No. 119-61-9) in F344/N rats and B6C3F1 mice (feed studies)_Rats; TITLE=Toxicology and carcinogenesis studies of benzophenone (CAS No. 119-61-9) in F344/N rats and B6C3F1 mice (feed studies)_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5224; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-liver-hypertrophy|systemic: pathology microscopic-liver-hyperplasia|systemic: pathology microscopic-kidney-hyperplasia|systemic: pathology microscopic-thyroid gland-hyperplasia|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-kidney-nephropathy; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15708794_15708795_15708796:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_00c82a21d67098f368b0b2aabc98d237 |
| ToxValDB_ToxRefDB | LOAEL | =70 | mg/kg bw/day | Mouse | oral | chronic; 105 weeks | chronic | LONG_REF=NTP_2006_Toxicology and carcinogenesis studies of benzophenone (CAS No. 119-61-9) in F344/N rats and B6C3F1 mice (feed studies)_Mice; TITLE=Toxicology and carcinogenesis studies of benzophenone (CAS No. 119-61-9) in F344/N rats and B6C3F1 mice (feed studies)_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5225; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-spleen-hyperplasia|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-kidney-mineralization|systemic: pathology microscopic-spleen-hematopoietic cell proliferation|systemic: pathology microscopic-liver-hypertrophy|systemic: pathology microscopic-kidney-nephropathy; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15708800_15708801_15708802:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_72ead176f862ddf2f1a9c71defa1371a |
| ToxValDB_ToxRefDB | LOAEL | =80 | mg/kg bw/day | Mouse | oral | chronic; 105 weeks | chronic | LONG_REF=NTP_2006_Toxicology and carcinogenesis studies of benzophenone (CAS No. 119-61-9) in F344/N rats and B6C3F1 mice (feed studies)_Mice; TITLE=Toxicology and carcinogenesis studies of benzophenone (CAS No. 119-61-9) in F344/N rats and B6C3F1 mice (feed studies)_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5225; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-spleen-hyperplasia|systemic: pathology microscopic-kidney-nephropathy|systemic: pathology microscopic-liver-necrosis|systemic: pathology microscopic-liver-hypertrophy|systemic: pathology microscopic-liver-multinucleated|systemic: pathology microscopic-liver-degeneration|systemic: pathology microscopic-liver-inflammation|systemic: pathology microscopic-kidney-cyst; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15708803_15708804_15708805:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f361925e73b055cd221fd5318e020211 |
| ToxValDB_ToxRefDB | LOAEL | =300 | mg/kg bw/day | Rat | oral | short-term (developmental); 14 days | developmental | LONG_REF=NTP_2002_Developmental toxicity evaluation for benzophenone (CAS No. 119-61-9) administered by gavage to Sprague-Dawley (CD) rats on gestational days 6 through 19; TITLE=Developmental toxicity evaluation for benzophenone (CAS No. 119-61-9) administered by gavage to Sprague-Dawley (CD) rats on gestational days 6 through 19; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5226; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-fetal weight; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ToxRefDB_dup_-_15708808_15708809_15708810:M/F:fetusfetal; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_75fe8e2a5f797b72625c0a6431542038 |
| ToxValDB_ToxRefDB | NEL | =5 | mg/kg bw/day | Rabbit | oral | short-term (developmental); 24 days | reproduction developmental | LONG_REF=NTP_2004_Developmental toxicity evaluation for benzophenone (CAS No. 119-61-9) administered by gavage to New Zealand White rabbits on gestational days 6 through 29; TITLE=Developmental toxicity evaluation for benzophenone (CAS No. 119-61-9) administered by gavage to New Zealand White rabbits on gestational days 6 through 29; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5223; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=reproductive: reproductive performance-premature delivery-premature delivery|reproductive: reproductive performance-aborted-aborted; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ToxRefDB_dup_-_15708782_15708783_15708784_15708785:F:F0adult-pregnancy; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_51943776b5d9549874e6832c7eec1f11 |
| ToxValDB_ToxRefDB | NOAEL | =200 | mg/kg bw/day | Rat | oral | short-term (developmental); 14 days | developmental | LONG_REF=NTP_2002_Developmental toxicity evaluation for benzophenone (CAS No. 119-61-9) administered by gavage to Sprague-Dawley (CD) rats on gestational days 6 through 19; TITLE=Developmental toxicity evaluation for benzophenone (CAS No. 119-61-9) administered by gavage to Sprague-Dawley (CD) rats on gestational days 6 through 19; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5226; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-fetal weight; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ToxRefDB_dup_-_15708808_15708809_15708810:M/F:fetusfetal; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0f067ee7942095cee5cbee7c1a9fc935 |
ToxValDB_Uterotrophic_Hershberger_DB 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_Uterotrophic_Hershberger_DB | LEL | =300 | mg/kg bw/day | Rat | injection | short-term; 3 days | uterotrophic | LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713657:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_92f34d3693158be74659a56c734c82b5 |
| ToxValDB_Uterotrophic_Hershberger_DB | LEL | =400 | mg/kg bw/day | Rat | oral | short-term; 3 days | uterotrophic | LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713666:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1f3186023c2a226b9f593cec724f80ae |
| ToxValDB_Uterotrophic_Hershberger_DB | LEL | =500 | mg/kg bw/day | Rat | injection | short-term; 3 days | uterotrophic | LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713670:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5b0f6d3cc2218b3b5d984e8789f2662a |