NOAEL Studies
Preservative
Benzyl Alcohol NOAEL Studies
INCI: BENZYL ALCOHOL
CAS: 100-51-6
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
CIR Safety Assessment 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| CIR Safety Assessment | NOAEL | =175 | mg/kg | rat | oral | - | developmental toxicity | 5,600; 1,400; 2,800, p.10 |
| CIR Safety Assessment | NOAEL | =250 | mg/kg | rat | oral | - | developmental toxicity | 5,600; 1,400; 2,800, p.10 |
| CIR Safety Assessment | NOAEL | =300 | mg/kg body weight | rat | oral | subchronic | repeated dose toxicity | 5,600; 1,400; 2,800, p.10 |
| CIR Safety Assessment | NOAEL | >400 | mg/kg body weight | rat | oral | - | repeated dose toxicity | 800; 1,000; 3, p.9 |
| CIR Safety Assessment | NOAEL | =550 | mg/kg | rat | oral | - | developmental toxicity | 5,600; 1,400; 2,800, p.10 |
| CIR Safety Assessment | NOAEL | >750 | mg/kg | rat | oral | 16 weeks | repeated dose toxicity | 2; 5; 0, p.10 |
| CIR Safety Assessment | NOAEL | =800 | mg/kg/ day | - | oral | 2 weeks | repeated dose toxicity | 2; 61; 24, p.9 |
| CIR Safety Assessment | NOAEL | =1072 | mg/m3 | rabbit | - | 11-day | NOAEL study | 136; 96; 7, p.10 |
| CIR Safety Assessment | NOAEL | =1400 | mg/kg/day | rat | oral | 16 weeks | repeated dose toxicity | 16; 5,600; 1,400, p.10 |
COSMOS DB 10 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | LOAEL | 100 | mg/kg bw/day | mouse | oral | 2 year | Chronic | PAFA; NTP TR 343 (NIH PBL 89-2599), |
| COSMOS DB | LOAEL | 200 | mg/kg bw/day | rat | oral | 2 year | Chronic | PAFA; NTP TR 343 (NIH PBL 89-2599), |
| COSMOS DB | LOAEL | 400 | mg/kg bw/day | mouse | oral | 90 day | Subchronic | PAFA; NTP TR 343 (NIH PBL 89-2599), |
| COSMOS DB | LOAEL | 800 | mg/kg bw/day | rat | oral | 90 day | Subchronic | PAFA; NTP TR 343 (NIH PBL 89-2599), |
| COSMOS DB | NOAEL | 200 | mg/kg bw/day | mouse | oral | 735 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 400 | mg/kg bw/day | rat | oral | 735 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 500 | mg/kg bw/day | mouse | oral | 16 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 750 | mg/kg bw/day | mouse | oral | NA | Reproductive | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 800 | mg/kg bw/day | rat | oral | 91 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 1000 | mg/kg bw/day | rat | oral | 16 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
EFSA 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA | NOAEL | =400 | mg/kg bw/day | Rat | oral: gavage | 721 days | chronic/long term toxicity | EFSA FAF - 2019 - OutputID 3341 - no adverse effect observed at single/highest dose - Re-evaluation of benzyl alcohol (E 1519) as food additive - doi:10.2903/j.efsa.2019.5876 |
| EFSA | ADI | =4 | mg/kg bw/day | Consumers | - | - | ADI | EFSA FAF - 2019 - OutputID 3341 - Consumers - Re-evaluation of benzyl alcohol (E 1519) as food additive - doi:10.2903/j.efsa.2019.5876 |
| EFSA | ADI (group) | <=5 | mg/kg bw/day | Consumers | - | - | ADI (group) | EFSA CONTAM - 2011 - OutputID 586 - Consumers - Scientific Opinion on the evaluation of the substances currently on the list in the Annex to Commission Directive 96/3/EC as acceptable previous cargoes for edible fats and oils - Part I of III - doi:10.2903/j.efsa.2011.2482 |
| EFSA | NOAEL | =400 | mg/kg bw/day | Rat | oral | chronic; 103 weeks | chronic | LONG_REF=EFSA FAF (2019). Re-evaluation of benzyl alcohol (E 1519) as food additive. doi:10.2903/j.efsa.2019.5876.; TITLE=Re-evaluation of benzyl alcohol (E 1519) as food additive; AUTHOR=EFSA FAF; DOI=doi:10.2903/j.efsa.2019.5876; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2019; ORIGINAL_YEAR=2019; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15614452:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c311ae8f5463f946c3a7950709e85119 |
FDA 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| FDA | NOEL | <=750 | mg/kg bw/day | mouse (CD-1; male/female) | oral: gavage | GD 7-14 | reproductive toxicity | 7fd0287c-634a-443f-b86a-aea3e74be235_dossier.i6z - ToxicityReproduction - Oral gavage early toxicity study in CD-1 mice_1 - 8877610c-5751-410c-bce6-4439d509dcd8/4f31b79c-280e-4e94-a5b8-a2f524bed5c1 - basis: reproductive performance: no abnormal phenotype detected |
| FDA | NOEL | <=800 | mg/kg bw/day | mouse (B6C3F1; male/female) | oral: gavage | 13 weeks | repeated dose toxicity oral | 7fd0287c-634a-443f-b86a-aea3e74be235_dossier.i6z - RepeatedDoseToxicityOral - 13-week oral toxicology study in mice_4 - 765cc9fb-868a-4ef5-8009-b6b20af10184/4f31b79c-280e-4e94-a5b8-a2f524bed5c1 - basis: histopathology: non-neoplastic: no abnormal phenotype detected |
NTP ICE acute inhalation 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | LC50 | >4.178 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2767; Record_ID=acute_inhalation_620; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=4.178; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14748/7/3/3/?documentUUID=35b23fcc-78a5-4bdc-bed2-cbde0470c965; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE acute inhalation | LC50 | >5.4 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2768; Record_ID=acute_inhalation_618; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=5.4; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14748/7/3/3/?documentUUID=55897471-d480-435b-8b15-da626a37c034; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
NTP ICE acute oral 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | >1230 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_64; row=8434; data_type=In Vivo; mixture=Chemical; chemical_name=Benzyl alcohol; preferred_name=Benzyl alcohol; dtxsid=DTXSID5020152; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5020152; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | <3120 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_67; row=8435; data_type=In Vivo; mixture=Chemical; chemical_name=Benzyl alcohol; preferred_name=Benzyl alcohol; dtxsid=DTXSID5020152; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5020152; source_file=acute_oral.xlsx |
NTP ICE cancer 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE cancer | Top dose | 200 | mg/kg bw/day | Mouse | Gavage | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=5273; Record_ID=cancer_186; Data_Type=In Vivo; Formulation_Name=Benzyl Alcohol; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=200; Response_Unit=mg/kg/day; Species=Mouse; Strain=B6C3F1; Sex=Male; Route=Gavage; Reference=TR-343; URL=https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr343/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE cancer | Top dose | 400 | mg/kg bw/day | Rat | Gavage | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=5274; Record_ID=cancer_190; Data_Type=In Vivo; Formulation_Name=Benzyl Alcohol; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=400; Response_Unit=mg/kg/day; Species=Rat; Strain=F344/N; Sex=Female; Route=Gavage; Reference=TR-343; URL=https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr343/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
NTP ICE endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=5400; RecordID=ARPathway2016_399; DatasetName=ARPathway2016; DTXSID=DTXSID5020152; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
NTP ICE eye irritation 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE eye irritation | Draize rabbit irritation score | 31 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=1464; Record_ID=eye_irritation_139; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=31; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE eye irritation | EPA Classification | 1 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=1458; Record_ID=eye_irritation_139; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=1; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE eye irritation | GHS Classification | 2 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=1459; Record_ID=eye_irritation_139; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=2; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE eye irritation | Intensity | 0.27 | %/sec | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=1461; Record_ID=eye_irritation_1283; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=Vitrigel; Endpoint=Intensity; Response=0.27; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE eye irritation | Lag time | 0 | s | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=1462; Record_ID=eye_irritation_1283; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=Vitrigel; Endpoint=Lag time; Response=0; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE eye irritation | Plateau level | 49 | % | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=1463; Record_ID=eye_irritation_1283; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=Vitrigel; Endpoint=Plateau level; Response=49; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
NTP ICE skin irritation 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin irritation | Positive reaction | 3.2 | % | Human | Dermal | - | In Vivo; Four-hour Human Patch Test | sheet=Data_invivo; excel_row=998; Record_ID=skin_irritation_invivo_32; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=Four-hour Human Patch Test; Endpoint=Positive reaction; Response=3.2; Response_Unit=%; Species=Human; Reference=Basketter et al. 2004; 15291823; 10.1111/j.0105-1873.2004.00385.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE skin irritation | Viability | 72.46 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=3446; Record_ID=skin_irritation_invitro_247; Data_Type=In Vitro; Formulation_Name=Benzyl alcohol; Concentration=99; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=EpiSkin Irritation; Endpoint=Viability; Response=72.46; Response_Unit=%; Reference=Cotovio et al. 2005; 16185103; 10.1177/026119290503300403; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE skin irritation | Viability | 75.1 | % | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=3448; Record_ID=skin_irritation_invitro_249; Data_Type=In Vitro; Formulation_Name=Benzylalcohol; Concentration=99; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=EpiDerm Irritation; Endpoint=Viability; Response=75.10; Response_Unit=%; Reference=Kandarova et al. 2005; 16185104; 10.1177/026119290503300408; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE skin irritation | Viability | 79.62 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=3447; Record_ID=skin_irritation_invitro_248; Data_Type=In Vitro; Formulation_Name=Benzyl alcohol; Concentration=99; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=EpiSkin Irritation; Endpoint=Viability; Response=79.62; Response_Unit=%; Reference=Cotovio et al. 2005; 16185103; 10.1177/026119290503300403; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE skin irritation | Viability | 93.8 | % | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=3449; Record_ID=skin_irritation_invitro_250; Data_Type=In Vitro; Formulation_Name=Benzylalcohol; Concentration=99; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=EpiDerm Irritation; Endpoint=Viability; Response=93.8; Response_Unit=%; Reference=Kandarova et al. 2005; 16185104; 10.1177/026119290503300408; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE skin irritation | Viability | 98.6 | % | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=3450; Record_ID=skin_irritation_invitro_251; Data_Type=In Vitro; Formulation_Name=Benzylalcohol; Concentration=99; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=EpiDerm Irritation; Endpoint=Viability; Response=98.6; Response_Unit=%; Reference=Kandarova et al. 2005; 16185104; 10.1177/026119290503300408; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE skin irritation | Viability (18 hours) | 85.1 | % | - | Dermal | - | In Vitro; Vitrolife-Skin Irritation | sheet=Data_invitro; excel_row=3442; Record_ID=skin_irritation_invitro_199; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=Vitrolife-Skin Irritation; Endpoint=Viability (18 hours); Response=85.1; Response_Unit=%; Reference=Morikawa et al. 2008; Not available; 10.11232/AATEX.13.11; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE skin irritation | Viability (42 hours) | 98.7 | % | - | Dermal | - | In Vitro; Vitrolife-Skin Irritation | sheet=Data_invitro; excel_row=3444; Record_ID=skin_irritation_invitro_199; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=Vitrolife-Skin Irritation; Endpoint=Viability (42 hours); Response=98.7; Response_Unit=%; Reference=Morikawa et al. 2008; Not available; 10.11232/AATEX.13.11; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
NTP ICE skin sensitization 31 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | CD86, EC150 | 766.6 | ug/mL | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; h-CLAT | sheet=Data_invitro; excel_row=1674; Record_ID=skin_sensitization_invitro_396; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=766.6; Reported_Response_Unit=ug/mL; Response=766.6; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE skin sensitization | CV75 | 1000 | ug/mL | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; h-CLAT | sheet=Data_invitro; excel_row=1642; Record_ID=skin_sensitization_invitro_396; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=h-CLAT; Endpoint=CV75; Reported_Response=1000; Reported_Response_Unit=ug/mL; Response=1000; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE skin sensitization | Concentration, 5% incidence of positive responses | range6.9 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=1545; Record_ID=skin_sensitization_invivo_518; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=15.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response_Modifier=range; Response=6.9 - 8.6; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 2003; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Scognamiglio et al. 2012; 22036973; 10.1016/j.fct.2011.10.013|Api et al. 2015; 26364874; 10.1016/j.fct.2015.09.005|Api et al. 2017; 28691948; 10.1097/der.0000000000000304|Api et al. 2019; 31568852; 10.1016/j.fct.2019.110842; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE skin sensitization | Concentration, 5% incidence of positive responses | range11.2 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=1513; Record_ID=skin_sensitization_invivo_513; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response_Modifier=range; Response=11.2 - 56; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 2002; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Scognamiglio et al. 2012; 22036973; 10.1016/j.fct.2011.10.013|Api et al. 2015; 26364874; 10.1016/j.fct.2015.09.005|Api et al. 2017; 28691948; 10.1097/der.0000000000000304|Api et al. 2019; 31568852; 10.1016/j.fct.2019.110842; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE skin sensitization | Concentration, 5% incidence of positive responses | range13.75 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=1531; Record_ID=skin_sensitization_invivo_514; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=7.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response_Modifier=range; Response=13.75 - 41.25; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 2004; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Scognamiglio et al. 2012; 22036973; 10.1016/j.fct.2011.10.013|Api et al. 2015; 26364874; 10.1016/j.fct.2015.09.005|Api et al. 2017; 28691948; 10.1097/der.0000000000000304|Api et al. 2019; 31568852; 10.1016/j.fct.2019.110842; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE skin sensitization | Concentration, one positive response | range2.5 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=1525; Record_ID=skin_sensitization_invivo_514; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=7.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response_Modifier=range; Response=2.5 - 7.5; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 2004; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Scognamiglio et al. 2012; 22036973; 10.1016/j.fct.2011.10.013|Api et al. 2015; 26364874; 10.1016/j.fct.2015.09.005|Api et al. 2017; 28691948; 10.1097/der.0000000000000304|Api et al. 2019; 31568852; 10.1016/j.fct.2019.110842; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE skin sensitization | Depletion Cys | 2.1 | % | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; DPRA | sheet=Data_invitro; excel_row=250; Record_ID=skin_sensitization_invitro_69; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=2.1; Reported_Response_Unit=%; Response=2.1; Response_Unit=%; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE skin sensitization | Depletion Lys | 8 | % | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; DPRA | sheet=Data_invitro; excel_row=223; Record_ID=skin_sensitization_invitro_69; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=8; Reported_Response_Unit=%; Response=8; Response_Unit=%; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE skin sensitization | EC1.5 | <964.51 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=8019; Record_ID=skin_sensitization_invitro_1813; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=LuSens; Endpoint=EC1.5; Response_Modifier=<; Reported_Response_Modifier=<; Reported_Response=964.51; Reported_Response_Unit=uM; Response=964.51; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE skin sensitization | EC1.5 | >2000 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=3933; Record_ID=skin_sensitization_invitro_903; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=KeratinoSens; Endpoint=EC1.5; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE skin sensitization | EC1.5 | 4000 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; KeratinoSens | sheet=Data_invitro; excel_row=3934; Record_ID=skin_sensitization_invitro_904; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=4000; Reported_Response_Unit=uM; Response=4000; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE skin sensitization | IC50 | >2400 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7645; Record_ID=skin_sensitization_invitro_1813; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=LuSens; Endpoint=IC50; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2400; Reported_Response_Unit=uM; Response=2400; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE skin sensitization | Imax | 1.23 | ratio | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=3938; Record_ID=skin_sensitization_invitro_903; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.23; Reported_Response_Unit=Unitless; Response=1.23; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE skin sensitization | Imax | 1.232 | ratio | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; KeratinoSens | sheet=Data_invitro; excel_row=3939; Record_ID=skin_sensitization_invitro_904; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.23155; Reported_Response_Unit=Unitless; Response=1.232; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE skin sensitization | Imax | 1.929 | ratio | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7547; Record_ID=skin_sensitization_invitro_1813; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=LuSens; Endpoint=Imax; Reported_Response=1.929002165; Reported_Response_Unit=Unitless; Response=1.929; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE skin sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=1508; Record_ID=skin_sensitization_invivo_511; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1970: report to RIFM|RIFM 1970; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1973; Not available; 10.1016/0015-6264(73)90228-9|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425|Api et al. 2017; 28691948; 10.1097/der.0000000000000304; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE skin sensitization | Incidence of positive responses | range0.9 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=1521; Record_ID=skin_sensitization_invivo_514; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=7.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response_Modifier=range; Response=0.9 - 2.7; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 2004; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Scognamiglio et al. 2012; 22036973; 10.1016/j.fct.2011.10.013|Api et al. 2015; 26364874; 10.1016/j.fct.2015.09.005|Api et al. 2017; 28691948; 10.1097/der.0000000000000304|Api et al. 2019; 31568852; 10.1016/j.fct.2019.110842; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE skin sensitization | Incidence of positive responses | range1.8 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=1553; Record_ID=skin_sensitization_invivo_513; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response_Modifier=range; Response=1.8 - 8.9; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 2002; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Scognamiglio et al. 2012; 22036973; 10.1016/j.fct.2011.10.013|Api et al. 2015; 26364874; 10.1016/j.fct.2015.09.005|Api et al. 2017; 28691948; 10.1097/der.0000000000000304|Api et al. 2019; 31568852; 10.1016/j.fct.2019.110842; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE skin sensitization | Incidence of positive responses | range8.7 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=1538; Record_ID=skin_sensitization_invivo_518; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=15.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response_Modifier=range; Response=8.7 - 10.9; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 2003; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Scognamiglio et al. 2012; 22036973; 10.1016/j.fct.2011.10.013|Api et al. 2015; 26364874; 10.1016/j.fct.2015.09.005|Api et al. 2017; 28691948; 10.1097/der.0000000000000304|Api et al. 2019; 31568852; 10.1016/j.fct.2019.110842; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE skin sensitization | Induction dose per skin area | 3543 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=1512; Record_ID=skin_sensitization_invivo_512; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=3.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=3543; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 2004; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Scognamiglio et al. 2012; 22036973; 10.1016/j.fct.2011.10.013|Api et al. 2015; 26364874; 10.1016/j.fct.2015.09.005|Api et al. 2017; 28691948; 10.1097/der.0000000000000304|Api et al. 2019; 31568852; 10.1016/j.fct.2019.110842; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE skin sensitization | Induction dose per skin area | 6480 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=1505; Record_ID=skin_sensitization_invivo_511; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=6480; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1970: report to RIFM|RIFM 1970; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1973; Not available; 10.1016/0015-6264(73)90228-9|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425|Api et al. 2017; 28691948; 10.1097/der.0000000000000304; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE skin sensitization | Induction dose per skin area | 8858 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=1519; Record_ID=skin_sensitization_invivo_514; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=7.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=8858; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 2004; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Scognamiglio et al. 2012; 22036973; 10.1016/j.fct.2011.10.013|Api et al. 2015; 26364874; 10.1016/j.fct.2015.09.005|Api et al. 2017; 28691948; 10.1097/der.0000000000000304|Api et al. 2019; 31568852; 10.1016/j.fct.2019.110842; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE skin sensitization | Induction dose per skin area | 17720 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=1536; Record_ID=skin_sensitization_invivo_518; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=15.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=17720; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 2003; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Scognamiglio et al. 2012; 22036973; 10.1016/j.fct.2011.10.013|Api et al. 2015; 26364874; 10.1016/j.fct.2015.09.005|Api et al. 2017; 28691948; 10.1097/der.0000000000000304|Api et al. 2019; 31568852; 10.1016/j.fct.2019.110842; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE skin sensitization | Induction dose per skin area | 23620 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=1551; Record_ID=skin_sensitization_invivo_513; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=23620; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 2002; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Scognamiglio et al. 2012; 22036973; 10.1016/j.fct.2011.10.013|Api et al. 2015; 26364874; 10.1016/j.fct.2015.09.005|Api et al. 2017; 28691948; 10.1097/der.0000000000000304|Api et al. 2019; 31568852; 10.1016/j.fct.2019.110842; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE skin sensitization | Induction dose per skin area, 5% incidence of positive responses | range8150 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=1547; Record_ID=skin_sensitization_invivo_518; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=15.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response_Modifier=range; Response=8150 - 10187; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 2003; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Scognamiglio et al. 2012; 22036973; 10.1016/j.fct.2011.10.013|Api et al. 2015; 26364874; 10.1016/j.fct.2015.09.005|Api et al. 2017; 28691948; 10.1097/der.0000000000000304|Api et al. 2019; 31568852; 10.1016/j.fct.2019.110842; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE skin sensitization | Induction dose per skin area, 5% incidence of positive responses | range13228 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=1515; Record_ID=skin_sensitization_invivo_513; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response_Modifier=range; Response=13228 - 66142; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 2002; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Scognamiglio et al. 2012; 22036973; 10.1016/j.fct.2011.10.013|Api et al. 2015; 26364874; 10.1016/j.fct.2015.09.005|Api et al. 2017; 28691948; 10.1097/der.0000000000000304|Api et al. 2019; 31568852; 10.1016/j.fct.2019.110842; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE skin sensitization | Induction dose per skin area, 5% incidence of positive responses | range16240 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=1533; Record_ID=skin_sensitization_invivo_514; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=7.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response_Modifier=range; Response=16240 - 48719; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 2004; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Scognamiglio et al. 2012; 22036973; 10.1016/j.fct.2011.10.013|Api et al. 2015; 26364874; 10.1016/j.fct.2015.09.005|Api et al. 2017; 28691948; 10.1097/der.0000000000000304|Api et al. 2019; 31568852; 10.1016/j.fct.2019.110842; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE skin sensitization | Induction dose per skin area, one positive response | range2953 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=1527; Record_ID=skin_sensitization_invivo_514; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=7.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, one positive response; Response_Modifier=range; Response=2953 - 8858; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 2004; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Scognamiglio et al. 2012; 22036973; 10.1016/j.fct.2011.10.013|Api et al. 2015; 26364874; 10.1016/j.fct.2015.09.005|Api et al. 2017; 28691948; 10.1097/der.0000000000000304|Api et al. 2019; 31568852; 10.1016/j.fct.2019.110842; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE skin sensitization | Induction dose per skin area, one positive response | range4724 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=1559; Record_ID=skin_sensitization_invivo_513; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, one positive response; Response_Modifier=range; Response=4724 - 23622; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 2002; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Scognamiglio et al. 2012; 22036973; 10.1016/j.fct.2011.10.013|Api et al. 2015; 26364874; 10.1016/j.fct.2015.09.005|Api et al. 2017; 28691948; 10.1097/der.0000000000000304|Api et al. 2019; 31568852; 10.1016/j.fct.2019.110842; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE skin sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=1511; Record_ID=skin_sensitization_invivo_511; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1970: report to RIFM|RIFM 1970; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1973; Not available; 10.1016/0015-6264(73)90228-9|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425|Api et al. 2017; 28691948; 10.1097/der.0000000000000304; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
| NTP ICE skin sensitization | Relative reliability score | 4 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=1517; Record_ID=skin_sensitization_invivo_513; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5020152; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=4; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=RIFM 2002; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Scognamiglio et al. 2012; 22036973; 10.1016/j.fct.2011.10.013|Api et al. 2015; 26364874; 10.1016/j.fct.2015.09.005|Api et al. 2017; 28691948; 10.1097/der.0000000000000304|Api et al. 2019; 31568852; 10.1016/j.fct.2019.110842; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020152; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020152 |
EPA ToxRefDB v3 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA ToxRefDB v3 | LEL | =200 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 13 week | SUB | study_id=5468; toxval_study_source_id=studyid5468_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-clinical signs-labored respiration|in life observation-clinical signs-unsteady gait|pathology microscopic-brain-necrosis|in life observation-clinical signs-lethargy; dose_level=3; study_year=1989; study_citation=(1989). 'NTP Toxicology and Carcinogenesis Studies of Benzyl Alcohol (CAS No. 100-51-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies).' Natl Toxicol Program Tech Rep Ser 343: 1-158. (Subchronic rat); dsstox_substance_id=DTXSID5020152; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =400 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 13 week | SUB | study_id=5469; toxval_study_source_id=studyid5469_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-clinical signs-unsteady gait; dose_level=4; study_year=1989; study_citation=(1989). 'NTP Toxicology and Carcinogenesis Studies of Benzyl Alcohol (CAS No. 100-51-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies).' Natl Toxicol Program Tech Rep Ser 343: 1-158. (Subchronic mouse); dsstox_substance_id=DTXSID5020152; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =800 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 13 week | SUB | study_id=5468; toxval_study_source_id=studyid5468_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-thymus-hemorrhage|in life observation-clinical signs-labored respiration|in life observation-clinical signs-unsteady gait|in life observation-clinical signs-lethargy|pathology microscopic-brain-necrosis|in life observation-clinical signs-blood around eyes and nose|pathology microscopic-thymus-atrophy|pathology microscopic-kidney-nephropathy|pathology microscopic-thymus-congestion|in life observation-body weight-body weight|in life observation-mortality-mortality|pathology microscopic-skeletal muscle-necrosis; dose_level=5; study_year=1989; study_citation=(1989). 'NTP Toxicology and Carcinogenesis Studies of Benzyl Alcohol (CAS No. 100-51-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies).' Natl Toxicol Program Tech Rep Ser 343: 1-158. (Subchronic rat); dsstox_substance_id=DTXSID5020152; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =400 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 13 week | SUB | study_id=5468; toxval_study_source_id=studyid5468_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight; dose_level=4; study_year=1989; study_citation=(1989). 'NTP Toxicology and Carcinogenesis Studies of Benzyl Alcohol (CAS No. 100-51-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies).' Natl Toxicol Program Tech Rep Ser 343: 1-158. (Subchronic rat); dsstox_substance_id=DTXSID5020152; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =800 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 13 week | SUB | study_id=5469; toxval_study_source_id=studyid5469_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-unsteady gait|in life observation-body weight-body weight; dose_level=5; study_year=1989; study_citation=(1989). 'NTP Toxicology and Carcinogenesis Studies of Benzyl Alcohol (CAS No. 100-51-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies).' Natl Toxicol Program Tech Rep Ser 343: 1-158. (Subchronic mouse); dsstox_substance_id=DTXSID5020152; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | >0 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 2 year | CHR | study_id=5470; toxval_study_source_id=studyid5470_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-lung-foreign body|in life observation-mortality-mortality|pathology microscopic-eye-atrophy|pathology microscopic-lung-hemorrhage|pathology microscopic-eye-cataract; dose_level=0; study_year=1989; study_citation=(1989). 'NTP Toxicology and Carcinogenesis Studies of Benzyl Alcohol (CAS No. 100-51-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies).' Natl Toxicol Program Tech Rep Ser 343: 1-158. (Chronic rat); dsstox_substance_id=DTXSID5020152; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =100 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 13 week | SUB | study_id=5468; toxval_study_source_id=studyid5468_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-lethargy|pathology microscopic-brain-necrosis|in life observation-clinical signs-unsteady gait|in life observation-clinical signs-labored respiration|in life observation-body weight-body weight; dose_level=2; study_year=1989; study_citation=(1989). 'NTP Toxicology and Carcinogenesis Studies of Benzyl Alcohol (CAS No. 100-51-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies).' Natl Toxicol Program Tech Rep Ser 343: 1-158. (Subchronic rat); dsstox_substance_id=DTXSID5020152; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =200 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 13 week | SUB | study_id=5469; toxval_study_source_id=studyid5469_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-unsteady gait|in life observation-body weight-body weight; dose_level=3; study_year=1989; study_citation=(1989). 'NTP Toxicology and Carcinogenesis Studies of Benzyl Alcohol (CAS No. 100-51-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies).' Natl Toxicol Program Tech Rep Ser 343: 1-158. (Subchronic mouse); dsstox_substance_id=DTXSID5020152; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ECHA 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LEL | =100 | mg/kg bw/day | Rat | dermal | short-term; 2 weeks | short-term | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61df9e4b096bca8777da5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=4f31b79c-280e-4e94-a5b8-a2f524bed5c1; TOXICOLOGICAL_EFFECT=skin inflammation|Two week repeat dose dermal toxicology studies were conducted in rats and dogs with the lice asphyxiator drug product. Doses of 0 (untreated control), 0% (vehicle), 5% (100 mg/kg/day), 10% (200 mg/kg/day) and 15% (300 mg/kg/day) lice asphyxiator drug product were used in both studies. Lice asphyxiator drug product was applied for 6 hours/day in both studies. The lice asphyxiator drug product was applied under occlusion in the rat study. The 5% lice asphyxiator drug product caused minor dermal irritation in both rats and dogs after 2 weeks of repeat dermal exposure (6 hours/day). Both of these studies applied the lice asphyxiator drug product for 6 hours/day for two weeks. In addition, the rat study was conducted under occlusive conditions. Therefore, the conduct of both the rat and dog studies were under exaggerated use conditions compared to the proposed clinical use. The clinical use of the lice asphyxiator drug product will be to apply two ten minute applications of drug product separated by at least one week. The duration and extent of dermal exposure to the lice asphyxiator drug product under conditions of clinical use is much less than was used in the two week dermal toxicology studies conducted in rats and dogs. Negligible plasma concentrations of benzyl alcohol were detected in the low, mid and high dose groups in the 2 week dermal rat toxicology study. Samples were quantifiable in only the one hour post-dose sample in the mid and high dose groups. The mean one hour plasma concentrations (ug/ml) of benzyl alcohol in rats following daily application of the lice asphyxiator drug product are provided in the following table. A dose dependent increase in the mean one hour plasma concentrations was noted for the mid and high dose groups. In addition, concentrations increased 1.6 to 3.8 fold after multiple dosing. No apparent gender effect on the mean one hour plasma concentrations was noted in this study. The highest benzyl alcohol exposure was observed in high dose male rats on day 14 with a mean one hour plasma concentration of 3.59 ug/ml. A dose dependent increase in the mean one hour plasma concentrations was noted for male animals, but not female animals, on day 14. The mean one hour benzyl alcohol plasma concentrations increased between 3-12 fold following 14 days of dosing. No apparent gender effect on the mean one hour plasma concentrations was noted in the low and mid dose groups. An apparent gender effect on the mean one hour plasma concentrations was noted in the high dose group. This may be more of a factor related to an unusually low value in high dose females on days 1 and 14. The highest benzyl alcohol exposure was observed in high dose male dogs on day 14 with a mean one hour plasma concentration of 10.2 ug/ml.; STUDY_GROUP=ECHA IUCLID:15826369:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4a477d8135fb04660f0f64208322cc47 |
| ECHA | LEL | >=200 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaca9e4b0a7c65d1c023d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=4f31b79c-280e-4e94-a5b8-a2f524bed5c1; TOXICOLOGICAL_EFFECT=body weight and weight gain: decreased susceptibility to weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID:15837452:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_054c991a709adc2f076f17d39d7852a7 |
| ECHA | LEL | >=400 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaca9e4b0a7c65d1c023d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=4f31b79c-280e-4e94-a5b8-a2f524bed5c1; TOXICOLOGICAL_EFFECT=body weight and weight gain: decreased susceptibility to weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID:15837453:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5e29522071d056dd7d856a7ec2f2a16b |
| ECHA | LEL | =800 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaca9e4b0a7c65d1c023f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=4f31b79c-280e-4e94-a5b8-a2f524bed5c1; TOXICOLOGICAL_EFFECT=clinical signs: lethargy|clinical signs: respiratory distress|clinical signs: staggering gait; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECHA IUCLID:15846070:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8acb5432c0a4ce712fc3ec9f0beea828 |
| ECHA | LOAEL | <=800 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaca9e4b0a7c65d1c023d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=4f31b79c-280e-4e94-a5b8-a2f524bed5c1; TOXICOLOGICAL_EFFECT=histopathology: non-neoplastic: no abnormal phenotype detected; STUDY_GROUP=ECHA IUCLID:15837451:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d00615ec37b669a96577601892276d4f |
ToxValDB ECOTOX 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =300 | mg/kg bw/day | Rat | oral | short-term; 2 days | short-term | LONG_REF=Mutat. Res.320(3): 189-205 Uno,Y., H. Takasawa, M. Miyagawa, Y. Inoue, T. Murata, and K. Yoshikawa An In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test Using Rat Hepatocytes as an Early Prediction Assay for Nongenotoxic Hepatocarcinogens Screening of 22 Known Positive and 25 Noncarcinogens 1994; TITLE=An In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test Using Rat Hepatocytes as an Early Prediction Assay for Nongenotoxic Hepatocarcinogens Screening of 22 Known Positive and 25 Noncarcinogens; AUTHOR=Uno,Y., H. Takasawa, M. Miyagawa, Y. Inoue, T. Murata, and K. Yoshikawa; DOI=10.1016/0165-1218(94)90046-9; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75058; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Cell(s): Viability; STUDY_GROUP=ECOTOX:15595776:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=62393a8660e02810c35e7cafff27a079 |
| ToxValDB ECOTOX | LOEL | =600 | mg/kg bw/day | Rat | oral | acute; 1 days | acute | LONG_REF=Mutat. Res.320(3): 189-205 Uno,Y., H. Takasawa, M. Miyagawa, Y. Inoue, T. Murata, and K. Yoshikawa An In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test Using Rat Hepatocytes as an Early Prediction Assay for Nongenotoxic Hepatocarcinogens Screening of 22 Known Positive and 25 Noncarcinogens 1994; TITLE=An In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test Using Rat Hepatocytes as an Early Prediction Assay for Nongenotoxic Hepatocarcinogens Screening of 22 Known Positive and 25 Noncarcinogens; AUTHOR=Uno,Y., H. Takasawa, M. Miyagawa, Y. Inoue, T. Murata, and K. Yoshikawa; DOI=10.1016/0165-1218(94)90046-9; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75058; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Cell(s): Viability; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598994_15598995:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e864a2984683381032d686cb6cef911f |
| ToxValDB ECOTOX | NOEL | =25 | mg/kg bw/day | Mouse | injection | short-term; 19 days | short-term | LONG_REF=Food Chem. Toxicol.41(3): 439-446 Larsen,S.T., R.M. Lund, P. Thygesen, O.M. Poulsen, and G.D. Nielsen Investigation of the Adjuvant and Immuno-Suppressive Effects of Benzyl Butyl Phthalate, Phthalic Acid and Benzyl Alcohol in a Murine Injection Model 2003; TITLE=Investigation of the Adjuvant and Immuno-Suppressive Effects of Benzyl Butyl Phthalate, Phthalic Acid and Benzyl Alcohol in a Murine Injection Model; AUTHOR=Larsen,S.T., R.M. Lund, P. Thygesen, O.M. Poulsen, and G.D. Nielsen; DOI=10.1016/s0278-6915(02)00248-x; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=91884; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=Immunological: immunoglobulin E; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594413_15602332:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=9975bf8031dbbb7dee5d82ddc9bf9983 |
| ToxValDB ECOTOX | NOEL | =300 | mg/kg bw/day | Rat | oral | acute; 1 days | acute | LONG_REF=Mutat. Res.320(3): 189-205 Uno,Y., H. Takasawa, M. Miyagawa, Y. Inoue, T. Murata, and K. Yoshikawa An In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test Using Rat Hepatocytes as an Early Prediction Assay for Nongenotoxic Hepatocarcinogens Screening of 22 Known Positive and 25 Noncarcinogens 1994; TITLE=An In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test Using Rat Hepatocytes as an Early Prediction Assay for Nongenotoxic Hepatocarcinogens Screening of 22 Known Positive and 25 Noncarcinogens; AUTHOR=Uno,Y., H. Takasawa, M. Miyagawa, Y. Inoue, T. Murata, and K. Yoshikawa; DOI=10.1016/0165-1218(94)90046-9; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75058; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Cell(s): Viability; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598994_15598995:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=773767f0454de9a1b751eb693d6f6733 |
| ToxValDB ECOTOX | NOEL | =800 | mg/kg bw/day | Mouse | oral | short-term; 2 days | short-term | LONG_REF=Mutat. Res.343(2/3): 157-183 Miyagawa,M., H. Takasawa, A. Sugiyama, Y. Inoue, T. Murata, Y. Uno, and K. Yoshikawa The In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test with Hepatocytes Prepared from Male B6C3F1 Mice as an Early Prediction Assay for Putative Nongenotoxic (Ames-Negative) Mouse Hepatocarcinogens 1995; TITLE=The In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test with Hepatocytes Prepared from Male B6C3F1 Mice as an Early Prediction Assay for Putative Nongenotoxic (Ames-Negative) Mouse Hepatocarcinogens; AUTHOR=Miyagawa,M., H. Takasawa, A. Sugiyama, Y. Inoue, T. Murata, Y. Uno, and K. Yoshikawa; DOI=10.1016/0165-1218(95)90082-9; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=75052; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Cell(s): Viability; STUDY_GROUP=ECOTOX:15595608:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1c7e6213dcb69485cd53cc57e88ce608 |
ToxValDB GESTIS DNEL 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =22 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15630054_15630055:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_32c762f727de6b177193f5e015fd6a47 |
| ToxValDB GESTIS DNEL | DNEL systemic | =25.8 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15630054_15630055:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_997b6c4431d4331d45e7224f841af73d |
ToxValDB PPRTV (CPHEA) 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB PPRTV (CPHEA) | NOAEL (ADJ) | =143 | mg/kg bw/day | Mouse | oral | chronic; 2 years | chronic | LONG_REF=NTP 1989a; AUTHOR=NTP; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b361; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1593; TOXICOLOGICAL_EFFECT=survival, growth, and tissue histopathology; TOXICOLOGICAL_EFFECT_CATEGORY=multiple; STUDY_GROUP=PPRTV (CPHEA):15654034:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c9a9d6e708400fadafba491fe3b98ef1 |
| ToxValDB PPRTV (CPHEA) | NOAEL (ADJ) | =286 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP 1989a; AUTHOR=NTP; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b361; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1593; TOXICOLOGICAL_EFFECT=clinical signs of neurotoxicity, such as staggering, labored breathing, and lethargy; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=PPRTV (CPHEA):15654080:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3a60e5c34c9aa50e0f50e2939f76a034 |
| ToxValDB PPRTV (CPHEA) | RfD (provisional) | =0.3 | mg/kg bw/day | Human | oral | - | Toxicity Value | LONG_REF=NTP 1989a; AUTHOR=NTP; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b361; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1593; TOXICOLOGICAL_EFFECT=Clinical signs of neurotoxicity, such as staggering, labored breathing, and lethargy. in male/female mice; STUDY_GROUP=PPRTV (CPHEA)_dup_PPRTV Summary_15653622_15653686:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f1a3ef9dd864d4f3822e93f800b59b87 |
ToxValDB Pennsylvania DEP ToxValues 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Pennsylvania DEP ToxValues | RfD | =0.1 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67599fbae4b0a7c65d37b2e3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://files.dep.state.pa.us/EnvironmentalCleanupBrownfields/LandRecyclingProgram/LandRecyclingProgramPortalFiles/GuidanceTechTools/VaporIntrusion/November_2021/Table%205a.pdf; STUDY_GROUP=Pennsylvania DEP ToxValues:15649838:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a34819788c9dbd89c7b067f06ee49207 |
ToxValDB ToxRefDB 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ToxRefDB | LEL | =200 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | LONG_REF=(1989). \'NTP Toxicology and Carcinogenesis Studies of Benzyl Alcohol (CAS No. 100-51-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies).\' Natl Toxicol Program Tech Rep Ser 343: 1-158. (Chronic rat); TITLE=NTP Toxicology and Carcinogenesis Studies of Benzyl Alcohol (CAS No. 100-51-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies); AUTHOR=NTP; EXTERNAL_SOURCE_ID=5470; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=systemic: in life observation-mortality-mortality|systemic: pathology microscopic-lung-foreign body|systemic: pathology microscopic-lung-hemorrhage|systemic: pathology microscopic-eye-cataract|systemic: pathology microscopic-eye-atrophy; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB:15709329:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b715f26fd1b010ad001ad1ba6674c40a |
| ToxValDB ToxRefDB | LOAEL | =400 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=(1989). \'NTP Toxicology and Carcinogenesis Studies of Benzyl Alcohol (CAS No. 100-51-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies).\' Natl Toxicol Program Tech Rep Ser 343: 1-158. (Subchronic rat); TITLE=NTP Toxicology and Carcinogenesis Studies of Benzyl Alcohol (CAS No. 100-51-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies); AUTHOR=NTP; EXTERNAL_SOURCE_ID=5468; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15709315_15709316_15709317_15709318:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_103ba189ed3212bb58bdc79f9050ab5e |
| ToxValDB ToxRefDB | NEL | =100 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=(1989). \'NTP Toxicology and Carcinogenesis Studies of Benzyl Alcohol (CAS No. 100-51-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies).\' Natl Toxicol Program Tech Rep Ser 343: 1-158. (Subchronic rat); TITLE=NTP Toxicology and Carcinogenesis Studies of Benzyl Alcohol (CAS No. 100-51-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies); AUTHOR=NTP; EXTERNAL_SOURCE_ID=5468; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-brain-necrosis|systemic: in life observation-clinical signs-lethargy|systemic: in life observation-clinical signs-labored respiration|systemic: in life observation-clinical signs-unsteady gait|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15709315_15709316_15709317_15709318:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a04c4f6c9327f6cedf39df8b264f2ed9 |
Regulatory source 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | - | 1072 | mg/m3 | rabbit | - | 11-day | - | p.10 |
| Regulatory source | developmental toxicity | 175 | mg/kg | rat | oral | - | developmental toxicity | p.10 |
| Regulatory source | developmental toxicity | 250 | mg/kg | rat | oral | - | developmental toxicity | p.10 |
| Regulatory source | developmental toxicity | 550 | mg/kg | rat | oral | - | developmental toxicity | p.10 |
| Regulatory source | repeated dose toxicity | 300 | mg/kg body weight | rat | oral | subchronic | repeated dose toxicity | p.10 |
| Regulatory source | repeated dose toxicity | >400 | mg/kg body weight | rat | oral | - | repeated dose toxicity | p.9 |
| Regulatory source | repeated dose toxicity | >750 | mg/kg | rat | oral | 16 weeks | repeated dose toxicity | p.10 |
| Regulatory source | repeated dose toxicity | 800 | mg/kg/ day | - | oral | 2 weeks | repeated dose toxicity | p.9 |
| Regulatory source | repeated dose toxicity | 1400 | mg/kg/day | rat | oral | 16 weeks | repeated dose toxicity | p.10 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | LKG8494WBH | UNII | - | - | - | chemical | - |