Is Bergenin safe in cosmetics?
Bergenin has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted.
Moderate
Cosmetic Ingredient
Bergenin
Also known as: UNII-L84RBE4IDC, (2R,3S,4S,4aR,10bS)-3,4,8,10-Tetrahydroxy-2-(hydroxymethyl)-9-methoxy-3,4,4a,10b-tetrahydropyrano[3,2-c]isochromen-6(2H)-one, Cuscutin
INCI: BERGENIN
Bergenin (CAS 477-90-7) is a cosmetic cosmetic ingredient functioning as Skin conditioning (antioxidant, anti-inflammatory, wound healing); C-glucoside. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 477-90-7 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning (antioxidant, anti-inflammatory, wound healing); C-glucoside of 4-O-methyl gallic acid
Safety Rating
MODERATE
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
No FDA monograph; no CIR review; not GRAS-listed
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Bergenin.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Bergenin.
Known Synonyms
UNII-L84RBE4IDC
(2R,3S,4S,4aR,10bS)-3,4,8,10-Tetrahydroxy-2-(hydroxymethyl)-9-methoxy-3,4,4a,10b-tetrahydropyrano[3,2-c]isochromen-6(2H)-one
Cuscutin
Chemical Function
Softener and conditioner
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
BERGENIN
ChEMBL ID
CHEMBL273019
Max Phase
-1
Frequently Asked Questions
Is Bergenin allowed in the EU?
Bergenin EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Bergenin do in cosmetics?
Bergenin functions as: Skin conditioning (antioxidant, anti-inflammatory, wound healing); C-glucoside of 4-O-methyl gallic acid. It is classified as a cosmetic ingredient in our database. CAS number: 477-90-7.
Is Bergenin used outside cosmetics?
Bergenin also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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