NOAEL Studies Active Ingredient

Beta-Arbutin NOAEL Studies

INCI: BETA-ARBUTIN

CAS: 497-76-7

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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SCCS Opinion 20 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =1000 mg/kg bw/day rat oral Sub-chronic repeated dose toxicity p.17
SCCS Opinion NOAEL =618 mg/kg bw/day - oral 28 day NOAEL study p.18
SCCS Opinion NOAEL =400 mg/kg bw/day rat - 28 day repeated dose toxicity p.21
SCCS Opinion NOAEL =0.522 µg/cm rat oral 28d reproductive toxicity p.30
SCCS Opinion NOAEL =20 mg/kg/day rat oral 28d reproductive toxicity p.30
SCCS Opinion NOAEL =74 mg/kg/day rat oral 28d reproductive toxicity p.30
SCCS Opinion NOAEL =25 mg/kg/day rat oral 28d reproductive toxicity p.30
SCCS Opinion NOAEL =75 mg/kg/day rat oral 28d reproductive toxicity p.30
SCCS Opinion NOAEL =15 mg/kg/day rat oral 28d reproductive toxicity p.30
SCCS Opinion NOAEL =100 mg/kg bw/day rat dermal - reproductive toxicity p.33
SCCS Opinion NOAEL =150 mg/kg/day rat - - reproductive toxicity p.30
SCCS Opinion NOAEL =1550 - - - - reproductive toxicity p.29
SCCS Opinion NOAEL =1000 mg/ kg bw rat oral 28-day dermal absorption (ref. 8), p.36
SCCS Opinion NOAEL =333 mg/kg bw/d rat oral 28-day dermal absorption (ref. 15), p.37
SCCS Opinion NOAEL =100 mg/kg bw rat oral 28-day dermal absorption (ref. 15), p.37
SCCS Opinion NOAEL =0.0005 mg/kg bw/d - dermal - dermal absorption (ref. 9), p.37
SCCS Opinion NOAEL =20 mg/kg bw/d - dermal - dermal absorption (ref. 9), p.37
SCCS Opinion NOAEL =0.00076 mg/kg bw/d - dermal - dermal absorption (ref. 9), p.37
SCCS Opinion NOAEL =1 % - - - NOAEL study p.38
SCCS Opinion NOAEL =37 - - - - NOAEL study p.37
Regulatory source 32 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 618 mg/kg bw/day - oral 28 day - p.18
Regulatory source - =20 mg/kg/day rat oral 28d - p.30
Regulatory source - =74 mg/kg/day rat dermal 28d - p.30
Regulatory source - =15 mg/kg/day rat - - - p.30
Regulatory source - 1 % - - - - p.38
Regulatory source - 20 mg/kg bw/d - - - - p.37
Regulatory source - 37 - - - - - p.37
Regulatory source dermal absorption 1000 mg/ kg bw rat oral 28-day dermal absorption p.36
Regulatory source dermal absorption =333 mg/kg bw/d rat oral 28-day dermal absorption p.37
Regulatory source dermal absorption 100 mg/kg bw rat oral 28-day dermal absorption p.37
Regulatory source dermal absorption 0.0005 mg/kg bw/d - dermal - dermal absorption p.37
Regulatory source dermal absorption 20 mg/kg bw/d - dermal - dermal absorption p.37
Regulatory source dermal absorption 0.00076 mg/kg bw/d - dermal - dermal absorption p.37
Regulatory source developmental toxicity =25 mg/kg/day rabbit - developmental developmental toxicity p.30
Regulatory source developmental toxicity =75 mg/kg/day rabbit - developmental developmental toxicity p.30
Regulatory source repeated dose toxicity 1000 mg/kg bw/day rat oral Sub-chronic repeated dose toxicity p.17
Regulatory source repeated dose toxicity 400 mg/kg bw/day rat - 28 day repeated dose toxicity p.21
Regulatory source repeated dose toxicity 1000 mg/kg bw/day rat oral 28 day repeated dose toxicity p.32
Regulatory source repeated dose toxicity 1000 mg/kg bw/day rat dermal Sub-chronic repeated dose toxicity p.23
Regulatory source repeated dose toxicity 618 mg/kg bw/day rat oral 28-day repeated dose toxicity p.24
Regulatory source repeated dose toxicity 1000 mg/kg bw/day rat oral 28-day repeated dose toxicity p.24
Regulatory source repeated dose toxicity 400 mg/kg bw/day rat - 28-day repeated dose toxicity p.27
Regulatory source reproductive toxicity 0.522 µg/cm rat oral 28d reproductive toxicity p.30
Regulatory source reproductive toxicity =20 mg/kg/day rat oral 28d reproductive toxicity p.30
Regulatory source reproductive toxicity =74 mg/kg/day rat oral 28d reproductive toxicity p.30
Regulatory source reproductive toxicity =25 mg/kg/day rat oral 28d reproductive toxicity p.30
Regulatory source reproductive toxicity =75 mg/kg/day rat oral 28d reproductive toxicity p.30
Regulatory source reproductive toxicity =15 mg/kg/day rat oral 28d reproductive toxicity p.30
Regulatory source reproductive toxicity 100 mg/kg bw/day rat dermal - reproductive toxicity p.33
Regulatory source reproductive toxicity =150 mg/kg/day rat - - reproductive toxicity p.30
Regulatory source reproductive toxicity 1550 - - - - reproductive toxicity p.29
Regulatory source reproductive toxicity 100 mg/kg bw/day rat - 12 months reproductive toxicity p.41
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier C5INA23HXF UNII - - - chemical -